1,1,1-tris(pyridin-2-yl)methylamine | 207610-29-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1,1-tris(pyridin-2-yl)methylamine
• 英文别名: tris-(2-pyridyl)aminomethane；tris(2-pyridyl)methylamine；tpmaH；tpm；Tris(pyrid-2-yl)methylamine；tripyridin-2-ylmethanamine
• CAS: 207610-29-5
• 化学式: C₁₆H₁₄N₄
• 分子量: 262.314
• InChiKey: BOOZMUQOMHKQCS-UHFFFAOYSA-N

物化性质

• 熔点：
  98 °C
• 沸点：
  431.9±40.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯甲酸酐 、 1,1,1-tris(pyridin-2-yl)methylamine 以 二氯甲烷 为溶剂， 反应 24.0h， 以52%的产率得到N-[1,1,1-tris(pyridin-2-yl)methyl]benzamide
  参考文献：
  名称：

  [EN] NOVEL TECHNETIUM AND RHENIUM COMPLEXES, LIGANDS USED IN THEIR PREPARATION AND THEIR USE AS RADIOPHARMACEUTICALS
  [FR] NOUVEAUX COMPLEXES DE TECHNETIUM ET DE RHENIUM

  摘要：

  公开号：

  WO2006037988A3
• 作为产物：
  描述：

  2-氯吡啶 、 1,1-双(吡啶-2-基)甲胺 在 正丁基锂 作用下， 生成 1,1,1-tris(pyridin-2-yl)methylamine
  参考文献：
  名称：

  Studies of rheniumtricarbonyl complexes of tripodal pyridyl-based ligands

  摘要：

  The reaction of N-benzoyl and N-acetyl tris(pyridin-2-yl) methylamine 1b and 1c (LH = tpmbaH and tpmaaH) with [Re(CO)(5)Br] has been investigated and shown to proceed via the initial formation of a cationic rheniumtricarbonyl complex [(LH)Re(CO)(3)]Br in which coordination of the ligand occurs via the three pyridine rings. For tpmbaH 1b, but not tpmaaH 1c, this initial complex 2b readily undergoes the loss of HBr to give a neutral octahedral complex 4b [(L)Re(CO)(3)] where coordination occurs via two of the pyridine rings and the deprotonated amide nitrogen. The H-1 NMR spectrum of the latter complex 4b is very unusual in that at room temperature the signals for the 3-H protons on the coordinated pyridine rings are not visible due to extreme broadening of these resonances. Comparison with the analogous complex 7 from N-benzoyl bis(pyridin-2-yl) methylamine 6b (bpmbaH) confirms that this is due to rotation of the uncoordinated pyridine ring. The structure of the cationic complex 3d [(LH)Re(CO)(3)]Br formed from N-benzyl tris(pyridin-2-yl) methylamine 1d (bz-tpmaH) is also discussed. The crystal structures of complexes [(tpmba)Re(CO)(3)] 4b, [(bz-tpmaH)Re(CO)(3)]Br 3d and [(bpmba)Re(CO)(3)] 7 have been determined. In all complexes the coordination geometry around Re is distorted octahedral with a fac{Re(CO)(3)}(+) core. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.11.039

文献信息

• Nitritereduction by copper complexes
  作者：John G. Woollard-Shore、Jason P. Holland、Michael W. Jones、Jonathan R. Dilworth

  DOI：10.1039/b913463h

  日期：——

  nitrogen atoms, catalytic studies on the conversion of NO2− anions into NO and N2O gases revealed an excellent correlation between the initial rate of conversion and the experimental reduction potential as measured by cyclic voltammetry. Initial catalytic investigations reveal that these simple model complexes display a wide range of catalytic turnover rates, conversion yields and product gas compositions

