盐酸加柔比星 | 140637-82-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 蒽环类药物
• 中文名称: 盐酸加柔比星
• 英文名称: [2-[(2S,4S)-4-[(2R,3R,4R,5S,6S)-3-fluoro-4,5-dihydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-oxoethyl] 3-aminopropanoate;hydron;chloride
• CAS: 140637-82-7
• 化学式: C30H33ClFNO13
• 分子量: 670.0
• InChiKey: PISPJMVXLMWWNB-ZZBYHBTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  46
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  232
• 氢给体数：
  7
• 氢受体数：
  15

文献信息

• POLYNUCLEOTIDES ENCODING NOVEL HUMAN PHOSPHATASES
  申请人：Jackson G. Donald

  公开号：US20050130286A1

  公开（公告）日：2005-06-16

  The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

  本发明提供了编码人类磷酸酶多肽、片段及其同源物的新型多核苷酸。还提供了载体、宿主细胞、抗体以及生产上述多肽的重组和合成方法。本发明进一步涉及将这些新型人类磷酸酶多肽应用于诊断、治疗和/或预防与这些多肽有关的各种疾病和/或失调，特别是心血管疾病和/或失调的诊断和治疗方法。本发明进一步涉及鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
• Human phosphatase RET31, and variants thereof
  申请人：Jackson G. Donald

  公开号：US20060014180A1

  公开（公告）日：2006-01-19

  The present invention provides novel polynucleotides encoding human phosphatase polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel human phosphatase polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly cardiovascular diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

  本发明提供了编码人类磷酸酶多肽、片段及其同源物的新型多核苷酸。还提供了载体、宿主细胞、抗体以及生产上述多肽的重组和合成方法。本发明进一步涉及将这些新型人类磷酸酶多肽应用于诊断、治疗和/或预防与这些多肽有关的各种疾病和/或失调，特别是心血管疾病和/或失调的诊断和治疗方法。本发明进一步涉及鉴定本发明多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
• Method of using a cox-2 inhibitor and a topoisomerase II inhibitor as a combination therapy in the treatment of neoplasia
  申请人：Masferrer L Jaime

  公开号：US20060105961A1

  公开（公告）日：2006-05-18

  The present invention provides compositions and methods to treat, prevent or inhibit a neoplasia or a neoplasia-related disorder in a mammal using a combination of a COX-2 inhibitor and a topoisomerase II inhibitor.

  本发明提供了使用 COX-2 抑制剂和拓扑异构酶 II 抑制剂组合治疗、预防或抑制哺乳动物肿瘤或肿瘤相关疾病的组合物和方法。
• US7153678B2
  申请人：——

  公开号：US7153678B2

  公开（公告）日：2006-12-26
• US7358074B2
  申请人：——

  公开号：US7358074B2

  公开（公告）日：2008-04-15