硫代磷酰基-苯氧基甲基(甲基肼)树枝状聚合物,1.5代 | 169132-80-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 中文名称: 硫代磷酰基-苯氧基甲基(甲基肼)树枝状聚合物,1.5代
• 中文别名: 硫代磷酰基-PMMH-6树枝状聚合物,1.5代；硫代磷酰基-苯氧基甲基(甲基肼)-6聚合体1.5代
• 英文名称: G'1
• 英文别名: 4-[[[[4-Bis[4-[[bis(4-formylphenoxy)phosphinothioyl-methylhydrazinylidene]methyl]phenoxy]phosphinothioyloxyphenyl]methylideneamino]-methylamino]-(4-formylphenoxy)phosphinothioyl]oxybenzaldehyde
• CAS: 169132-80-3
• 化学式: C₆₆H₅₄N₆O₁₅P₄S₄
• 分子量: 1423.35
• InChiKey: GVUPCQKZNKROEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.4
• 重原子数：
  95
• 可旋转键数：
  33
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  361
• 氢给体数：
  0
• 氢受体数：
  25

安全信息

• 安全说明：
  S24/25

反应信息

• 作为反应物：
  描述：

  硫代磷酰基-苯氧基甲基(甲基肼)树枝状聚合物,1.5代 在 一水合肼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以92%的产率得到Thiophosphoric acid O,O',O''-tris-(4-{[bis-(4-hydrazonomethyl-phenoxy)-thiophosphoryl]-methyl-hydrazonomethyl}-phenyl) ester
  参考文献：
  名称：

  含磷树枝状聚合物。轻松获得新的多功能化大分子。

  摘要：

  具有末端醛基的含磷树枝状聚合物1- [G'（1）]-1- [G'（4）]（第1代至第4代）与各种肼基化合物反应。将肼本身加至1- [G'（1）]-1- [G'（4）]，得到相应的树枝状聚合物2- [G（1）]-2- [G（4）]，在其上具有基。周边。将甲基肼加到1- [G'（1）]，1- [G'（4）]中得到树枝状聚合物3- [G（1）]，3- [G（4）]。1- [G'（1）]-1- [G'（4）]与1-氨基-4-（2-羟乙基）哌嗪之间的席夫反应导致树枝状聚合物5- [G（1）]-5- [G（4）]拥有多达48个醇链末端。用芴酮hydr处理1- [G'（1）]，1- [G'（3）]产生大分子7- [G（1）]，7- [G（3）]，而1的反应-[G'（1）]，1- [G'（2）]，1- [G'（4）]与4-氨基苯并-15-冠-5一起得到大分子9- [G（1）]， 9- [G（2）]，9-

  DOI：

  10.1021/jo960045b
• 作为产物：
  描述：

  硫代磷基-pmmh-3树枝状聚合物,代1.0 在 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成 硫代磷酰基-苯氧基甲基(甲基肼)树枝状聚合物,1.5代
  参考文献：
  名称：

  Launay, Nathalie; Caminade, Anne-Marie; Lahana, Roger, Angewandte Chemie, 1994, vol. 106, # 15/16, p. 1682 - 1684

  摘要：

  DOI：

文献信息

• Use of Dendrimers to Stimulate Cell Growth
  申请人：Majoral Jean-Pierre

  公开号：US20090142316A1

  公开（公告）日：2009-06-04

  The present invention relates to the use of dendrimers with monophosphonic or bisphosphonic terminations in order to stimulate the growth of cell cultures or to activate cells in culture.

  本发明涉及在细胞培养中使用具有单磷酸或双磷酸端基的树枝状聚合物，以促进细胞培养的生长或激活细胞。
• Pestcide and/or plant growth regulating compositions
  申请人：Caminade Anne-Marie

  公开号：US06939831B1

  公开（公告）日：2005-09-06

  The invention concerns pesticide and/or insecticide and/or plant growth regulating compositions comprising specific dendrimers, said compositions being, in particular, useable for agriculture and/or public health or domestic hygiene; the invention also concerns methods for treating and/or protecting crops and/or for public health and domestic hygiene using said compositions. The invention further concerns specific dendrimers.

