苯并[c][2,7]萘啶 | 229-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 苯并[c][2,7]萘啶
• 英文名称: benzo-2,7-naphthyridine
• 英文别名: Benzo[c][2,7]naphthyridine
• CAS: 229-89-0
• 化学式: C₁₂H₈N₂
• 分子量: 180.209
• InChiKey: QYRDMMPTTNOOMH-UHFFFAOYSA-N

物化性质

• 沸点：
  381.7±15.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)
• 熔点：
  140-145 °C(Solv: methanol (67-56-1))

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯并[c][2,7]萘啶 在 正丁基锂 、 四甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成
  参考文献：
  名称：

  Regioselective Nucleophilic Aromatic Substitution of Benzo[c][2,7]naphthyridines

  摘要：

  DOI：

  10.1080/00304941003676895
• 作为产物：
  描述：

  3-溴-5-氯甲基吡啶盐酸盐 在 manganese(IV) oxide 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醇 、 氯仿 为溶剂， 反应 62.0h， 生成 苯并[c][2,7]萘啶
  参考文献：
  名称：

  Nutaitis, Charles F.; Ledeboer, Mark W., Organic Preparations and Procedures International, 1992, vol. 24, # 2, p. 143 - 146

  摘要：

  DOI：

文献信息

• [EN] NOVEL ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS ÉLECTROLUMINESCENTS ORGANIQUES ET DISPOSITIF ÉLECTROLUMINESCENT ORGANIQUE LES UTILISANT
  申请人：ROHM & HAAS ELECT MAT

  公开号：WO2011105700A1

  公开（公告）日：2011-09-01

  Provided are novel organic electroluminescent compounds, and organic electroluminescent devices comprising the same. Since the organic electroluminescent compounds exhibit high luminous efficiency in blue color, and excellent life property of the material, they may be used to manufacture OLEDs having very good operation life.

  提供了新颖的有机电致发光化合物，以及包含这些化合物的有机电致发光器件。由于这些有机电致发光化合物在蓝色方面表现出高发光效率，并且材料具有优秀的寿命特性，因此它们可以用于制造具有非常良好使用寿命的OLED。
• ORGANIC COMPOUND, THREE-DIMENSIONAL ORGANIC FRAMEWORK FORMED BY USING ORGANIC COMPOUND, SEPARATION SIEVE AND OPTICAL LAYER, WHICH COMPRISE ORGANIC FRAMEWORK, AND OPTICAL DEVICE COMPRISING OPTICAL LAYER AS OPTICAL AMPLIFICATION LAYER
  申请人：INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

  公开号：US20190031586A1

  公开（公告）日：2019-01-31

  An organic compound, a three-dimensional organic structure formed by using the organic compound, a separation sieve and an optical layer having the organic structure, and an optical device having the optical layer as an optical amplification layer are provided. The organic structure includes a plurality of organic molecules self-assembled by non-covalent bonding. Each of the unit organic molecules has an aromatic ring, a first pair of substituents being connected to immediately adjacent positions of substitutable positions of the aromatic ring, and a second pair of substituents being connected to immediately adjacent positions of remaining substitutable positions of the aromatic ring. The unit organic molecules are self-assembled by van der Waals interaction, London dispersion interaction or hydrogen bonding between the first and the second pairs of the substituents and by pi-pi interactions between the aromatic rings.

  提供一种有机化合物，通过使用该有机化合物形成的三维有机结构、分离筛和具有该有机结构的光学层，以及具有光学层作为光学放大层的光学器件。该有机结构包括通过非共价键自组装的多个有机分子。每个单元有机分子具有芳香环，第一对取代基连接到芳香环的可取代位置的相邻位置，第二对取代基连接到芳香环的剩余可取代位置的相邻位置。单元有机分子通过范德华力相互作用、伦敦分散相互作用或氢键作用于第一和第二对取代基之间的π-π相互作用而自组装。
• Synthesis of benzo[c]-2,7-naphthyridines by palladium-catalyzed coupling of pyridine methylstannanes with ortho bromoacetanilides in the presence of copper(II)oxide
  作者：Johan Malm、Patrick Björk、Salo Gronowitz、Anna-Britta Hörnfeldt

  DOI：10.1016/s0040-4039(00)76865-1

  日期：1994.5

  benzo[c]-2,7-naphthyridine have been prepared in fair to excellent yields and in one step by the Pd(0)-catalyzed cross-coupling of pyridine methylstannanes with ortho bromoacetanilides. The coupling is greatly promoted by the addition of copper(II)oxide.

  苯并[c] -2,7-萘啶的衍生物已经以相当高的收率制备，并且一步法通过吡啶（甲基）吡啶（Pd（0））催化的吡啶甲基锡烷与邻溴乙酰苯胺的交叉偶联而制备。通过加入氧化铜（II）极大地促进了偶联。
• Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof
  申请人：WISSNER Allan

  公开号：US20080293712A1

  公开（公告）日：2008-11-27

  The present invention relates to Benzo[c][2,7]naphthyridine Derivatives, compositions comprising an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for treating or preventing a proliferative disorder or an autoimmune disease, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for modulating PDK-1 activity, PKA activity, Akt activity, S6K activity, or PKC activity, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative. The invention also relates to processes for preparing a Benzo[c][2,7]naphthyridine Derivative.

  本发明涉及苯并[c][2,7]萘啉衍生物，包含有效量苯并[c][2,7]萘啉衍生物的组合物，用于治疗或预防增殖性疾病或自身免疫疾病的方法，包括向需要治疗的受体内给予有效量的苯并[c][2,7]萘啉衍生物，用于调节PDK-1活性、PKA活性、Akt活性、S6K活性或PKC活性的方法，包括向需要治疗的受体内给予有效量的苯并[c][2,7]萘啉衍生物。本发明还涉及制备苯并[c][2,7]萘啉衍生物的过程。
• PLATINUM COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
  申请人：Blend Therapeutics

  公开号：US20140088066A1

  公开（公告）日：2014-03-27

  The present disclosure relates to novel pharmaceutical compositions comprising a nanoparticle associated with, tether to, or encapsulating a platinum-based active pharmaceutical agent. The platinum-based drug is released from the nanoparticles in a controlled fashion. Also contemplated are methods of making the nanoparticles, as well as methods for using them in the treatment or prevention of diseases or conditions. One embodiment relates to phenanthriplatin nanoparticles and methods of using and making the same.

  本公开涉及新型药物组合物，包括与铂类活性药物相关联、连接或封装的纳米颗粒。铂类药物从纳米颗粒中以受控的方式释放。还考虑了制备纳米颗粒的方法，以及在治疗或预防疾病或病症中使用它们的方法。其中一种实施形式涉及苯并芘铂纳米颗粒及其制备和使用方法。