2-ethoxyvinylphosphonyl dichloride | 7010-16-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2-ethoxyvinylphosphonyl dichloride
• 英文别名: 2-ethoxyvinylphosphonic acid dichloroanhydride；(2-ethoxyvinyl)phosphonic dichloride；Phosphonic dichloride, (2-ethoxyethenyl)-；1-dichlorophosphoryl-2-ethoxyethene
• CAS: 7010-16-4
• 化学式: C₄H₇Cl₂O₂P
• 分子量: 188.978
• InChiKey: MIQZGJIOIQXKQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethoxyvinylphosphonyl dichloride 在 氯 作用下， 生成 (1-chloro-2-ethoxy-vinyl)-phosphonic acid dichloride
  参考文献：
  名称：

  Ismailov,V.M. et al., Journal of general chemistry of the USSR, 1973, vol. 43, p. 1004 - 1006

  摘要：

  DOI：
• 作为产物：
  描述：

  trichloro(β-ethoxyvinyl)phosphonium hexachlorophosphorate 在 sodium acetate 作用下， 以 苯 为溶剂， 生成 2-ethoxyvinylphosphonyl dichloride
  参考文献：
  名称：

  Mitrasov, Yu. N.; Kormachev, V. V., Journal of general chemistry of the USSR, 1983, vol. 53, # 7, p. 1507 - 1508

  摘要：

  DOI：

文献信息

• Synthesis of New Diaryl(hetaryl)ethylphosphonic Acids
  作者：Yu. M. Sadykova、A. V. Zalaltdinova、А. K. Smailov、А. R. Burilov、М. А. Pudovik

  DOI：10.1134/s1070363221070215

  日期：2021.7

  Abstract An original, new method for the synthesis of previously unknown diaryl(hetaryl)ethylphosphonic acids containing pharmacophoric fragments was developed as a result of the acid-catalyzed reaction of (2-ethoxyvinyl)phosphonic dichloride with heterocyclic compounds such as 4-hydroxy-6-methyl-2-pyrone, 4-hydroxycoumarin, and also thymol and carvacrol containing a hydroxyl group. Composition and

  摘要 由于（2-乙氧基乙烯基）膦酰二氯化物与杂环化合物（如 4-羟基-6-甲基-2-吡喃酮、4-羟基香豆素，以及含有羟基的百里酚和香芹酚。所有二芳基（杂芳基）乙基膦酸的组成和结构均根据1 H、13 C 和31 P NMR、IR 光谱、质谱和元素分析数据确定。
• New P-Containing Linear and Macrocyclic Polyphenols
  作者：Alexander R. Burilov、Irina R. Knyazeva、Elmira M. Kasymova、Yulia M. Sadykova、Michael A. Pudovik、Wolf D. Habicher、Oleg G. Sinyashin

  DOI：10.1080/10426507.2010.537289

  日期：2011.3.31

  Abstract We synthesized new phosphorus-containing linear and macrocyclic polyphenols using organic compounds containing phosphorus-carbon bonds and the phosphorus atom of various coordination, and also with reactive acetal, aldehyde, vinylethoxy, and methylene quinone fragments as starting materials. These achievements are briefly summarized.

  摘要 我们以含有磷碳键和各种配位磷原子的有机化合物为原料，以反应活性的缩醛、醛、乙烯基乙氧基和亚甲基醌片段为原料，合成了新型含磷线性和大环多酚。简要总结了这些成就。
• Synthesis of calix[4]resorcinarenes, containing phosphoryl fragments at the lower rim of the molecule
  作者：A. R. Burilov、I. R. Knyazeva、Yu. M. Sadykova、M. A. Pudovik、W. D. Habicher、I. Baier、A. I. Konovalov

  DOI：10.1007/s11172-007-0173-2

  日期：2007.6

  Reaction of resorcinol with phosphorylated acetals or ethoxyvinylphosphonic acid esters in acidic media leads to calix[4]resorcinarenes, containing dialkoxyphosphoryl fragments at the lower rim of the molecule. When the alkyl substituent in alkoxy groups at phosphorus atom is not very long, a partial hydrolysis of the initially formed products takes place to give calixarenes with alkoxyhydroxyphosphoryl fragments.

  间苯二酚与磷酸化乙醛或乙氧基乙烯基膦酸酯在酸性介质中发生反应，生成钙[4]间苯二酚，分子下缘含有二烷氧基磷酰片段。当磷原子上的烷氧基中的烷基取代基不很长时，最初形成的产物会发生部分水解，生成含有烷氧基羟基磷酰片段的钙[4]间苯二酚。
• Some Transformations of Mono-and Dichloro(diethoxyphosphoryl)acetaldehydes
  作者：V. M. Ismailov、G. E. Allakhverdieva、N. D. Sadykhova、I. A. Mamedov、N. N. Yusubov

  DOI：10.1134/s1070363220010132

  日期：2020.1

  Addition of ethanol and diethyl phosphonate to the carbonyl group of 2,2-dichloro-2-(diethoxyphosphoryl)-acetaldehyde has been studied, and the corresponding α-chloro ether, acetal, and phosphorylated metrifonate have been obtained. α,α-Dichloro-α-phosphoryl carbonyl compounds have been found to undergo haloform cleavage by the action of bases. Perkow reaction of mono- and dichloro(diethoxyphosphoryl)acetaldehydes

  已经研究了将乙醇和膦酸二乙酯加到2，2-二氯-2-（二乙氧基磷酰基）-乙醛的羰基上，并获得了相应的α-氯醚，乙缩醛和磷酸化的甲磺酸酯。已经发现α，α-二氯-α-磷酰基羰基化合物在碱的作用下进行卤仿裂解。一氯和二氯（二乙氧基磷酰基）乙醛与亚磷酸三乙酯的perkow反应，得到2-乙基（二乙氧基磷酰基）乙烯基磷酸二乙酯。
• Novel 4-chloro-or-4-bromoresorcinol-based bicyclic phosphonates
  作者：Yulia M. Sadykova、Larisa M. Sadikova、Alena V. Zalaltdinova、Yulia K. Voronina、Alexander R. Burilov、Michael A. Pudovik、Jean-Luc Pirat

  DOI：10.1080/10426507.2018.1491849

  日期：2018.11.2

  with 2-ethoxyvinylphosphonic acid dichloroanhydride has been investigated for the first time. It has been determined that the product of the reaction is the mixture of structural isomers of bicyclic phosphonates at the ratio of 9:1. The structure and composition of the compounds have been elucidated from 1H, 31P, and 13C NMR spectroscopy, mass-spectrometry (MALDI-TOF), as well as elemental and X-ray

  摘要 首次研究了4-氯-和4-溴苯二酚与2-乙氧基乙烯基膦酸二氯酸酐的反应。已经确定反应产物是比例为9:1的双环膦酸酯的结构异构体的混合物。化合物的结构和组成已从 1H、31P 和 13C NMR 光谱、质谱 (MALDI-TOF) 以及元素和 X 射线分析阐明。图形概要