(2S,4R)-[[4-mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetic acid benzyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2S,4R)-[[4-mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetic acid benzyl ester
• 英文别名: Benzyl 2-[methyl-(1-naphthalen-2-ylsulfonyl-4-sulfanylpyrrolidine-2-carbonyl)amino]acetate；benzyl 2-[methyl-(1-naphthalen-2-ylsulfonyl-4-sulfanylpyrrolidine-2-carbonyl)amino]acetate
• 化学式: C₂₅H₂₆N₂O₅S₂
• 分子量: 498.624
• InChiKey: JOIIKWUHAWWJKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  三甲基氯硅烷 、 (2S,4R)-[[4-[5-(Benzyloxycarbonylmethyl-methyl-carbamoyl)-1-(naphthalene-2-sulfonyl)-pyrrolidin-3-yldisulfanyl]-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetic acid benzyl ester 、 (2S,4R)-[[4-(4-methoxy-benzylsulfanyl)-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetic acid benzyl ester 、 三丁基膦 生成 (2S,4R)-[[4-mercapto-1-(naphthalene-2-sulfonyl)-pyrrolidine-2-carbonyl]-methyl-amino]-acetic acid benzyl ester
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Pyrrolidine derivatives
  申请人：——

  公开号：US20020049243A1

  公开（公告）日：2002-04-25

  The present invention relates to pyrrolidine derivatives and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

  本发明涉及吡咯烷衍生物及其二聚体形式和/或药用可接受的酯和/或盐。这些化合物可用作金属蛋白酶抑制剂，例如锌蛋白酶，特别是锌水解酶，对治疗与血管收缩增加发生相关的疾病状态有效。
• PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1303485A1

  公开（公告）日：2003-04-23
• US6541638B2
  申请人：——

  公开号：US6541638B2

  公开（公告）日：2003-04-01
• [EN] PYRROLIDINE DERIVATIVES AS INHIBITORS OF ENDOTHELIN-CONVERTING ENZYME<br/>[FR] DERIVES DE PYRROLIDINE UTILISES COMME INHIBITEURS DE L'ENZYME DE CONVERSION DE L'ENDOTHELINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002006222A1

  公开（公告）日：2002-01-24

  The present invention relates to compounds of formula (I), wherein R1, R2, A, X and m are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors or metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.