erythrosin B diacetate | 77084-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: erythrosin B diacetate
• 英文别名: 3',6'-diacetoxy-2',4',5',7'-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one；3',6'-Diacetoxy-2',4',5',7'-tetrajod-spiro[phthalan-1,9'-xanthen]-3-on；(6'-Acetyloxy-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate；(6'-acetyloxy-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) acetate
• CAS: 77084-69-6
• 化学式: C₂₄H₁₂I₄O₇
• 分子量: 919.973
• InChiKey: AYCGKLGGWSLCPM-UHFFFAOYSA-N

物化性质

• 沸点：
  785.8±60.0 °C(Predicted)
• 密度：
  2.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium acetate 、 乙酸酐 作用下， 生成 erythrosin B diacetate
  参考文献：
  名称：

  Dolinsky; Jones, Journal of the Association of Official Agricultural Chemists, 1951, vol. 34, p. 114,115

  摘要：

  DOI：

文献信息

• [EN] SINGLET OXYGEN-LABILE LINKERS AND METHODS OF PRODUCTION AND USE THEREOF<br/>[FR] LIEURS LABILES À L'OXYGÈNE SINGULET ET PROCÉDÉS DE PRODUCTION ET D'UTILISATION ASSOCIÉS
  申请人：YOU YOUNGJAE

  公开号：WO2013163321A1

  公开（公告）日：2013-10-31

  Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

  公开了包含至少一个功能基团和至少一个可裂解连接剂的激活组合物，该连接剂直接或间接地与至少一个功能基团相连。当功能基团与连接剂相连时，它是非活性的，在连接剂裂解时被激活。还公开了生产和使用这种激活组合物的方法。
• SINGLET OXYGEN-LABILE LINKERS AND METHODS OF PRODUCTION AND USE THEREOF
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20150165026A1

  公开（公告）日：2015-06-18

  Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

  本发明揭示了包括至少一个功能性基团和至少一个可断裂连接基团的可活化组合物，该可断裂连接基团直接或间接连接至少一个功能性基团。当连接到连接基团时，至少一个功能性基团是不活性的，并在连接基团被断裂时被激活。本发明还揭示了制备和使用该可活化组合物的方法。
• Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging
  作者：Wen Chyan、Henry R. Kilgore、Brian Gold、Ronald T. Raines

  DOI：10.1021/acs.joc.7b00285

  日期：2017.4.21

  Fluorogenic probes are invaluable tools for spatiotemporal investigations within live cells. In common fluorogenic probes, the intrinsic fluorescence of a small-molecule fluorophore is masked by esterification until entry into a cell, where endogenous esterases catalyze the hydrolysis of the masking groups, generating fluorescence: The-susceptibility of masking groups to spontaneous hydrolysis is a major limitation of these probes. Previous attempts to address this problem have incorporated auto-immolativo linkers at the cost of atom economy and synthetic adversity. Here, we report on a linker-free strategy that employs adventitious electronic and steric interactions in easy-to-synthesize probes. We find that X center dot center dot center dot C=O n ->pi* interactions and acyl group size are optimized in 2 ',7 '-dichlorofluorescein diisobutyrate. This probe is relatively stable to spontaneous hydrolysis but is a highly reactive substrate for esterases both in vitro and in cellulo, yielding a bright, photostable fluorophore with utility in biomolecular imaging.
• Gomberg; Tabern, Journal of Industrial and Engineering Chemistry, 1922, vol. 14, p. 1116
  作者：Gomberg、Tabern

  DOI：——

  日期：——
• Singlet Oxygen-Labile Linkers and Methods of Production and Use Thereof
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20170014510A1

  公开（公告）日：2017-01-19

  Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.