[5-(3-azidopropoxy)-2-nitrophenyl]methyl N-[(2S,3S,4S,6R)-3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]carbamate | 1596412-92-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 英文名称: [5-(3-azidopropoxy)-2-nitrophenyl]methyl N-[(2S,3S,4S,6R)-3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]carbamate
• CAS: 1596412-92-8
• 化学式: C₃₈H₃₉N₅O₁₆
• 分子量: 821.752
• InChiKey: BBYUNLUTLHRBPS-WJHCCKJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  59
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  288
• 氢给体数：
  6
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  5-羟基-2-硝基苯甲醛 在 甲醇 、 sodium tetrahydroborate 、 sodium azide 、 potassium carbonate 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.5h， 生成 [5-(3-azidopropoxy)-2-nitrophenyl]methyl N-[(2S,3S,4S,6R)-3-hydroxy-2-methyl-6-[[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]oxan-4-yl]carbamate
  参考文献：
  名称：

  DRUG DELIVERY POLYMER AND USES THEREOF

  摘要：

  本文描述了基于铂的刷状臂星形聚合物（Pt-BASPs），或其药物组合物，用于传递基于铂的药剂，如顺铂。还提供了涉及Pt-BASPs，或其药物组合物，用于治疗增殖性疾病如癌症（例如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、肝癌、肾癌或前列腺癌）的方法和试剂盒。

  公开号：

  US20140308234A1

文献信息

• A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
  作者：Longyan Liao、Jenny Liu、Erik C. Dreaden、Stephen W. Morton、Kevin E. Shopsowitz、Paula T. Hammond、Jeremiah A. Johnson

  DOI：10.1021/ja502011g

  日期：2014.4.23

  The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.
• US9381253B2
  申请人：——

  公开号：US9381253B2

  公开（公告）日：2016-07-05
• [EN] DRUG DELIVERY POLYMER AND USES THEREOF<br/>[FR] POLYMÈRE D'ADMINISTRATION DE MÉDICAMENT ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014169073A1

  公开（公告）日：2014-10-16

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.