perfluoro-n-propylcyclohexane | 374-59-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: perfluoro-n-propylcyclohexane
• 英文别名: Perfluor-n-propylcyclohexan；Undecafluoro(heptafluoropropyl)cyclohexane；1,1,2,2,3,3,4,4,5,5,6-undecafluoro-6-(1,1,2,2,3,3,3-heptafluoropropyl)cyclohexane
• CAS: 374-59-4
• 化学式: C₉F₁₈
• 分子量: 450.07
• InChiKey: ITPKQVFBLQIXLT-UHFFFAOYSA-N

物化性质

• 沸点：
  123.05°C (rough estimate)
• 密度：
  1.888 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  正丙基环己烷 在 cobalt (III) fluoride 作用下， 生成 perfluoro-n-propylcyclohexane
  参考文献：
  名称：

  715.有机氟化物。第五部分：三氟化钴对烃类的氟化

  摘要：

  DOI：

  10.1039/jr9500003617

文献信息

• Free radical chemistry. Part 5. [1] A new approach to the synthesis of perfluorinated ethers
  作者：Richard D. Chambers、Brian Grievson、Frederick G. Drakesmith、Richard L. Powell

  DOI：10.1016/s0022-1139(00)82331-3

  日期：1985.9

  Fluorinations of the free-radical adducts of fluorinated alkenes, to ethers, over cobalt trifluoride are described and perfluorinated ethers are obtained at temperatures in excess of 400°C. The effect of structure on the formation of perfluoroethers is outlined.

  描述了在三氟化钴上氟化烯烃的自由基加合物向醚的氟化，并且在超过400°C的温度下获得了全氟化醚。概述了结构对全氟醚形成的影响。
• Free radical chemistry. Part 10. Addition of acyclic and cyclic alkanes to hexafluoropropene
  作者：Richard D. Chambers、Robert W. Fuss、Robert C. H. Spink、Martin P. Greenhall、Alan M. Kenwright、Andrei S. Batsanov、Judith A. K. Howard

  DOI：10.1039/a909777e

  日期：——

  reactions of acyclic and cyclic alkanes with hexafluoropropene are described. A variety of perfluorocarbons and polyfluorinated alkenes, di-enes and a tetra-ene were synthesised from these polyfluoroalkylated alkanes. Elimination of hydrogen fluoride gives fluorinated alkenes, with unusual kinetic control of product formation and further fluorinations gave novel perfluorocarbons. X-Ray crystallography

  γ射线或 过氧化物 引发的非环和环反应 烷烃 和 六氟丙烯被描述。各种全氟化碳和多氟化碳烯烃，由这些多氟烷基化合成二烯和四烯 烷烃。消除氟化氢 产生氟化 烯烃，通过异常的动力学控制产物的形成和进一步的氟化反应，得到了新颖的全氟化碳。 X射线晶体学 某些异构体的既定结构和 核磁共振波谱 主要用于建立其他人的结构。
• Synthesis of perfluorochemicals for use as blood substitutes, Part I. Electrochemical fluorination of N-methyldecahydroquinoline and N-methyldecahydroisoquinoline
  作者：Youichiro Naito、Yoshihisa Inoue、Taizo Ono、Yoshio Arakawa、Chikara Fukaya、Kazumasa Yokoyama、Yoshiro Kobayashi、Kouichi Yamanouchi

  DOI：10.1016/s0022-1139(00)80976-8

  日期：1984.12

  Electrochemical fluorination of N-methyldecahydroquinoline afforded mainly a mixture of and N-(F-methyl)-F-decahydroquinoline, their rearranged isomers and F-propyl-F-cyclohexane arising from the cleavage at carbon-nitrogen bonds, in a ratio of approximately 2:4:6:3. N-Methyldecahydroisoquinoline was also fluorinated electrochemically to give a mixture of and N-(F-methyl)-F-decahydroisoquinoline, their

