N-叔-丁基-N-乙基异丁基胺 | 244191-68-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-叔-丁基-N-乙基异丁基胺
• 中文别名: N-叔丁基-N-乙基异丁基胺
• 英文名称: tert-butylisobutylethylamine
• 英文别名: N-tbutyl-N-ethyl-N-i-butyl amine；tert-butyl-N-ethyl-N-isobutylamine；N-tert-butyl-N-ethyl-2-methylpropan-1-amine
• CAS: 244191-68-2
• 化学式: C₁₀H₂₃N
• mdl: MFCD00274228
• 分子量: 157.299
• InChiKey: PRLPOYQXHQUODC-UHFFFAOYSA-N

物化性质

• 沸点：
  157 °C(lit.)
• 密度：
  0.772 g/mL at 25 °C(lit.)
• 闪点：
  97 °F

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S16,S26,S36
• 危险类别码：
  R10,R36/37/38
• 危险品运输编号：
  UN 1993 3/PG 3

反应信息

• 作为产物：
  描述：

  硫酸二乙酯 、 isobutyl(tert-butyl)amine 以72%的产率得到N-叔-丁基-N-乙基异丁基胺
  参考文献：
  名称：

  Molecular Addition Compounds. 15. Synthesis, Hydroboration, and Reduction Studies of New, Highly Reactive tert-Butyldialkylamine−Borane Adducts

  摘要：

  Two series of tert-butyldialkylamines have been prepared and examined for borane complexation. The complexing ability of each amine in the two series examined decreases in the order shown. First series: t-BuN(CH2CH2)(2)O 1a > t-BuNEt2 Ib > t-BuNPr(2)(n)1c > t-BuN(CH2CH2OMe)(2) Id much greater than t-BuNBu2i le. Second series: t-(BuNBuMe)-Me-i 2a > t-(BuNPrMe)-Me-i 2b > t-(BuNBuEt)-Et-i 2c > t-(BuNBuPrn)-Pr-i 2d much greater than t-(BuNPrEt)-Et-i 2e. The reactivity of the corresponding borane adducts toward 1-octene increases in the reverse order. The following amines form highly reactive liquid borane adducts hydroborating 1-octene in tetrahydrofuran at room temperature in less than 1 h: t-BuN(CH2CH2OMe)(2), t-(BuNBuEt)-Et-i, and t-(BuNPrMe)-Me-i. The limit of borane complexation among the amines examined is reached for t-BuNBu2i exchanging borane neither with EMS nor with BH3-THF. Among the various borane adducts prepared, the more promising borane adducts, t-Bu(CH3OCH2CH2)(2)N-BH3 (7), t-(BuMePrN)-N-i-BH3 (8), and t-(BuEtBuN)-N-i-BH3 (9), were selected for complete hydroboration and reduction studies. Hydroboration studies with the new, highly reactive trialkylamine-borane adducts 7-9 and representative olefins, such as l-hexene, styrene, beta-pinene, cyclopentene, norbornene, cyclohexene, 2-methyl-2-butene, alpha-pinene, and 2,3-dimethyl-2-butene, in tetrahydrofuran, dioxane, tert-butyl methyl ether, n-pentane, and dichloromethane, at room temperature (22 +/- 3 degrees C) were carried out. The reactions are faster in dioxane, requiring 1-2 h for the hydroboration of simple, unhindered olefins to the trialkylborane stage. Moderately hindered olefins, such as cyclohexene and 2-methyl-2-butene, give the corresponding dialkylboranes rapidly, with further slow hydroboration. However, the more hindered olefins, alpha-pinene and 2,3-dimethyl-2-butene, give stable monoalkylboranes very rapidly, with further hydroboration proceeding relatively slowly. The hydroborations can also be carried out conveniently in other solvents, such as THF, tert-butyl methyl ether, and n-pentane. A significant; rate retardation is observed in dichloromethane. Regioselectivity studies of l-hexene and styrene using these amine-borane adducts show selectivities similar to that of BH3-THF. The rates and stoichiometry of the reaction of t-BuMePriN-BH3 in tetrahydrofuran with selected organic compounds containing representative functional groups were also examined at room temperature. The reductions of esters, amides, and nitriles, which exhibit a sluggish reaction at room temperature, proceed readily under reflux conditions in tetrahydrofuran and dioxane and without solvent (at 85-90 degrees C). The carrier amines can be recovered by simple acid-base manipulations in good yield and readily recycled to make the borane adducts.

