(R)-2-氨基庚烷盐酸盐 | 101689-06-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (R)-2-氨基庚烷盐酸盐
• 英文名称: (R)-2-heptylamine hydrochloride
• 英文别名: (R)-2-aminoheptane hydrochloride；Tuaminoheptane hydrochloride, (R)-；(2R)-heptan-2-amine;hydrochloride
• CAS: 101689-06-9
• 化学式: C₇H₁₇N*ClH
• 分子量: 151.68
• InChiKey: JOPQZCZKKFHRNT-OGFXRTJISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.34
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲氧基-三氟甲基苯 、 (R)-2-氨基庚烷盐酸盐 在 pyridine 作用下， 以 吡啶 、 四氯化碳 为溶剂， 生成 (R)-3,3,3-Trifluoro-2-methoxy-N-((R)-1-methyl-hexyl)-2-phenyl-propionamide
  参考文献：
  名称：

  Braconnier, M.F.; Braekman, J.C.; Daloze, D., Bulletin des Societes Chimiques Belges, 1985, vol. 94, # 8, p. 605 - 614

  摘要：

  DOI：
• 作为产物：
  描述：

  异庚胺 在 盐酸 、 Candida antarctica (Novozym 435) 作用下， 以 乙醚 为溶剂， 反应 69.0h， 生成 (R)-2-氨基庚烷盐酸盐
  参考文献：
  名称：

  RESOLUTION OF CHIRAL ALIPHATIC AND ARYLALKYL AMINES USING IMMOBILIZEDCANDIDA ANTARCTICALIPASE AND ISOLATION OF THEIR R- AND S-ENANTIOMERS

  摘要：

  The resolution of chiral aliphatic and arylalkyl amines in high enantiomeric excess (up to 97.5% ee for the R-enantiomers and up to 99.9% ee for the S-enantiomers) and good yield (50-80%) using immobilized Candida antarctica lipase and ethyl acetate as acyl donor has been demonstrated. A second resolution on the R-amine increased the enantiomeric excess to more than 99.5% (up to 99.9%).

  DOI：

  10.1081/scc-100000584

文献信息

• Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines
  作者：Alexander L. Reznichenko、Hiep N. Nguyen、Kai C. Hultzsch

  DOI：10.1002/anie.201004570

  日期：2010.11.15

  A hard nut to crack: The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare‐earth‐metal catalysts with up to 61 % ee and 73 % de in the case where R2 contains a stereogenic center.

  难以破解的难题：在R 2包含立体中心的情况下，可以使用双萘甲酸酯稀土金属催化剂（ee高达61％ee和de高达73％） 将简单的胺不对称分子间Markovnikov加成到未活化的烯烃上 。
• Medicated plasters
  申请人：NITTO DENKO CORPORATION

  公开号：EP0387751A2

  公开（公告）日：1990-09-19

  Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or higher and contains one of the following three components: (i) a basic physiologically active agent and an acidic substance, (ii) a salt of a basic physiologically active agent and a basic substance, and (iii) a basic physiolosically active agent and a salt of a basic physiolosically active agent.

  药用膏药，由柔性支架和层压在其上的压敏胶层组成，其中所述压敏胶层的外露表面 pH 值为 7 或更高，并含有以下三种成分之一： (i) 碱性生理活性剂和酸性物质、 (ii) 碱性生理活性剂和碱性物质的盐，以及 (iii) 碱性生理活性剂和碱性生理活性剂的盐。
• Braconnier, M.F.; Braekman, J.C.; Daloze, D., Bulletin des Societes Chimiques Belges, 1985, vol. 94, # 8, p. 605 - 614
  作者：Braconnier, M.F.、Braekman, J.C.、Daloze, D.

  DOI：——

  日期：——
• RESOLUTION OF CHIRAL ALIPHATIC AND ARYLALKYL AMINES USING IMMOBILIZED<i>CANDIDA ANTARCTICA</i>LIPASE AND ISOLATION OF THEIR R- AND S-ENANTIOMERS
  作者：Bruce A. Davis、David A. Durden

  DOI：10.1081/scc-100000584

  日期：2001.1

  The resolution of chiral aliphatic and arylalkyl amines in high enantiomeric excess (up to 97.5% ee for the R-enantiomers and up to 99.9% ee for the S-enantiomers) and good yield (50-80%) using immobilized Candida antarctica lipase and ethyl acetate as acyl donor has been demonstrated. A second resolution on the R-amine increased the enantiomeric excess to more than 99.5% (up to 99.9%).