N¹-trityl-N²-(2-(tritylamino)ethyl)ethane-1,2-diamine | 145901-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: N¹-trityl-N²-(2-(tritylamino)ethyl)ethane-1,2-diamine
• 英文别名: N'-trityl-N-[2-(tritylamino)ethyl]ethane-1,2-diamine
• CAS: 145901-58-2
• 化学式: C₄₂H₄₁N₃
• 分子量: 587.808
• InChiKey: PGUOQEGLSOJYRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  36.1
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N¹-trityl-N²-(2-(tritylamino)ethyl)ethane-1,2-diamine 在 lithium aluminium tetrahydride 、 三乙胺 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 73.0h， 生成 N,N,N',N'-Tetrakis-[2-(trityl-amino)-ethyl]-butane-1,4-diamine
  参考文献：
  名称：

  Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group

  摘要：

  The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5(a-f)) were obtained by removing the trityl groups with 5.0 M HCl solution. Alternatively, the hexamine ligands could be also prepared via amidation and reduction reactions. The synthetic routes described here are mild, efficient and easy to handle.

  DOI：

  10.1080/00397919708004172
• 作为产物：
  描述：

  三苯基氯甲烷 、 二乙烯三胺 在 二乙胺 作用下， 以 异丙醇 为溶剂， 反应 21.0h， 以95%的产率得到N¹-trityl-N²-(2-(tritylamino)ethyl)ethane-1,2-diamine
  参考文献：
  名称：

  在氟载体上快速寡糖合成

  摘要：

  新型氟载体Hfb（六氟链型丁酰基）易于制备。的HFB组容易引入到异头羟基的碳水化合物的，并且是切割后可回收再利用。Hfb基团的使用适用于快速寡糖合成，其中合成中间体可以使用氟和普通有机溶剂进行纯化。每种合成中间体都可以通过TLC，NMR和质谱监测。

  DOI：

  10.1016/j.tet.2004.07.027

文献信息

• [EN] TARGETED RADIOPHARMACEUTICALS FOR THE DIAGNOSIS AND TREATMENT OF PROSTATE CANCER<br/>[FR] PRODUITS RADIOPHARMACEUTIQUES CIBLÉS POUR LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER DE LA PROSTATE
  申请人：BAYER AS

  公开号：WO2021013978A1

  公开（公告）日：2021-01-28

  A compound of general formula (I): wherein: n is 1, 2 or 3; R1, R2, R3 and R4, independently represent OH or Q; and 20 Q represents a tissue-targeting moeity selected from the group consisting of or a stereoisomer, a hydrate, a solvate, or a salt thereof, or a mixture of same, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said 25 compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of soft tissue diseases, as a sole agent or in combination with other active ingredients.

  通用式(I)的化合物：其中：n为1、2或3；R1、R2、R3和R4独立地代表OH或Q；Q代表从群组中选择的组织靶向基团，或其立体异构体、水合物、溶剂合物、盐或其混合物，制备所述化合物的方法，用于制备所述化合物的中间化合物，包含所述化合物的药物组合物和组合物，以及用于制造用于治疗或预防疾病的药物组合物的所述化合物的用途，特别是软组织疾病的治疗或预防，作为唯一药剂或与其他活性成分结合使用。
• Complexes and Ligands
  申请人：The General Hospital Corporation

  公开号：US20220025254A1

  公开（公告）日：2022-01-27

  The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.

  本申请提供了配体和包括这些配体的荧光或发光配合物。
• Oligosaccharide Synthesis on a Fluorous Support
  作者：Tsuyoshi Miura、Kohtaro Goto、Daisuke Hosaka、Toshiyuki Inazu

  DOI：10.1002/anie.200250531

  日期：2003.5.9
• Rapid oligosaccharide synthesis on a fluorous support
  作者：Kohtaro Goto、Tsuyoshi Miura、Daisuke Hosaka、Hiroharu Matsumoto、Mamoru Mizuno、Hide-ki Ishida、Toshiyuki Inazu

  DOI：10.1016/j.tet.2004.07.027

  日期：2004.9

  The novel fluorous support Hfb (hexakisfluorous chain-type butanoyl) was easily prepared. The Hfb group was readily introduced into the anomeric hydroxyl group of a carbohydrate, and was recyclable after cleavage. The use of the Hfb group was applicable for the rapid oligosaccharide synthesis in which the synthetic intermediates could be purified using fluorous and normal organic solvents. Each synthetic

  新型氟载体Hfb（六氟链型丁酰基）易于制备。的HFB组容易引入到异头羟基的碳水化合物的，并且是切割后可回收再利用。Hfb基团的使用适用于快速寡糖合成，其中合成中间体可以使用氟和普通有机溶剂进行纯化。每种合成中间体都可以通过TLC，NMR和质谱监测。
• Synthesis of Hexamine Ligands by Using Trityl as an N-Blocking Group
  作者：Erle Zang、Peter J. Sadler

  DOI：10.1080/00397919708004172

  日期：1997.9

  The amino-groups of diethylenetriamine were regioselectively protected by trityl groups and then reacted with dihalogenated alkylane to give the terminal N-blocked hexamine derivatives, from which a series of hexamine ligands (5(a-f)) were obtained by removing the trityl groups with 5.0 M HCl solution. Alternatively, the hexamine ligands could be also prepared via amidation and reduction reactions. The synthetic routes described here are mild, efficient and easy to handle.