The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which comprises an enzymatic alcoholysis reaction.
Furthermore, the present invention refers to new crystalline forms of cortexolone 17α-propionate and 9,11-dehydro-cortexolone 17α-butanoate.
本发明涉及一种新的酶法工艺,用于从相应的17α,21-二酯出发获得
皮质酮17α-单酯和/或其9,11-去氢衍
生物的工艺,其中包括酶催化的醇解反应。此外,本发明涉及
皮质酮17α-
丙酸酯和9,11-去氢
皮质酮17α-
丁酸酯的新晶体形式。