3-hydroxypropyl vinyl carbonate | 1188536-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-hydroxypropyl vinyl carbonate
• 英文别名: ethenyl 3-hydroxypropyl carbonate
• CAS: 1188536-60-8
• 化学式: C₆H₁₀O₄
• 分子量: 146.143
• InChiKey: CURRMOAEGKSBBH-UHFFFAOYSA-N

物化性质

• 沸点：
  256.2±32.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 3-hydroxypropyl vinyl carbonate 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 以78%的产率得到3-(trimethylsiloxy)propyl vinyl carbonate
  参考文献：
  名称：

  RAPAMYCIN CARBONATE ESTERS

  摘要：

  某些实施例包括通过脂肪酶催化的区域特异性过程合成的罗法昔明在第42位的碳酸酯。这些化合物或其药用可接受的盐在器官和组织移植排斥、自身免疫疾病、增殖性疾病、再狭窄、癌症或微生物感染的治疗中是有用的。

  公开号：

  US20090253733A1
• 作为产物：
  描述：

  氯甲酸乙烯酯 、 1,3-丙二醇 在 盐酸 、 二氯甲烷 、 水 、 magnesium sulfate 、 hexane-diethyl ether 作用下， 以 吡啶 为溶剂， 反应 3.0h， 以to afford 3-hydroxypropyl vinyl carbonate as a colourless liquid (73%, 0.997 g)的产率得到3-hydroxypropyl vinyl carbonate
  参考文献：
  名称：

  RAPAMYCIN CARBONATE ESTERS

  摘要：

  某些实施例包括在42位点上的罗拉霉素碳酸酯，其通过脂肪酶催化的区域特异性过程合成。这些化合物或其药学上可接受的盐在器官和组织移植排斥、自身免疫疾病、增生性疾病、再狭窄、癌症或微生物感染的治疗中是有用的。

  公开号：

  US20090253733A1

文献信息

• SOLUBLE BRANCHED POLYMERS
  申请人：Grigoras Cristian

  公开号：US20140303313A1

  公开（公告）日：2014-10-09

  Branched polymers are prepared from at least (A) at least one monomer having an electron donor moiety, (B) at least one monomer having an electron acceptor moiety, and (C) at least one multifunctional branching agent comprising a urea moiety and at least two N-vinyl groups. The branched polymers are least 20% (by weight) soluble in a solvent for which the corresponding polymer of equal molecular weight made without said multifunctional branching agent is at least 20% (by weight) soluble. Due in part to the wide range of chemistries and solubility and rheological properties, the branched polymers find application in personal care, pharmaceutical/nutritional, and performance chemicals compositions.

  分支聚合物由至少（A）至少一种具有电子给体基团的单体，（B）至少一种具有电子受体基团的单体和（C）至少一种多功能分支剂组成，该分支剂包含尿素基团和至少两个N-乙烯基团。这些分支聚合物在相应的等分子量聚合物不含多功能分支剂的溶剂中至少有20％（重量）的溶解度，由于其广泛的化学性质、溶解度和流变性质，这些分支聚合物在个人护理、制药/营养和性能化学成分中应用广泛。
• US9163102B2
  申请人：——

  公开号：US9163102B2

  公开（公告）日：2015-10-20
• [EN] RAPAMYCIN CARBONATE ESTERS<br/>[FR] ESTERS CARBONATES DE RAPAMYCINE
  申请人：BIOINTERACTIONS LTD

  公开号：WO2009122176A2

  公开（公告）日：2009-10-08

  Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.
• [EN] SOLUBLE BRANCHED POLYMERS<br/>[FR] POLYMÈRES RAMIFIÉS SOLUBLES
  申请人：ISP INVESTMENTS INC

  公开号：WO2013082359A1

  公开（公告）日：2013-06-06

  Branched polymers are prepared from at least (A) at least one monomer having an electron donor moiety, (B) at least one monomer having an electron acceptor moiety, and (C) at least one multifunctional branching agent comprising a urea moiety and at least two N-vinyl groups. The branched polymers are least 20% (by weight) soluble in a solvent for which the corresponding polymer of equal molecular weight made without said multifunctional branching agent is at least 20% (by weight) soluble. Due in part to the wide range of chemistries and solubility and rheological properties, the branched polymers find application in personal care, pharmaceutical/nutritional, and performance chemicals compositions.
• RAPAMYCIN CARBONATE ESTERS
  申请人：Rhodes Alan

  公开号：US20090253733A1

  公开（公告）日：2009-10-08

  Certain embodiments include carbonate esters of rapamycin at position 42 that are synthesized by a lipase catalyzed regio-specific process. These compounds or a pharmaceutically acceptable salt thereof are useful in the treatment of organ and tissue transplant rejection, autoimmune disease, proliferative disorder, restenosis, cancer, or microbial infection.

  某些实施例包括通过脂肪酶催化的区域特异性过程合成的罗法昔明在第42位的碳酸酯。这些化合物或其药用可接受的盐在器官和组织移植排斥、自身免疫疾病、增殖性疾病、再狭窄、癌症或微生物感染的治疗中是有用的。