  的N- methyldecahydroquinoline的电化学氟化，得到主要是的混合物和N-（F-甲基）-F-十氢喹啉，它们的重排的异构体和从碳-氮键的断裂产生的F-丙基-F-环己烷，在大约一个比2：4：6：3。的N- Methyldecahydroisoquinoline也电化学氟化，得到的混合物和N-（F-甲基）-F-十氢异喹，它们的重排的异构体和1-（F -乙基）-2-（F -甲基）在-F环己烷比率约为4：4：6：1。在起始原料的和比例与相应的全氟化胺的比例之间没有发现相关性。N-甲基-1,2,3,4-四氢喹啉的氟化产生的产率低得多。
• EMULSION OF PERFLUORORGANIC COMPOUNDS FOR MEDICAL PURPOSES, METHOD FOR PRODUCING SAID EMULSION AND METHODS FOR CURING AND PREVENTING DISEASES WITH THE AID OF THE EMULSION
  申请人：Otkrytoe Aktsionernoe Obchestvo Nauchno-Proizvodstvennaya Firma "Perftoran"

  公开号：EP1306083A1

  公开（公告）日：2003-05-02

  An emulsion of perfluoroorganic compounds (PFOCs) with gas-transporting properties for intravascular administration comprises a perfluorocarbon rapidly eliminable from the organism and a perfluorinated tertiary amine slowly eliminable from the organism and further comprises at least three kinds of PFOC admixtures taken in small amounts, which are close in their structure and physicochemical properties to the main components and make up a series of PFOCs with gradually changing properties. The emulsion also contains minor admixtures of H-perfluoroalkanes. Such a composition contributes to the formation of a more homogeneous and stable non-clustered perfluorocarbon phase inside the emulsion particles. The PFOC emulsion is stabilized by a polyoxyethylene-polyoxypropylene copolymer. The formulation of the composition provides stability of the emulsion under storage and on entry into the blood flow, as well as a low viscosity of the PFOC emulsion, which secures a high dynamic oxygen capacity of the preparation and improves the delivery of oxygen to tissues. When preparing the emulsion, the stabilizing agent is heated at a temperature of up to 75°C, all the components are saturated with carbon dioxide gas, and the homogenization is carried out with feeding carbon dioxide gas, whereby the origination of peroxides is minimized and the reactogenicity is thus reduced. It is proposed to use PFOC emulsions as a means for treating air-and fat embolism, obliterating vascular injuries of extremities and poisoning with lipophilic poisons, as well as for preventing toxic injuries caused by various xenobiotics.

  一种用于血管内给药的具有气体传输特性的全氟有机化合物（PFOC）乳剂，由一种可从生物体内快速消除的全氟碳化合物和一种可从生物体内缓慢消除的全氟叔胺组成，还包括至少三种少量的全氟有机化合物混合物，这些混合物的结构和理化性质与主要成分接近，并构成一系列性质逐渐变化的全氟有机化合物。乳液中还含有少量的全氟烷烃外加剂。这种成分有助于在乳液颗粒内部形成更均匀、更稳定的非成团全氟碳化物相。全氟辛烷磺酸乳液由聚氧乙烯-聚氧丙烯共聚物稳定。该组合物的配方使乳液在储存和进入血流时保持稳定，并使全氟辛烷磺酸乳液的粘度较低，从而确保制剂具有较高的动态氧容量，提高向组织输送氧气的能力。 在制备乳剂时，将稳定剂在高达 75°C 的温度下加热，用二氧化碳气体使所有成分达到饱和，并用二氧化碳气体进行均质，从而最大限度地减少过氧化物的产生，降低反应性。 建议使用 PFOC 乳剂治疗空气和脂肪栓塞、四肢血管损伤和亲脂毒物中毒，以及预防各种异种生物造成的毒性损伤。
• The synthesis of highly fluorinated alkylcyclohexanes for use as oxygen carriers and the 19F and 13C NMR spectra of alkylcyclohexanes
  作者：Wen-Huey Lin、Richard J. Lagow

  DOI：10.1016/s0022-1139(00)85000-9

  日期：1990.12

  Perfluoroalkylcyclohexanes are promising candidates for oxygen carriers. The perfluoroalkylcyclohexane analogues and 1H-perfluoroalkylcyclohexanes of n-propylcyclohexane, i-propylcyclohexane, n-butylcyclohexane, s-butylcyclohexane, i-butylcyclohexane and t-butylcyclohexane were prepared and characterized. Their properties and NMR spectra are discussed.