N-allyl-2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethyl-propyl)aminoxy]propionamide | 763105-81-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: N-allyl-2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethyl-propyl)aminoxy]propionamide
• 英文别名: 2-[tert-butyl-(1-diethoxyphosphoryl-2,2-dimethylpropyl)amino]oxy-N-prop-2-enylpropanamide
• CAS: 763105-81-3
• 化学式: C₁₉H₃₉N₂O₅P
• 分子量: 406.503
• InChiKey: ZENMJTYDILHIFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-allyl-2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethyl-propyl)aminoxy]propionamide 以 叔丁醇 为溶剂， 反应 12.0h， 以70%的产率得到4-[[Tert-butyl-(1-diethoxyphosphoryl-2,2-dimethylpropyl)amino]oxymethyl]-3-methylpyrrolidin-2-one
  参考文献：
  名称：

  SG1 based alkoxyamines as radical initiators for the synthesis of lactones and lactames

  摘要：

  Recently, it has been shown that alkoxyamines can be used as radical initiators in tin-free radical chemistry. Thus, it prompted us to develop the preparation of highly valuable alkoxyamines via ionic chemistry and the radical cyclization was triggered by thermal initiation. Following that procedure, bicyclic, spiro and eight-membered lactones were easily prepared in good yields with very high stereoselectivity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.100
• 作为产物：
  描述：

  2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethylpropyl)aminoxy]propionic acid 在 4-二甲氨基吡啶 、 氯化亚砜 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 16.75h， 生成 N-allyl-2-[N-tert-butyl-N-(1-diethoxyphosphoryl-2,2-dimethyl-propyl)aminoxy]propionamide
  参考文献：
  名称：

  SG1 based alkoxyamines as radical initiators for the synthesis of lactones and lactames

  摘要：

  Recently, it has been shown that alkoxyamines can be used as radical initiators in tin-free radical chemistry. Thus, it prompted us to develop the preparation of highly valuable alkoxyamines via ionic chemistry and the radical cyclization was triggered by thermal initiation. Following that procedure, bicyclic, spiro and eight-membered lactones were easily prepared in good yields with very high stereoselectivity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.06.100

文献信息

• Alkoxyamines derived from beta-phosphorylated nitroxides, and use thereof for preparing polymerized or non-polymerized mono-or polyalkoxyamines
  申请人：Couturier Jean-luc

  公开号：US20050065119A1

  公开（公告）日：2005-03-24

  The invention relates to the use of alkoxyamines of formula (I): for the preparation of polymerized or non-polymerized mono- or polyalkoxyamines of formula (II):

  该发明涉及使用式(I)的烷氧胺来制备式(II)的聚合或非聚合的单烷氧胺或多烷氧胺。
• ALKOXYAMINES DERIVED FROM BETA-PHOSPHORYLATED NITROXIDES, AND USE THEREOF FOR PREPARING POLYMERIZED OR NON-POLYMERIZED MONO- OR POLYALKOXYAMINES
  申请人：Couturier Jean-Luc

  公开号：US20070167591A1

  公开（公告）日：2007-07-19

  The invention relates to the use of alkoxyamines of formula (I): for the preparation of polymerized or non-polymerized mono- or polyalkoxyamines of formula (II):
• US7214810B2
  申请人：——

  公开号：US7214810B2

  公开（公告）日：2007-05-08
• SG1 based alkoxyamines as radical initiators for the synthesis of lactones and lactames
  作者：Denis Bertin、Didier Gigmes、Sylvain R.A. Marque、Paul Tordo

  DOI：10.1016/j.tet.2005.06.100

  日期：2005.9

  Recently, it has been shown that alkoxyamines can be used as radical initiators in tin-free radical chemistry. Thus, it prompted us to develop the preparation of highly valuable alkoxyamines via ionic chemistry and the radical cyclization was triggered by thermal initiation. Following that procedure, bicyclic, spiro and eight-membered lactones were easily prepared in good yields with very high stereoselectivity. (c) 2005 Elsevier Ltd. All rights reserved.