  DOI：

  10.1021/jo990379b
• 作为试剂：
  描述：

  DL-正亮氨酸 在 吗啉 、 C₁₀₈H₈₈Cl₄Fe₂N₈O₈Pd₄S₄ 、 silver trifluoromethanesulfonate 、 manganese(II) acetate 、 sodium hydroxide 、 N-叔-丁基-N-乙基异丁基胺 作用下， 以 正己烷 、 二氯甲烷 、 水 、 溶剂黄146 为溶剂， 反应 31.5h， 生成 (3S,4R)-3-benzamido-4-butyl-2,5-dioxo-3-phenylpyrrolidin-1-yl methanesulfonate
  参考文献：
  名称：

  不对称钯（II）催化级联反应，通过1,4加成和Nef型反应生成季氨基琥珀酰亚胺

  摘要：

  简单的起始原料，高价值的产品：一种基于二核二茂铁的Pd II复合物，将外消旋的N-苯甲酰基α-氨基酸，硝基烯烃，乙酸酐和乙酸锰的混合物转变成生物学上有意义的季氨基琥珀酰亚胺。产物以对映体富集的形式作为单一非对映体获得。级联机理的关键步骤是在硝基烯烃中原位生成的内酯1,4加成和Nef型反应。

  DOI：

  10.1002/anie.201307334

文献信息

• BENZODICYCLOALKANE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
  申请人：SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

  公开号：US20190161468A1

  公开（公告）日：2019-05-30

  It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.

  本文提供了一种苯并螺环烷衍生物，以及其制备方法和用途。具体而言，本文提供了一种式（I）化合物，或其药用可接受的盐、立体异构体或溶剂化合物，以及其制备方法，并用于制备治疗疼痛药物的用途。
• Borane-trialkylamine hydroboration agents
  申请人：Sigma-Aldrich Co.

  公开号：US06248885B1

  公开（公告）日：2001-06-19

  Borane-trialkylamines of the formula H3B.NRR1R2 wherein R is a tertiary alkyl group having 4 to 8 carbon atoms, and R1 and R2 are the same or different straight or branched chain alkyl from 1 to 4 carbon atoms are provided. The compounds are new hydroboration agents.

  化合物的名称是H3B.NRR1R2，其中R是4到8个碳原子的三级烷基，R1和R2是1到4个碳原子的相同或不同的直链或支链烷基。这些化合物是新的氢化硼试剂。
• Oxadiazole Derivatives
  申请人：Quattropani Anna

  公开号：US20100240658A1

  公开（公告）日：2010-09-23

  The invention relates to compounds of formula I: wherein R 1 , R 2 , R a , R b , W, Q and S have the meanings given in claim 16 . The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.

  本发明涉及式I的化合物：其中R1、R2、Ra、Rb、W、Q和S的含义如权利要求16所述。该化合物可用于治疗自身免疫性疾病，如多发性硬化症。
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20130195920A1

  公开（公告）日：2013-08-01

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种带有一个或多个可生物降解基团的阳离子脂质，该基团位于脂质部分（如疏水链）内。这些阳离子脂质可以被纳入脂质粒中，以传递活性物质，例如核酸。本发明还涉及包括中性脂质、能够减少聚集的脂质、本发明中的阳离子脂质以及可选的甾醇的脂质粒。该脂质粒还可以进一步包括治疗剂，例如核酸。
• Benzobicycloalkane derivatives, their preparation and pharmaceutical use thereof
  申请人：SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.

  公开号：US10577346B2

  公开（公告）日：2020-03-03

  It is provided herein a benzobicycloalkane derivative, and a preparation method and use thereof. In particular, it is provided herein a compound of Formula (I), or a pharmaceutically acceptable salt, stereoisomer or solvate thereof, a preparation method, and a use thereof in preparation of drugs for treating pain.

  本文提供了一种苯并双环烷烃衍生物及其制备方法和用途。特别是提供了一种式（I）化合物或其药学上可接受的盐、立体异构体或溶解物、制备方法及其在制备治疗疼痛药物中的用途。