(5-Methyl-2-oxo-1,3-dioxan-5-yl)methyl prop-2-enoate | 25760-52-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: (5-Methyl-2-oxo-1,3-dioxan-5-yl)methyl prop-2-enoate
• CAS: 25760-52-5
• 化学式: C₉H₁₂O₅
• 分子量: 200.191
• InChiKey: JUTGEUMRGWKVPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 在 盐酸 、 水 、 对甲苯磺酸 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 (5-Methyl-2-oxo-1,3-dioxan-5-yl)methyl prop-2-enoate
  参考文献：
  名称：

  通过开环聚合和通过迈克尔型加成反应进行的后聚合改性相结合，全面合成功能性可生物降解聚合物

  摘要：

  通过结合开环聚合（ROP）和Michael型共轭加成反应，可以轻松地基于新型环状碳酸酯单体，碳酸丙烯酰酯（AC）和甲基丙烯酸丙烯酰酯（MAC）制备各种功能性可生物降解的聚合物。从1,1,1-三（羟甲基）乙烷通过四个简单的步骤合成了AC和MAC单体，总收率良好（约40％）。AC和MAC能够与ε-己内酯（ε-CL）和d，l共聚辛酸亚锡为催化剂，在110°C的甲苯中混合乙交酯（LA），得到具有可控制的（甲基）丙烯酰基官能团和分子量的可生物降解的共聚物。丙烯酰基适合于在温和条件下，通过不同的含硫醇分子（例如2-巯基乙醇，3-巯基丙酸，半胱胺，半胱氨酸和精氨酸-甘氨酸-天冬氨酸-半胱氨酸（RGDC）肽）与Michael型共轭物加成，提供具有极大不同功能性（例如，羟基，羧基，胺，氨基酸和肽）和特性（例如，亲水性，细胞粘附）的可生物降解材料。值得注意的是，使用2-巯基乙醇，半胱胺和半胱氨酸可实现100％

  DOI：

  10.1021/ma901897y

文献信息

• [EN] A METHOD OF MAKING A POLYMER PREFERABLY AN (ALKYL)ACRYLOYL POLYCARBONATE, THE POLYMER AND (ALKYL)ACRYLOYL POLYCARBONATE OBTAINED, AND A BIODEVICE COMPRISING SAME<br/>[FR] PROCÉDÉ DE FABRICATION D'UN POLYMÈRE DE PRÉFÉRENCE D'UN POLYCARBONATE D'(ALKYL)ACRYLOYLE, POLYMÈRE ET POLYCARBONATE D'(ALKYL)ACRYLOYLE OBTENUS ET BIODISPOSITIF LES COMPRENANT
  申请人：SSENS B V

  公开号：WO2011009478A1

  公开（公告）日：2011-01-27

  The invention relates to a method for making a polymer wherein during the polymerisation is incorporated in the polymer chain by ring opening polymerisation a cyclic (alkyl)acryloyl carbonate having the formula (4): wherein R1 and R2 each independently are hydrogen, methyl or ethyl. Preferrable the polymer is an (alkyl)acryloyl polycarbonate such that at least one first monomer a cyclic (alkyl)acryloyl carbonate having the formula (4). The (alkyl)acryloyl polyester may be modified and used in biodevices.

  这项发明涉及一种制备聚合物的方法，其中在聚合过程中通过环氧聚合将具有化学式（4）的环状（烷基）丙烯酰基碳酸酯并入聚合物链中，其中R1和R2各自独立地为氢、甲基或乙基。最好聚合物是一种（烷基）丙烯酰基聚碳酸酯，以至少一种第一单体为具有化学式（4）的环状（烷基）丙烯酰基碳酸酯。这种（烷基）丙烯酰基聚酯可以被改性并用于生物器件。
• Electrospun Poly(<scp>l</scp>-lactide-<i>co</i>-acryloyl carbonate) Fiber Scaffolds With a Mechanically Stable Crimp Structure For Ligament Tissue Engineering
  作者：Fei Chen、James W. S. Hayami、Brian G. Amsden

  DOI：10.1021/bm401813j

  日期：2014.5.12

  The aim of this study was to prepare a fibrous scaffold that possesses a crimped morphology using a photo-cross-linkable biodegradable copolymer. To obtain the crimped morphology, the polymer was first electrospun onto a rotating wire mandrel to obtain aligned straight fibers. Postprocessing by immersion in aqueous buffer at 37 degrees C generated a crimplike pattern in the fibers. It was reasoned that cross-linking the fibers following formation of the crimped structure would endow the scaffolds with a recoverable crimp pattern and mechanical properties similar to that of the collagen fibers in the anterior cruciate ligament (ACL). To achieve this aim, a trimethylene carbonate based monomer bearing an acrylate pendant group was synthesized and copolymerized with L-lactide. The copolymer was electrospun and photo-cross-linked yielding fibrous scaffolds possessing a substantial increase in tensile modulus and crimp stability compared to the uncross-linked fibrous scaffolds. The crimp-stabilized scaffolds also showed good cytocompatibility toward 3T3 fibroblasts, which attached and grew along the crimped fibers. These findings suggest that these cross-linked fiber scaffolds may be useful for the generation of cultured ligament tissue.
• METHOD OF MAKING A POLYMER PREFERABLY AN (ALKYL) ACRYLOYL POLYCARBONATE, THE POLYMER AND (ALKYL) ACRYLOYL POLYCARBONATE OBTAINED, AND A BIODEVICE COMPRISING SAME
  申请人：Chen Wei

  公开号：US20120294845A1

  公开（公告）日：2012-11-22

  The invention relates to a method for making a polymer wherein during the polymerisation is incorporated in the polymer chain by ring opening polymerisation a cyclic (alkyl)acryloyl carbonate having the formula (4): wherein R 1 and R 2 each independently are hydrogen, methyl or ethyl. Preferable the polymer is an (alkyl)acryloyl polycarbonate such that at least one first monomer a cyclic (alkyl)acryloyl carbonate having the formula (4). The (alkyl)acryloyl polyester may be modified and used in biodevices.
• METHOD FOR MAKING A POLYMER, A POLYMER ARTICLE, A BIODEVICE, AND CYCLIC CARBONATE
  申请人：Zhong Zhiyuan

  公开号：US20140249268A1

  公开（公告）日：2014-09-04

  The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L=—[CH2]n with n=0-10, or L=−[CH2]p-S—S—[CH2]q with p and q are 0-5 or L=-[PEG]- with PEG is a group that comprises a —[CH2CH2O]m-group with m=1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer A may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates.
• US8927196B2
  申请人：——

  公开号：US8927196B2

  公开（公告）日：2015-01-06