N,N-diethylamino-ethyl chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-diethylamino-ethyl chloride
• 英文别名: chloroethyldiethylamine；N,N-diethylaminoethyl chloride；N,N-diethylaminoethylchloride；diethylaminoethylchloride；(N,N-diethyl)-1-chloroethylamine；1-chloro-N,N-diethylethanamine
• 化学式: C₆H₁₄ClN
• 分子量: 135.637
• InChiKey: ROXZSHRRSBRWIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-diethylamino-ethyl chloride 、 sodium salt of 3-o-hydroxyphenoxy-4-phenyl-3-butene-2-one 以 水 、 丙酮 为溶剂， 生成 3-丁烯-2-酮,3-[2-[2-(二乙胺基)乙氧基]苯氧基]-4-苯基-,(Z)-
  参考文献：
  名称：

  Phenoxyalkylamines

  摘要：

  这项发明提供了一类具有有趣药理特性的新型氨基烷氧基苯氧基烯酮。

  公开号：

  US03988475A1
• 作为产物：
  描述：

  氯仿 、 1-diethylamino-ethyl 以 乙腈 为溶剂， 生成 N,N-diethylamino-ethyl chloride 、 dichloromethyl radical
  参考文献：
  名称：

  氨基烷基与烷基卤之间的卤素夺取反应：异常的高速率常数

  摘要：

  首次报道了氨基烷基自由基对卤素提取反应的极高反应活性。与CCl 4和CBr 4的反应速率常数接近扩散极限：它们比以前为典型烷基确定的常数高约4-5个数量级。使用分子轨道（MO）计算可以更好地理解这种异常行为。极性效应的参与是直接证据。这种方法对于设计新的还原剂可能很有用。

  DOI：

  10.1016/j.cplett.2008.02.052

文献信息

• Algicidal composition and method of preventing or controlling algae with
  申请人：Duphar International Research B.V.

  公开号：US04286983A1

  公开（公告）日：1981-09-01

  Algicidal composition comprising in an algicidally effective amount a diamine of the formula ##STR1## wherein R.sub.1 is hydrogen or up to three substituents such as halogen, alkyl, phenoxy, phenylthio, or halogen substituted alkoxy, R.sub.2 is hydrogen or a substituent such as alkyl, phenyl, halogen substituted phenyl or a trifluoromethyl-substituted phenyl group, R.sub.3 is an alkylene of 2 to 6 carbon atoms, R.sub.4 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sub.5 is alkyl of 1 to 6 carbon atoms or R.sub.4 and R.sub.5 are together tetramethylene or pentamethylene or R.sub.2 and R.sub.5 are together ethylene and where R.sub.1 is other than three halogen atoms.

  杀藻组合物包括具有杀藻效果的二胺，其化学式为##STR1##其中R.sub.1是氢或最多三个取代基，如卤素、烷基、苯氧基、苯硫基或卤素取代的烷氧基，R.sub.2是氢或取代基，如烷基、苯基、卤素取代的苯基或三氟甲基取代的苯基，R.sub.3是2至6个碳原子的烷基，R.sub.4是氢或1至4个碳原子的烷基，R.sub.5是1至6个碳原子的烷基或R.sub.4和R.sub.5一起是四亚甲基或五亚甲基，或R.sub.2和R.sub.5一起是乙烯，其中R.sub.1不是三个卤素原子。
• Novel substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
  申请人：——

  公开号：US20030073842A1

  公开（公告）日：2003-04-17

  The invention is directed to substituted benzimidazol-2-ones of Formula I, 1 wherein A, X, Y, m, n, R 1 , R 2 , R 3 , R 4 , and R 5 are as described in the specification, which are useful as vasopressin receptor antagonists or Neuropeptide Y Modulators for treating conditions such as aggression, obsessive-compulsive disorders, hypertension, dysmenorrhea, congestive heart failure/cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, edema, ischemia, stroke, thrombosis, water retention, nephrotic syndrome, central nervous injuries, obesity, anorexia, hyperglycemia, diabetes, anxiety, depression, asthma, memory loss, sexual dysfunction, disorders of sleep and other circadian rhythms, and Cushing's disease.

