(S)-(+)-2-(2-Pyridinecarboxamido)-2'-(diphenylphosphanyl)-1,1'-binaphthyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(+)-2-(2-Pyridinecarboxamido)-2'-(diphenylphosphanyl)-1,1'-binaphthyl
• 英文别名: N-[1-(2-diphenylphosphanylnaphthalen-1-yl)naphthalen-2-yl]pyridine-2-carboximidic acid
• 化学式: C₃₈H₂₇N₂OP
• 分子量: 558.619
• InChiKey: MDDPOIZYGYDMSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-吡啶甲酸 、 (R)‐2′‐(diphenylphosphaneyl)‐[1,1′‐binaphthalen]‐2‐amine 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到(S)-(+)-2-(2-Pyridinecarboxamido)-2'-(diphenylphosphanyl)-1,1'-binaphthyl
  参考文献：
  名称：

  Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones

  摘要：

  High enantioselectivity (up to 98 % ee) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing Cu(I) complexes of the novel chiral P,N ligands 1. The high enantioselectivities are best achieved using [Cu(OTf)](2) small middle dotC(6)H(6) as the copper catalyst precursor in nonpolar solvents such as toluene or Cl(CH(2))(2)Cl. R=H, CH(3); Tf=F(3)CSO(2).

  DOI：

  10.1002/(sici)1521-3773(19991203)38:23<3518::aid-anie3518>3.0.co;2-p

文献信息

• US6380392B1
  申请人：——

  公开号：US6380392B1

  公开（公告）日：2002-04-30
• Development of New Chiral P,N Ligands and Their Application in the Cu-Catalyzed Enantioselective Conjugate Addition of Diethylzinc to Enones
  作者：Xinquan Hu、Huilin Chen、Xumu Zhang

  DOI：10.1002/(sici)1521-3773(19991203)38:23<3518::aid-anie3518>3.0.co;2-p

  日期：——

  High enantioselectivity (up to 98 % ee) has been achieved for the conjugate addition of diethylzinc to acyclic enones utilizing Cu(I) complexes of the novel chiral P,N ligands 1. The high enantioselectivities are best achieved using [Cu(OTf)](2) small middle dotC(6)H(6) as the copper catalyst precursor in nonpolar solvents such as toluene or Cl(CH(2))(2)Cl. R=H, CH(3); Tf=F(3)CSO(2).