2-amino-6-(3-butylureido)-4-(piperidin-1-yl)pyrimidine 1-oxide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-6-(3-butylureido)-4-(piperidin-1-yl)pyrimidine 1-oxide
• 化学式: C₁₄H₂₄N₆O₂
• 分子量: 308.384
• InChiKey: KTBLWQMXNNJJDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  110.22
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  米诺地尔 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 生成 2-amino-6-(3-butylureido)-4-(piperidin-1-yl)pyrimidine 1-oxide
  参考文献：
  名称：

  Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents

  摘要：

  Activation of minoxidil (MNX) with N,N'-carbonyldiimidazole and coupling with natural polyamines (PAs) and commercially available aliphatic or aromatic amines provided a series of new conjugates which were evaluated for their ability to induce differentiation to HL-60 acute myeloid leukemia cancer cells, using a modified NBTZ reduction test. Although neither MNX nor 4,4'-methylenedianiline (MDA) or 2,7-diaminofluorene (DAF), alone or in combination, had any effect, the MNX-spermine (SPM) conjugate (11) and the conjugates 7 and 8 of MNX with MDA and DAF exhibited a differentiation-inducing effect at a concentration of 10 mu M without being toxic on proliferating human peripheral blood mononuclear cells. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2016.01.048

文献信息

• US4945093A
  申请人：——

  公开号：US4945093A

  公开（公告）日：1990-07-31
• US5034387A
  申请人：——

  公开号：US5034387A

  公开（公告）日：1991-07-23
• Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents
  作者：Sonia Stoica、George E. Magoulas、Antonia I. Antoniou、Sherif Suleiman、Analisse Cassar、Lucienne Gatt、Dionissios Papaioannou、Constantinos M. Athanassopoulos、Pierre Schembri-Wismayer

  DOI：10.1016/j.bmcl.2016.01.048

  日期：2016.2

  Activation of minoxidil (MNX) with N,N'-carbonyldiimidazole and coupling with natural polyamines (PAs) and commercially available aliphatic or aromatic amines provided a series of new conjugates which were evaluated for their ability to induce differentiation to HL-60 acute myeloid leukemia cancer cells, using a modified NBTZ reduction test. Although neither MNX nor 4,4'-methylenedianiline (MDA) or 2,7-diaminofluorene (DAF), alone or in combination, had any effect, the MNX-spermine (SPM) conjugate (11) and the conjugates 7 and 8 of MNX with MDA and DAF exhibited a differentiation-inducing effect at a concentration of 10 mu M without being toxic on proliferating human peripheral blood mononuclear cells. (C) 2016 Elsevier Ltd. All rights reserved.