2,2-二甲基-4-苯基-3,4-二氢色烯-7-醇 | 59257-81-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 中文名称: 2,2-二甲基-4-苯基-3,4-二氢色烯-7-醇
• 英文名称: 7-hydroxy-2,2-dimethyl-4-phenylchroman
• 英文别名: 2,2-dimethyl-4-phenyl-chroman-7-ol；2,2-dimethyl-7-hydroxy-4-phenylchroman；2,2-dimethyl-4-phenyl-3,4-dihydrochromen-7-ol
• CAS: 59257-81-7
• 化学式: C₁₇H₁₈O₂
• 分子量: 254.329
• InChiKey: STFVJAGVPMVNJE-UHFFFAOYSA-N

物化性质

• 沸点：
  138-140 °C(Press: 0.003-0.006 Torr)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-二甲基-4-苯基-3,4-二氢色烯-7-醇 、 环氧氯丙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以95%的产率得到7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman
  参考文献：
  名称：

  7-Aminopropoxy chromane and chromenes

  摘要：

  化合物的公式（I）：其中R.sub.1为氢、1至4个碳原子的烷基或苄基；R.sub.2为氢或1至4个碳原子的烷基，或与R.sub.1结合以使NR.sub.1 R.sub.2基团成为5、6或7成员饱和杂环环；R.sub.3为氢、1至4个碳原子的烷基或1至4个碳原子的酰基；R.sub.4为芳香族基；R.sub.5为氢或1至4个碳原子的烷基，R.sub.6为氢或1至4个碳原子的烷基；X为--CH.sub.2--或氧原子，虚线表示单键或双键，对诱导厌食和情绪调节效果有用。

  公开号：

  US04093631A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢溴酸 、 溶剂黄146 作用下， 生成 2,2-二甲基-4-苯基-3,4-二氢色烯-7-醇
  参考文献：
  名称：

  Clayton et al., Journal of the Chemical Society, 1953, p. 581,584

  摘要：

  DOI：

文献信息

• Anorexic chromans
  申请人：Beecham Group Limited

  公开号：US04080335A1

  公开（公告）日：1978-03-21

  Compounds within formula ##STR1## and their salts wherein X is alkylene of 2 - 4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1 - 6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1 - 6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1 - 4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1 - 4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.

  在化学式##STR1##中的化合物及其盐，其中X是2-4个碳原子的烷基；R.sub.1是氢或1-6个碳原子的烷基；R.sub.2是氢，1-6个碳原子的烷基或苄基，或者R.sub.1和R.sub.2与它们连接的氮原子一起形成一个5、6或7元饱和环；R.sub.3是芳基；R.sub.4是氢或1-4个碳原子的烷基；R.sub.5是氢或1-4个碳原子的烷基；已发现具有改变情绪和诱导厌食的活性。
• Chromans to treat depression and reduce appetite
  申请人：Beecham Group Limited

  公开号：US04148909A1

  公开（公告）日：1979-04-10

  Compounds within formula ##STR1## and their salts wherein X is alkylene of 2-4 carbon atoms; R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms; R.sub.2 is hydrogen, alkyl of 1-6 carbon atoms or benzyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5-, 6- or 7-membered saturated ring; R.sub.3 is aryl; R.sub.4 is hydrogen or alkyl of 1-4 carbon atoms; and R.sub.5 is hydrogen or alkyl of 1-4 carbon atoms; have been found to possess mood-modifying and anorexia inducing activity.

