(R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester | 1204978-36-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester
• 英文别名: (R)-4-(6-Chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H [1,2']bipyrazinyl-5'-carboxylic acid methyl ester；methyl 5-[(2R)-4-(6-chloro-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]pyrazine-2-carboxylate
• CAS: 1204978-36-8
• 化学式: C₁₇H₂₁ClN₆O₂
• 分子量: 376.846
• InChiKey: DDNVIFMIDNVROU-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  84.3
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester 在 potassium phosphate 、 palladium diacetate 、 2-二-叔丁膦基-2',4',6'-三异丙基联苯 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 19.5h， 生成 2-[(R)-4-(4,5-dimethyl-6-phenoxy-pyridazin-3-yl)-2-methyl-3,4,5,6-tetra-hydro-2H-[1,2']bipyrazinyl-5'-yl]propan-2-ol
  参考文献：
  名称：

  NVP-LEQ506，第二代平滑化抑制剂的发现

  摘要：

  首次公开：持续的优化提供了一种基于哒嗪核心的新型平滑（Smo）拮抗剂。NVP‐LEQ506化合物目前处于I期临床试验中，具有很高的内在效价和良好的药代动力学特性，在髓母细胞瘤的啮齿动物肿瘤模型中具有出色的疗效。在先前的临床试验中观察到的与竞争性化合物对抗Smo突变的耐药性的活性表明其具有更大的治疗潜力。

  DOI：

  10.1002/cmdc.201300217
• 作为产物：
  描述：

  3,6-二氯-4,5-二甲基哒嗪 在 potassium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 (R)-4-(6-chloro-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid methyl ester
  参考文献：
  名称：

  NVP-LEQ506，第二代平滑化抑制剂的发现

  摘要：

  首次公开：持续的优化提供了一种基于哒嗪核心的新型平滑（Smo）拮抗剂。NVP‐LEQ506化合物目前处于I期临床试验中，具有很高的内在效价和良好的药代动力学特性，在髓母细胞瘤的啮齿动物肿瘤模型中具有出色的疗效。在先前的临床试验中观察到的与竞争性化合物对抗Smo突变的耐药性的活性表明其具有更大的治疗潜力。

  DOI：

  10.1002/cmdc.201300217

文献信息

• Organic Compounds as Smo Inhibitors
  申请人：HE Feng

  公开号：US20100041663A1

  公开（公告）日：2010-02-18

  The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

  本发明一般涉及与Hedgehog通路相关的病理诊断和治疗的新化合物，包括但不限于肿瘤形成、癌症、肿瘤和非恶性过度增殖性疾病。本发明包括新化合物、新组合物、它们的使用方法和制备方法，这些化合物通常在药理学上作为治疗剂是有用的，其作用机制涉及通过抑制Hedgehog和Smo信号通路的方法来抑制肿瘤发生、肿瘤生长和肿瘤存活。
• Pyridazinyl derivatives as smo inhibitors
  申请人：He Feng

  公开号：US08481542B2

  公开（公告）日：2013-07-09

  The present invention relates to compounds of formula I: in which R11 and R12 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.

  本发明涉及式I的化合物：其中R11和R12在本发明摘要中定义；能够抑制Hedgehog和Smo信号通路。本发明还提供了一种制备本发明化合物的方法，包括这种化合物的制药制剂以及使用这种化合物和组合物在诊断和治疗与Hedgehog和Smo信号通路相关的病理学，例如肿瘤形成，癌症，新生物和非恶性增生性疾病的方法。
• [EN] PYRIDAZINE DERIVATIVES AS SMO INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDAZINE EN TANT QU'INHIBITEURS DE SMO
  申请人：NOVARTIS AG

  公开号：WO2010007120A1

  公开（公告）日：2010-01-21

  The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

  本发明涉及与Hedgehog通路相关的病理诊断和治疗的新化合物，包括但不限于肿瘤形成、癌症、肿瘤新生和非恶性高增殖性疾病。本发明包括新的化合物、新的组合物、它们的使用方法和制造方法，其中这些化合物通常作为药理学上有用的治疗剂，其作用机制涉及使用抑制Hedgehog和Smo信号通路的剂量来抑制肿瘤发生、肿瘤生长和肿瘤存活的方法。
• ORGANIC COMPOUNDS AS SMO INHIBITORS
  申请人：HE Feng

  公开号：US20120289507A1

  公开（公告）日：2012-11-15

  The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.

  本发明涉及与Hedgehog通路相关的病理诊断和治疗的新化合物，包括但不限于肿瘤形成、癌症、肿瘤新生和非恶性过度增殖性疾病。本发明包括新化合物、新组合物、它们的使用方法和制备方法，这些化合物通常在药理学上可用作抑制肿瘤发生、肿瘤生长和肿瘤存活的治疗剂，其机制涉及抑制Hedgehog和Smo信号通路的方法。
• PYRIDAZINYL DERIVATIVES AS SMO INHIBITORS
  申请人：He Feng

  公开号：US20130261299A1

  公开（公告）日：2013-10-03

  The present invention relates to compounds of formula I: in which L, W, X, Y, Z, m, p, R1, R2, R3, R4 and R7 are defined in the Summary of the Invention; capable of inhibiting the Hedgehog and Smo signaling pathway. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the diagnosis and treatment of pathologies relating to the Hedgehog and Smo signaling pathway, for example, tumor formation, cancer, neoplasia and non-malignant hyperproliferative disorders.

  本发明涉及式I的化合物：其中L、W、X、Y、Z、m、p、R1、R2、R3、R4和R7在发明摘要中被定义；能够抑制Hedgehog和Smo信号通路。本发明还提供了一种制备本发明化合物的方法，包括含有这种化合物的制药制剂以及在与Hedgehog和Smo信号通路相关的病理学诊断和治疗中使用这种化合物和组合物的方法，例如肿瘤形成、癌症、肿瘤新生和非恶性增殖性疾病。