阿克那霉素B | 57596-79-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 中文名称: 阿克那霉素B
• 英文名称: Aclacinomycin B
• 英文别名: methyl (1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[[(1R,3R,5S,8S,10S,12S,14S)-5,14-dimethyl-6-oxo-2,4,9,13-tetraoxatricyclo[8.4.0.03,8]tetradecan-12-yl]oxy]-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate
• CAS: 57596-79-9
• 化学式: C₄₂H₅₁NO₁₅
• 分子量: 809.8
• InChiKey: RQHZAASWYUEYCJ-NFJBMJLVSA-N

物化性质

• 熔点：
  163-167° (dec)
• 比旋光度：
  D24 +3° (c = 1 in methylene chloride)
• 沸点：
  873.0±65.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  58
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  206
• 氢给体数：
  3
• 氢受体数：
  16

文献信息

• Rhodomycin-group of antibiotics and process for preparing same
  申请人：SANRAKU-OCEAN CO., LTD.

  公开号：EP0022574A1

  公开（公告）日：1981-01-21

  New anthracycline glycoside derivatives RDC havinc botent anticancer activities and lower toxicities and a process for the production thereof by microbiological Glycosidation of ε-rhodomycinone ε-isorhodomycinone β-rhodomycinone τ-rhodomycinone β-pyrromycinone using Streptomyces Galilaeus having the general formula I: wherein a substitution of R1, R2, R3 and R4 represents a ,carbomethoxy or hydroxyl group, ,hydroxyl hydroxyl group, and a hydrogen atom, respectively. group and hydroxyl group, or hydroxyl group, carbomethoxy group and hydroxyl group,

  新的蒽环类糖苷衍生物 RDC havinc botent anticancer activities and lower toxicities and a process for production thereof by microbiological Glycosidation of ε-rhodomycinone ε-isorhodomycinone β-rhodomycinone τ-rhodomycinone β-pyrromycinone using Streptomyces Galilaeus having general formula I: 其中 R1、R2、R3 和 R4 的取代基分别代表羰基或羟基、羟基羟基和氢原子、
• Process for anthracycline glycosides
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0050724A1

  公开（公告）日：1982-05-05

  Anthracycline glycosides A, e.g. aclacinomycin A, is obtained from anthracycline glycosides B by microbial degradation with Streptomyces galileus or S. melanogenes sp.

  蒽环类苷 A（如阿克拉霉素 A）是由蒽环类苷 B 通过加利莱链霉菌（Streptomyces galileus）或美拉菌（S. melanogenes sp.
• Process for aclacinomycins and microorganism used therein
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0050725A1

  公开（公告）日：1982-05-05

  Production of aclacinomycins A and B by means of Streptomyces galilaeus ATCC 31615.

  利用加利莱氏链霉菌（Streptomyces galilaeus ATCC 31615）生产阿克拉霉素 A 和 B。
• Anthracycline antibiotics and their preparation method
  申请人：SANRAKU-OCEAN CO., LTD.

  公开号：EP0072974A1

  公开（公告）日：1983-03-02

  Anthracycline compounds, 2-hydroxyaclacinomycin B having potent antitumor activity and low toxicity, of formula wherein for 2-hydroxyaclacinomycin A; for 2-hydroxyaclacinomycin B; and for 2-hydroxyaclacinomycin N; and a process for producing 2-hydroxyaclacinomycins A, B, and N by by fermentation of a strain of N Streptomyces galilaeus A-862 (FERM BP-45).

  具有强效抗肿瘤活性和低毒性的蒽环类化合物、2-羟基青霉霉素 B，其式为 2-羟基青霉霉素 A、2-羟基青霉霉素 B 和 2-羟基青霉霉素 N；以及通过 N Streptomyces galilaeus A-862 菌株发酵生产 2-羟基青霉霉素 A、B 和 N 的工艺（FERM BP-45）。
• Process for optically active anthracycline glycosides, the novel 4-deoxy-aclacinomycins A and B and pharmaceutical preparations
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0083019A2

  公开（公告）日：1983-07-06

  Racemic anthracyclinones are stereoselectively glycosidated with the aid of Streptomyces glailaeus OBB-111-848 (ATCC 31598). The process also affords novel antibiotic anthracycline glycosides.

  外消旋蒽环类化合物在釉链霉菌 OBB-111-848 （ATCC 31598）的帮助下进行了立体选择性糖苷化。 该过程还产生了新型抗生素蒽环类糖苷。