  在式子##STR1##内和它们的盐中，其中X是2-4个碳原子的烷基；R.sub.1是氢或1-6个碳原子的烷基；R.sub.2是氢、1-6个碳原子的烷基或苄基，或者R.sub.1和R.sub.2与它们连接的氮原子一起形成一个5、6或7元饱和环；R.sub.3是芳基；R.sub.4是氢或1-4个碳原子的烷基；R.sub.5是氢或1-4个碳原子的烷基。已发现这些化合物具有调节情绪和引起厌食的活性。
• Heterocyclic containing chromans
  申请人：Beecham Group Limited

  公开号：US04234726A1

  公开（公告）日：1980-11-18

  Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof wherein the NR.sub.1 R.sub.2 moiety is a 5-, 6-, or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is naphthyl or phenyl unsubstituted or substituted by one or two substituents selected from the group consisting of fluorine, chlorine, bromine, methoxyl, benzyloxyl, trifluoromethyl, methyl, cyano, nitro, acetoxyl, amino, methylamino, ethylamino, dimethylamino, diethylamino, acetamide, hydroxyl, methoxycarbonyl, ethoxycarbonyl, carboxamido, sulphonamido, carboxy, trifluoromethylthio, trifluoromethoxyl, methylsulphonyl, trifluomethylsulphonyl and methylthio; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms; R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is oxygen and the dotted line represents a single or double bond.

  化合物的公式（I）：##STR1## 或其药学上可接受的盐，其中NR.sub.1 R.sub.2基团是5、6或7成员饱和杂环环；R.sub.3是氢、1至4个碳原子的烷基或1至4个碳原子的酰基；R.sub.4是萘基或苯基，未取代或取代一个或两个取代基，所述取代基选自氟、氯、溴、甲氧基、苄氧基、三氟甲基、甲基、氰基、硝基、乙酰氧基、氨基、甲氨基、乙氨基、二甲基氨基、二乙基氨基、乙酰胺、羟基、甲氧羰基、乙氧羰基、羧酰胺、磺酰胺、羧基、三氟甲硫基、三氟甲氧基、甲基磺酰基、三氟甲基磺酰基和甲硫基；R.sub.5是氢或1至4个碳原子的烷基；R.sub.6是氢或1至4个碳原子的烷基；X是氧，点线表示单键或双键。
• Anemone plant named ‘Curtain Call Pink’
  申请人：Hansen Hans A

  公开号：USPP030739P2

  公开（公告）日：2019-07-23

  The new and distinct cultivar of ornamental Japanese Anemone plant named Anemone ‘Curtain Call Pink’ with compact spreading habit, vertical peduncle of numerous semi-double flowers with bright rose pink petals, beginning late summer and continuing into early fall, set just above the dark green, tri-foliate leaves with irregularly serrated to bi-serrated. The new plant is useful for landscaping as a specimen, en masse, or in containers.

  这是一种新的、独特的观赏日本银莲花植物品种，名为“Anemone‘Curtain Call Pink’”。它具有紧凑的扩散习性，垂直的花茎上有众多的半重瓣花朵，花瓣呈鲜艳的玫瑰粉色，开花时间从夏末延续到初秋，花朵位于深绿色的三出叶片上，叶缘呈不规则锯齿状或双锯齿状。这种新植物可用于景观设计中的单株、群植或容器中。
• Polycyclic chromenes useful as antidepressants and anorexics
  申请人：Beecham Group Limited

  公开号：US04133883A1

  公开（公告）日：1979-01-09

  Compounds of the formula (I): ##STR1## and salts thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R.sub.1 so that the NR.sub.1 R.sub.2 moiety is a 5 -, 6- or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is an aromatic group; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is --CH.sub.2 -- or an oxygen atom and the dotted line represents a single or double bond, are useful for inducing anorexia and for their mood-modifying effects.

  式(I)的化合物和其盐，其中R1是氢、1至4个碳原子的烷基或苄基；R2是氢、1至4个碳原子的烷基或与R1连接形成NR1R2基团为5、6或7元饱和杂环环；R3是氢、1至4个碳原子的烷基或1至4个碳原子的酰基；R4是芳香基；R5是氢或1至4个碳原子的烷基；R6是氢或1至4个碳原子的烷基；X是--CH2--或氧原子，虚线表示单键或双键。这些化合物有助于诱导厌食症，并具有调节情绪的作用。