  本发明涉及杀虫剂和/或杀虫剂和/或植物生长调节剂组成物，其中包括特定的树状分子，该组成物特别适用于农业和/或公共卫生或家庭卫生；本发明还涉及使用该组成物治疗和/或保护作物和/或公共卫生和家庭卫生的方法。本发明还涉及特定的树状分子。
• MALDI TOF Mass Spectrometry for the Characterization of Phosphorus-Containing Dendrimers. Scope and Limitations
  作者：Jean-Claude Blais、Cédric-Olivier Turrin、Anne-Marie Caminade、Jean-Pierre Majoral

  DOI：10.1021/ac0003854

  日期：2000.10.1

  Neutral phosphorus-containing dendrimers with aldehyde groups at the periphery have been analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) up to generation four. Although the expected quasi-molecular ion is generally observed, the mass spectral pattern, presence of fragments and adducts related to the original skeleton, is highly relevant to the sample preparation (nature of the matrix:  2-5-dihydroxybenzoic acid (2.5-DHB), 1,8-dihydroxy-9[10H]-anthracenone (dithranol), 6-azathiothymine, 2,4,6-trihydroxyacetophenon, 7-hydroxycoumarin or 2-anthramine, and addition of alkali metal salts). The dithranol matrix with addition of LiI offers milder conditions; however, abundant fragments are still observed for the higher generation dendrimers. Investigation of these effects in connection with SEC, NMR, and MALDI-TOFMS studies of UV preirradiated dendrimers allows the assumption to be made that fragmentation occurs in MALDI due to the relatively strong absorption of the dendrimers at 337 nm. Fragmentations and formation of adducts involve nitrogen−nitrogen bond cleavage, imine metathesis, and reaction of aldehyde groups with internal imino groups.

  使用基质辅助激光解吸电离飞行时间质谱（MALDI-TOFMS）对中性含磷树枝状分子外围的醛基进行了分析，分析结果可追溯到第四代。虽然通常可以观察到预期的准分子离子，但质谱图、碎片和与原始骨架相关的加合物的存在与样品制备（基质的性质：2-5-二羟基苯甲酸（2.5-DHB）、1,8-二羟基-9[10H]-蒽酮（二萘酚）、6-氮杂硫代胸苷、2,4,6-三羟基苯乙酮、7-羟基香豆素或2-蒽胺，以及碱金属盐的添加）高度相关。添加LiI的二萘酚基质提供了更温和的条件；然而，对于更高代数的树枝状分子，仍然观察到大量碎片。通过结合SEC、NMR和MALDI-TOFMS对紫外线预照射树枝状分子进行研究，可以推测MALDI中发生碎片化是由于树枝状分子在337 nm处具有相对较强的吸收。碎片化和加合物的形成涉及氮-氮键断裂、亚胺复分解反应以及醛基与内部亚氨基的反应。
• Phosphate-, Phosphite-, Ylide-, and Phosphonate-Terminated Dendrimers
  作者：Delphine Prévôté、Anne-Marie Caminade、Jean Pierre Majoral

  DOI：10.1021/jo9701750

  日期：1997.7.1

  Many types of tri- and tetracoordinated phosphorus derivatives have been grafted on the surface of dendrimers, starting from aldehyde terminal functions. Depending on the solubility of the resulting phosphorylated dendrimers, these experiments have been carried out on generation 1 (six end groups) for phosphate- (4-[G(1)]), phosphinite- (6-[G(1)]), and ylide-teminated (11-[G(1)]) dendrimers and up to generation 5 (96 end groups) for aminophosphate- (8-[G(1)], 8-[G(5)]), aminiphosphite (10-[G(1)], 10-[G(5)]), and functionalized phosphonate-terminated (14-[G(1)]-14-[G(5)], 15-[G(1)], 15-[G(5)], 17-[G(1)], 19-[G(1)], 19-[G(5)]) dendrimers. Most of the phosphonate-terminated dendrimers present an unexpected long-range phosphorus-phosphorus coupling constant through seven bonds (3.8 < (7)Jpp < 4.5 Hz).
• Chiroptical properties of dendrimers with stereogenic end groups
  作者：Marie-Laure Lartigue、Anne-Marie Caminade、Jean Pierre Majoral

  DOI：10.1016/s0957-4166(97)00304-2

  日期：1997.8

  The synthesis of dendrimers with stereogenic end groups 3S-[G(n)] and 3R-[G(n)] (n=1-4, 7), obtained from the condensation of (S)-(-)-alpha-methylbenzylamine, or (R)-(+)-alpha-methylbenzyl amine with aldehyde terminated dendrimers is described up to the seventh generation (up to 384 stereogenic groups). The chemiospecific reduction of the imine bonds thus created affords two new series of stereogenic dendrimers 4S-[G(n)] and 4R-[G(n)] (n=1-4). Then, the reaction with Ph2PCH2OH gives a series of stereogenic phosphino terminated dendrimers 5S-[G(n)] and 5R-[G(n)] (n=1-4). Studies of the chiroptical properties of all these non-hindered stereogenic dendrimers indicate that each terminal group behaves independently and that the specific rotation depends only on the number of stereogenic groups grafted on the dendrimer, whatever the generation is. (C) 1997 Published by Elsevier Science Ltd.