| 1415567-70-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• CAS: 1415567-70-2
• 化学式: C₂₀H₄₂N₂O₄S₄Sn
• 分子量: 621.538
• InChiKey: JRNBBGCWAWNLHX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  甲氨基乙醛缩二甲醇 在 sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  Design, structural and spectroscopic elucidation, and the in vitro biological activities of new diorganotin dithiocarbamates

  摘要：

  The reaction of 2,2-dimethoxy-N-methylethyllamine or 2-methyl-1,3-dioxolane with CS2 in alkaline media produced two novel dithiocarbamate salts. Subsequent reactions with organotin halides yielded six new complexes: [SnMe2{S2CNR(R-1)(2)}(2)] (1), [Sn(n-Bu)(2){S2CNR(R-1)(2)}(2)] (2), [SnPh2{S2CNR(R-1)(2)}(2)] (3), [SnMe2{S2CNR(R-2)(2)}(2)] (4). [Sn(n-Bu)(2){S2CNR(R-2)(2)}(2)] (5), {SnPh2{S2CNR(R-2)(2)}(2)} (6). where R = methyl, R-1 = CH2CH(OMe)(2), and R-2 = 2-methyl-1,3-dioxolane. All compounds were identified in terms of infrared, H-1 and C-13 NMR, and the complexes were also characterized using Sn-119 NMR, Sn-119, Mossbauer and X-ray crystallography. The biological activity of all derivatives has been screened in terms of IC90 and IC50 against Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, Penicillium citrinum, Curvularia senegalensis, Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Streptococcus sanguinis, Escherichia coli, Citrobacter freundii, Salmonella typhimurium, and Pseudomonas aeruginosa and the results correlated well with a performed study of structure activity relationship (SAR). Complexes (3), (5) and (6) displayed the best IC90 and IC50 in the presence of the fungi, greater than that of miconazole, used as control drug. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.10.021