  该发明涉及Formula I的取代苯并咪唑酮，其中A、X、Y、m、n、R1、R2、R3、R4和R5如说明书中所述，其可用作抗利尿素受体拮抗剂或神经肽Y调节剂，用于治疗侵略性、强迫症障碍、高血压、痛经、充血性心力衰竭/心脏不全、冠状动脉痉挛、心肌缺血、肝硬化、肾血管痉挛、肾功能衰竭、水肿、缺血、中风、血栓形成、水潴留、肾症候群、中枢神经损伤、肥胖、厌食、高血糖、糖尿病、焦虑、抑郁、哮喘、记忆丧失、性功能障碍、睡眠障碍和其他生物钟紊乱症状，以及库欣综合征。
• 2-OR 3 KETO-3-OR-2-PHENYL-1,4-DISUBSTITUTED PIPERAZINES
  申请人：Donau-Pharmazie Gesellschaft m.b.H.

  公开号：US03935214A1

  公开（公告）日：1976-01-27

  Novel 1,4-substituted phenyl piperazine compounds have a pronounced effect upon blood coagulation and are useful in the treatment of thrombotic diseases, especially of the arterial system. They are particularly used to inhibit thrombosis of the coronary or cerebral arteries. Examples of such compounds are 1-phenyl (lower) alkyl-2-phenyl-3-keto-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-2-keto-3-phenyl-4-di-(lower)alkylamino (lower)alkyl piperazines, 1-phenyl (lower) alkyl-2-phenyl-4-di-alkylamino (lower)alkyl piperazines, 1-phenyl (lower)alkyl-3-phenyl-4-di-(lower)-alkylamino (lower)alkyl piperazines and their pharmaceutically acceptable acid addition salts. The phenyl ring in 1-position may be substituted by halogen, trifluoro (lower)alkyl, lower alkoxy, or phenyl lower alkoxy; the di-(lower)alkylamino (lower)alkyl group in 4-position may be replaced by piperidino (lower)alkyl, morpholino (lower)alkyl, pyrrolidino (lower alkyl, piperazino (lower)alkyl, or the like mononuclear nitrogen-containing heterocyclically substituted (lower)alkyl.

  1,4-取代苯基哌嗪化合物对血液凝固具有显著影响，并且在治疗血栓性疾病，尤其是动脉系统的治疗中非常有用。它们特别用于抑制冠状动脉或脑动脉的血栓形成。这类化合物的示例包括1-苯基（较低）烷基-2-苯基-3-酮基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-酮基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-2-苯基-4-双烷基氨基（较低）烷基哌嗪，1-苯基（较低）烷基-3-苯基-4-双（较低）烷基氨基（较低）烷基哌嗪及其药学上可接受的酸盐。1-位置的苯环可能被卤素、三氟（较低）烷基、较低烷氧基或苯基较低烷氧基取代；4-位置的双（较低）烷氨基（较低）烷基基团可能被哌啶（较低）烷基、吗啉（较低）烷基、吡咯啉（较低）烷基、哌嗪（较低）烷基等单核氮杂环取代（较低）烷基所替代。
• [EN] MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF<br/>[FR] MODULATEURS DU RECEPTEUR GLUCOCORTICOIDE AP-1, ET/OU DE L'ACTIVITE DE NF- DOLLAR G(K)B, ET LEUR UTILISATION
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2005072732A1

  公开（公告）日：2005-08-11

  A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-ĸB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Z is CONR1R2 or CH2NR1R2 and where at least one of X1 - X8 is N, and R, Ra, Rb, Rc and Rd are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  提供了一类新型非类固醇化合物，可用于治疗与糖皮质激素受体、AP-1和/或NF-ĸB活性调节相关的疾病，包括肥胖、糖尿病、炎症和免疫性疾病，其结构如公式（I）所示，其立体异构体，或其溶剂化物，或其前药，或其药用可接受盐，其中Z为CONR1R2或CH2NR1R2，其中至少一个X1-X8为N，R、Ra、Rb、Rc和Rd在此处定义。还提供了包含所述化合物的药物组合物和治疗肥胖、糖尿病和炎症或免疫相关疾病的方法。
• 2-Substituted benzodioxoles
  申请人：Istituto Luso Farmaco d'Italia S.r.l.

  公开号：US03969368A1

  公开（公告）日：1976-07-13

  2-Substituted benzodioxoles are useful as pharmaceuticals having e.g. anti-inflammatory, analgesic, antipyrretic, antitussive, C.N.S. depressant, local anaesthetic, antiarrythmic, antihistaminic action and hypolipidic action.

  2-取代苯二氧杂环己烷对药物具有多种作用，例如抗炎、镇痛、退热、镇咳、中枢神经系统抑制剂、局部麻醉剂、抗心律失常、抗组胺作用和降脂作用。