2-hydroxy-3-methoxymandelic acid | 71857-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-hydroxy-3-methoxymandelic acid
• 英文别名: OMA；2-Hydroxy-3-methoxy mandelic acid；2-hydroxy-2-(2-hydroxy-3-methoxyphenyl)acetic acid
• CAS: 71857-06-2
• 化学式: C₉H₁₀O₅
• 分子量: 198.175
• InChiKey: SYMPFBURZFGXAS-UHFFFAOYSA-N

物化性质

• 沸点：
  414.5±45.0 °C(Predicted)
• 密度：
  1.440±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  邻苯二酚 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 2.0h， 生成 2-hydroxy-3-methoxymandelic acid 、 2-羟基-3-甲氧基-1,5-二扁桃酸 、 3-甲氧基-4-羟基扁桃酸
  参考文献：
  名称：

  Method for producing alkoxy-hydroxybenzaldehyde that is substantially free of alkyl-alkoxy-hydroxybenzaldehyde

  摘要：

  该发明涉及一种从至少一种羟基苯酚（HP）生产至少一种烷氧基-羟基苯甲醛（AHBA）的方法，其特征在于包括形成至少一种烷氧基苯酚（AP）和烷基烷氧基苯酚（AAP），并将AP与AAP分离（S），所述分离（S）在获得AHBA之前进行。

  公开号：

  US20150203428A1

文献信息

• Method for separating mandelic compounds in salified form and use of same for preparing aromatic aldehyde
  申请人：RHODIA OPERATIONS

  公开号：US20160318839A1

  公开（公告）日：2016-11-03

  The invention describes a method for separating a mandelic compound in salified form from an aqueous reaction medium resulting from the condensation reaction of a hydroxylated aromatic compound with glyoxylic acid in a basic medium, said method comprising a) decanting said reaction medium in such a way as to recover an organic phase formed from the excess of said aromatic compound and an aqueous phase formed from said mandelic compound and a quantity of the excess of said aromatic compound and b) bringing said aqueous phase into contact with an adsorbent support, resulting in the selective adsorption of said aromatic compound and the recovery of an aqueous flow comprising said mandelic compound in salified form, which is subjected to an oxidation step before being converted into hydroxyaromatic aldehyde by electrodialysis.

  该发明描述了一种从含盐形式的苯甲酸类化合物中分离的方法，该化合物是从在碱性介质中羟基芳香化合物与乙醛酸进行缩合反应所得的水相反应介质中分离出来的。该方法包括a) 将所述反应介质倾析，以便从所述芳香化合物的过量形成的有机相和从所述苯甲酸类化合物及所述芳香化合物的过量量形成的水相中回收；b) 将所述水相与吸附支撑物接触，导致选择性吸附所述芳香化合物并回收含盐形式的所述苯甲酸类化合物的水流，然后在将其转化为羟基芳香醛之前，通过电渗析进行氧化处理。
• Method for preparing p-hydroxymandelic compounds optionally substituted
  申请人：Rhodia Chimie

  公开号：US06753441B1

  公开（公告）日：2004-06-22

  The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives. More particularly, it concerns a method for preparing p-hydroxymandelic acid and methoxy-3 p-hydroxymandelic acid and their derivatives. The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives, which consists in condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least a hydroxyl group and whereof the position in para is free, with glyoxylic acid, said method being characterised in that the reaction is carried out in the presence of an efficient amount of a compound bearing at least two carboxylic functions.

  这项发明涉及一种制备p-羟基曼德酸化合物及其衍生物的方法。更具体地说，涉及一种制备p-羟基曼德酸和甲氧基-3 p-羟基曼德酸及其衍生物的方法。这项发明涉及一种制备可选替代的p-羟基曼德酸化合物及其衍生物的方法，包括在水中，在碱性试剂的存在下，使至少带有一个羟基的芳香化合物与乙醛酸缩合，所述方法的特征在于在至少含有两个羧基功能的化合物的有效量存在下进行反应。
• METHOD FOR PREPARING OPTIONALLY SUBSTITUTED P-HYDROXYMANDELIC COMPOUNDS AND DERIVATIVES THEREOF
  申请人：Heinisch Bruno

  公开号：US20110009664A1

  公开（公告）日：2011-01-13

  The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor.

  该发明涉及一种制备可选择取代的P-羟基苯乙酸化合物及其衍生物的方法。该发明的制备苯乙酸化合物的方法包括在水中，在碱性剂的存在下，将至少含有一个羟基且具有一个自由对位的芳香化合物与乙醛酸缩合，其中所述方法的特征在于该反应是在活塞流反应器中进行的。
• METHOD FOR SEPARATING SALIFIED PHENOLIC COMPOUNDS
  申请人：Desouhant-Massacret Magali

  公开号：US20120264982A1

  公开（公告）日：2012-10-18

  A method for separating a salified phenolic compound from a reaction medium including same is described. Also described, is a method for separating salified phenolic compounds from an aqueous reaction medium resulting from the reaction of a phenolic compound and glyoxylic acid in the presence of a base, which leads to a reaction medium including at least the excess of the starting salified phenolic compound and the various salified mandelic compounds resulting from the reaction, wherein the reaction medium including the starting salified phenolic compound is contacted with an adsorbent substrate. This leads to the selective adsorption of the phenolic compound onto said substrate and to the recovery of an aqueous flow containing the salified mandelic compounds from the reaction, and in that the phenolic compound attached onto the adsorbent is desorbed by means of a regenerating treatment of the adsorbent.

  描述了一种从包括同样的反应介质中分离盐化酚类化合物的方法。还描述了一种从含有酚类化合物和乙酰乙酸反应产生的水相反应介质中分离盐化酚类化合物的方法，在这种情况下，反应介质至少包括起始盐化酚类化合物的过量和反应产生的各种盐化曼德酸化合物，其中包括起始盐化酚类化合物的反应介质与吸附基质接触。这导致酚类化合物选择性地吸附到所述基质上，并从反应中回收含有盐化曼德酸化合物的水流，而附着在吸附剂上的酚类化合物通过吸附剂的再生处理脱附。
• LIGAND-ANKER-KONJUGATE ZUR GENERIERUNG EINER BIOSENSOR-SCHICHT
  申请人：Graffinity Pharmaceuticals Aktiengesellschaft

  公开号：EP1185869B1

  公开（公告）日：2006-07-26