o-hydroxyphenyl isocyanate | 63905-47-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: o-hydroxyphenyl isocyanate
• 英文别名: 2-Isocyanatophenol
• CAS: 63905-47-5
• 化学式: C₇H₅NO₂
• 分子量: 135.122
• InChiKey: OTRGSHJAEDLEFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  o-hydroxyphenyl isocyanate 在 sodium hydroxide 作用下， 以 吡啶 为溶剂， 生成 2-[4-[(2-Hydroxyphenyl)carbamoylamino]phenoxy]-2-methylpropanoic acid
  参考文献：
  名称：

  2- [4-[[[（（芳基氨基）羰基]氨基]苯氧基] -2-甲基丙酸对血红蛋白对氧的亲和力的合成和影响研究：结构-活性关系。

  摘要：

  合成了一系列2- [4-[[[[（（取代-苯基）氨基]羰基]氨基]苯氧基] -2-甲基丙酸和其他取代的苯氧基乙酸，并测试了它们降低血红蛋白对氧的亲和力的能力。发现2- [4-[[[（（3,4,5-三氯苯基）氨基]羰基]氨基]苯氧基] -2-甲基丙酸是已知的最有效的化合物。讨论了合成化合物的构效关系。

  DOI：

  10.1021/jm00130a021
• 作为产物：
  描述：

  水杨基羟肟酸 以 various solvent(s) 为溶剂， 生成 o-hydroxyphenyl isocyanate
  参考文献：
  名称：

  Matrix-isolation and computational study of salicylhydroxamic acid and its photochemical degradation

  摘要：

  在12–21 K的氩气基质中记录了水杨酸羟肟酸（sha）的红外吸收光谱。对sha所有可能的反式和顺式酮构象进行了B3LYP/6-311++G(d,p)水平的理论计算。计算得出的能量、优化后的结构及相对丰度显示，sha在基质中以z,z,z,z-构象存在（相对于C–O(–H)、C–C(–N)、C–N和N–O键），并且通过两个分子内氢键得以稳定。通过可见光和紫外光照射，获得了在基质和甲醇-水溶液中化合物的光解碎裂产物。在氩气基质中，主要光解产物为邻羟基苯异氰酸酯，而在甲醇-水溶液中，主要光解产物为水杨胺。

  DOI：

  10.1039/b418033j

文献信息

• Peripheral vasodilating agent containing piperidine derivative as active
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05656642A1

  公开（公告）日：1997-08-12

  The present invention relates to novel peripheral vasodilating agents characterized by each containing as an active ingredient, a piperidine derivative or pharmaceutically acceptable salt thereof having excellent peripheral vasodilating activity. Said piperidine derivative or pharmaceutically acceptable salt thereof is represented by the general formula (1): ##STR1## (wherein R, R.sup.1 and R.sup.2 are the same as defined above.

  本发明涉及一种新型外周扩血管药物，其特征在于每种药物均包含作为活性成分的哌啶衍生物或其具有优异外周扩血管活性的药用盐。所述的哌啶衍生物或其药用盐由通式（1）表示：##STR1##（其中R、R.sup.1和R.sup.2与上文中定义的相同）。
• Compositions for repelling crawling insects
  申请人：——

  公开号：US20020094993A1

  公开（公告）日：2002-07-18

  The present invention relates to novel compositions, comprising a repellent and an additive, where the additive is selected from the group consisting of phenol, benzaldehyde, benzoic acid or derivatives thereof and is present in a ratio of from 10:100 to 200:100% by weight to the repellent, and to their use for repelling crawling harmful insects, in particular ants or cockroaches.

  本发明涉及新型组合物，包括一种驱虫剂和一种添加剂，其中所述添加剂选自苯酚、苯甲醛、苯甲酸或其衍生物组成的群体，并以10:100至200:100％重量的比例存在于驱虫剂中，以及其用于驱赶爬行有害昆虫，特别是蚂蚁或蟑螂。
• Method for immunological analysis of trace components
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0015518A1

  公开（公告）日：1980-09-17

  In a method for the immunological analysis of trace components by marking or labelling an antigen or antibody with a marker, an immune reaction is caused using an antigen or antibody marked with a fogging agent for silver halide, the labelled antigen or antibody is separated from the labelled antigen-antibody reaction product, the silver halide is developed in the presence of either one of the labelled antigen or antibody and the labelled antigen-antibody reaction product, and the density obtained is measured. The method is comparable to radioimmunoassay in having high reproductibility and sufficient sensitivity but does not involve any risk due to radiation.

  在一种用标记物标记或标示抗原或抗体从而对痕量成分进行免疫分析的方法中，使用卤化银雾剂标记的抗原或抗体引起免疫反应，将标记的抗原或抗体与标记的抗原-抗体反应产物分离，在标记的抗原或抗体和标记的抗原-抗体反应产物中任选一种存在的情况下显影卤化银，并测量所获得的密度。 该方法与放射免疫分析法相似，具有较高的重现性和足够的灵敏度，但不涉及任何辐射风险。
• Method for immunochemical measurement
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0047470A1

  公开（公告）日：1982-03-17

  A method for immunochemical assay of an antigen or antibody by labelling the antigen or antibody with a specific cyanine or merocyanine dye containing a carboxy group followed by effecting an immune reaction and photochemical processing thereof is provided. The amount of the antigen or antibody is measured in term of optical density of developed silver halide which is brought into contact with either the antigen-antibody reaction product or the unreacted material. This immunochemial assay method gives high detection sensitivity in a simple operation manner.

  本发明提供了一种对抗原或抗体进行免疫化学检测的方法，即用含有羧基的特异性青色或梅洛青染料标记抗原或抗体，然后对其进行免疫反应和光化学处理。 抗原或抗体的量是通过与抗原-抗体反应产物或未反应物质接触的显影卤化银的光密度来测量的。 这种免疫化学检测方法操作简单，检测灵敏度高。
• Analysis element for immunochemical measurement of trace components and for enzyme assay and methods using the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0047471A1

  公开（公告）日：1982-03-17

  In a method of assay for a trace component such as antigen, antibody or enzyme utilizing immunochemical reaction or enzyme reaction in combination with photographic detection system comprising measuring optical density of a silver image formed in proportion to the antigen, antibody or enzyme to be measured, a novel analysis sheet comprising a support having provided thereon, in succession, a water absorbing layer and a silver halide emulsion layer is employed. The analysis sheet essentially increases the amount of water absorbed so that the analysis sheet is extremely effective for improving detection sensitivity.

  在一种利用免疫化学反应或酶反应结合照相检测系统（包括测量与待测抗原、抗体或酶成比例的银图像的光密度）检测微量成分（如抗原、抗体或酶）的方法中，采用了一种新型分析片，该分析片由一个支撑物组成，支撑物上依次设有吸水层和卤化银乳剂层。该分析片从根本上增加了吸水量，因此能非常有效地提高检测灵敏度。