dimethylmethyleneammonium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dimethylmethyleneammonium chloride
• 英文别名: N-dimethylmethyleneammonium chloride；N,N-dimethylmethyleneammonium chloride；Propan-2-imine;hydrochloride；propan-2-imine;hydrochloride
• 化学式: C₃H₇N*ClH
• 分子量: 93.5562
• InChiKey: FEQAUBVIUZJXKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.77
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine 、 dimethylmethyleneammonium chloride 生成 dimethyl-(6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-ylmethyl)-amine
  参考文献：
  名称：

  Process for the production of

  摘要：

  一种制备1-[(二甲基氨基)甲基]-6-取代-4H-s-三唑并[4,3-a][1,4]苯二氮杂环庚烯的方法，包括将4H-s-三唑并[4,3-a][1,4]苯二氮杂环庚烯与试剂##STR1## 反应，其中X.sup.-表示一价酸的阴离子。

  公开号：

  US04001262A1

文献信息

• [EN] SORDARIN DERIVATIVES FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY PATHOGENIC MICROORGANISMS<br/>[FR] DÉRIVÉS DE SORDARINE POUR PRÉVENIR OU TRAITER DES MALADIES INFECTIEUSES CAUSÉES PAR DES MICRO-ORGANISMES PATHOGÈNES
  申请人：ASTELLAS PHARMA INC

  公开号：WO2009131246A1

  公开（公告）日：2009-10-29

  This invention relates to a new sordarin derivative or a pharmaceutically acceptable salt thereof, which has antimicrobial activities (especially, antifungal activities), to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases in a human being or an animal.

  这项发明涉及一种新的索达林衍生物或其药用可接受的盐，该衍生物具有抗菌活性（特别是抗真菌活性），其制备方法，包含该衍生物的药物组合物，以及用于预防或治疗人类或动物传染性疾病的方法。
• Dihydro pyrazolopyrroles, compositions and use
  申请人：Pfizer Inc.

  公开号：US05508300A1

  公开（公告）日：1996-04-16

  The compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof; wherein X.sub.1, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, are inhibitors of PDE IV and the production of tumor necrosis factor. As such, they are active in the treatment of inflammatory diseases, shock etc.

  公式为##STR1##的化合物及其药用可接受的盐；其中X.sub.1，R.sup.1，R.sup.2，R.sup.3和R.sup.4如本文所定义，是PDE IV的抑制剂和肿瘤坏死因子的产生。因此，它们在治疗炎症性疾病、休克等方面具有活性。
• Dihydro pyrazolopyrroles
  申请人：Pfizer Inc

  公开号：US05596013A1

  公开（公告）日：1997-01-21

  The compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof; wherein X.sub.1, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein, are inhibitors of PDE IV and the production of tumor necrosis factor. As such, they are active in the treatment of inflammatory diseases, shock etc.

  该式化合物及其药学上可接受的盐，其中X1、R1、R2、R3和R4的定义如本文所述，均为PDE IV酶和肿瘤坏死因子的抑制剂。因此，它们在治疗炎症性疾病、休克等方面具有活性。
• Process for preparing triazolobenzodiazepines
  申请人：The Upjohn Company

  公开号：US04075221A1

  公开（公告）日：1978-02-21

  An improved process for the production of 1-dialkyl-amino-ethyl-6-aryl-4H-s-triazolo[4,3-a][1,4]benzodiazepines of the formula II: ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.2 is hydrogen, methyl or phenyl; wherein the ring A is unsubstituted, or monosubstituted with fluoro, chloro, bromo, nitro, trifluoromethyl or methylthio; and wherein Ar is phenyl; o-chlorophenyl; o-fluorophenyl; 2,6-difluorophenyl or 2-pyridyl, is carried out by reacting a compound of the Formula I: ##STR2## wherein ring A, Ar and R.sub.2 are defined as above, with a dialkylmethyleneammonium salt in the presence of a reactive carboxylic acylating agent. The compounds of Formula II (R.sub.2 .dbd.H) are known compounds (Belgian Pat. No. 782,84g) which have sedative-tranquilizing as well as pronounced anti-depressant activity, suitable for the treatment of anxieties and depressions in mammals, including man.

  一种改进的方法用于制备式II的1-二烷基氨基乙基-6-芳基-4H-s-三唑并[4,3-a][1,4]苯二氮平，其中R.sub.1是1到3个碳原子的烷基，包括；其中R.sub.2是氢，甲基或苯基；其中环A未取代，或单取代为氟，氯，溴，硝基，三氟甲基或甲硫基；而Ar是苯基；o-氯苯基；o-氟苯基；2,6-二氟苯基或2-吡啶基，通过在反应性羧酸酰化剂存在下与式I的化合物反应：其中环A，Ar和R.sub.2如上定义，与二烷基亚甲基铵盐反应。式II的化合物（R.sub.2.dbd.H）是已知化合物（比利时专利号782,84g），具有镇静安定以及明显的抗抑郁活性，适用于治疗哺乳动物，包括人类的焦虑和抑郁症。
• Synthesis of 21-(Dimethylamino)Methyl N-Confused Porphyrin Derivatives by Mannich Reaction
  作者：Bin Liu、Xiaofang Li、Mengting Wang、Rongjin Zeng

  DOI：10.3184/174751913x13846100471836

  日期：2013.12

  The 21-(dimethylamino) methyl N-confused porphyrin derivatives were synthesised by the Mannich reaction of dimethylmethyleneimmonium chloride and N-confused porphyrin. The reaction took place regioselectively in the inner carbon of the inverted pyrrole of N-confused porphyrins.