  一系列 铜 已合成了配合物作为催化还原苯的潜在试剂。 亚硝酸盐阴离子。配体和相应的铜通过使用一系列技术（包括X射线晶体学，NMR，微分析，质谱，红外光谱，电化学研究和密度泛函理论计算）对复合物进行了表征。对于具有接合到赤道施主氮原子简单脂族取代基，对NO的转化催化研究复合物2 -阴离子成不N 2 O气体显示出初始转化率与通过循环伏安法测得的实验还原电位之间具有极好的相关性。初步的催化研究表明，这些简单的模型络合物显示出广泛的催化转化率，转化率和产物气体组成。总体而言，结果表明，需要进一步研究设计和使用铜 配合物作为亚硝酸盐还原催化剂是必要的。
• Copper complexes of the functionalised tripodal ligand tris(2-pyridyl)methylamine and its derivatives †
  作者：Phillip J. Arnold、Sian C. Davies、Jonathan R. Dilworth、Marcus C. Durrant、D. Vaughan Griffiths、David L. Hughes、Raymond L. Richards、Philip C. Sharpe

  DOI：10.1039/b008476j

  日期：——

  chemistry of the new tripodal ligand tris(2-pyridyl)methylamine (tpm) with copper(I), copper(II) and zinc(II) has been investigated. The synthesis of tpm can readily be modified to access a variety of related tripodal ligands such as 2-(methylsulfanyl)-1,1-di(2-pyridyl)ethylamine (mde); in addition, the primary amine function can be derivatised to extend further the range of complexes obtained. tpm itself

  新三脚架的配位化学 配体 三（2-吡啶基）甲胺（tPM）与铜（I），铜（II）和锌（II）的关系已被研究。tPM的合成可以很容易地修改以访问各种相关的三脚架配体 如 2-（甲基硫烷基）-1,1-二（2-吡啶基）乙胺（mde）; 另外，伯胺官能团可以被衍生化以进一步扩展所获得的络合物的范围。TPM本身是多功能的配体，显示了三种不同的协调模式：双齿（py，NH 2），三齿（2py，NH 2）和三齿（3py）。获得了化学计量比为Cu（tPM）n（n  = 1-3）的配合物。通过[Cu（tPM）2 ] [BF 4 ] 2 ·Me 2 CO的晶体结构说明了（2py，NH 2）配位模式，而在[Cu（SO 4）的晶体结构中发现了（3py）配位。）（tPM）（H 2 O）]·3H 2 O，[Cu（tPM）} 2 Br 3 ] Br·3MeOH以及锌络合物[Zn（tPM）（H 2 O）3] 2 [的Zn（H
• PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES
  申请人：BASF SE

  公开号：US20130116473A1

  公开（公告）日：2013-05-09

  The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(R a ) 3 , by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.

  本发明涉及制备氧基乙烯基异黄酮及其式I的O-保护衍生物，其中R为氢或OH保护基，例如Si（Ra）3基团。所述制备方法是通过将一般式II的化合物与氧化剂在至少一种过渡金属的存在下反应来实现的，其中R具有上述式I中给出的含义，即β-乙烯基异黄酮（式II，R=氢）或其O-保护衍生物（式II，R=OH保护基），所述氧化剂包括至少一种含氧化合物，所述氧化合物从过氧化氢和有机过氧化物中选择。
• Novel Technetium and Rhenium Complexes.
  申请人：Bhalla Rajiv

  公开号：US20080219921A1

  公开（公告）日：2008-09-11

  Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the us of 99m Tc radiopharmaceuticals of the invention for SPECT imaging.

  本发明提供了由三脚架配体组成的新型放射性锝和铼配合物。特别是，本发明提供了Tc(I)配合物。本发明还提供了适用于形成本发明的锝和铼配合物的新型配体，以及包括所述配合物的放射性药物组合物，其制备的工具包。本发明还涉及使用本发明的99mTc放射性药物进行SPECT成像。
• NOVEL TECHNETIUM AND RHENIUM COMPLEXES
  申请人：BHALLA RAJIV

  公开号：US20120077967A1

  公开（公告）日：2012-03-29

  Novel radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(I) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radiopharmaceutical compositions comprising said complexes, kits for their preparation. The invention also relates to the use of 99m Tc radiopharmaceuticals of the invention for SPECT imaging.

  本发明提供了包含三脚镧配体的新型放射性钼和铼配合物。特别地，本发明提供了Tc(I)配合物。本发明还提供了适用于形成本发明的钼和铼配合物的新型配体，以及包含所述配合物的放射性药物组合物，用于其制备的试剂盒。本发明还涉及使用本发明的99mTc放射性药物进行SPECT成像。