申请人:Kyowa Hakko Kogyo Co., Ltd.
公开号:US05128369A1
公开(公告)日:1992-07-07
Disclosed is a novel arylalkylamine derivative represented by the formula (I) ##STR1## wherein X represents --O--, --CH.sub.2 -- or --NR.sup.3 -- in which R.sup.3 represents hydrogen or lower alkyl; Y represents --NH-- or ##STR2## Z represents ##STR3## in which R.sup.4 represents hydrogen or lower alkyl or ##STR4## Q represents an optionally substituted aryl or optionally substituted aromatic heterocyclic group; each of R.sup.1 and R.sup.2 independently represents hydrogen or lower alkyl; each of m and n independently represents an integer of 0 or 1; and a pharmaceutically acceptable salt thereof. The compound (I) and a pharmaceutically acceptable salt thereof show bronchodilatory and antiallergic activities, and are useful for treating respiratory disorders such as bronchial asthma.
本发明涉及一种新颖的芳基烷基胺衍生物,其表示为公式(I)##STR1##其中X表示--O--,--CH.sub.2--或--NR.sup.3--,其中R.sup.3表示氢或低碳基;Y表示--NH--或##STR2##Z表示##STR3##其中R.sup.4表示氢或低碳基或##STR4##Q表示可选取代的芳基或可选取代的芳香杂环基;R.sup.1和R.sup.2各自独立地表示氢或低碳基;m和n各自独立地表示0或1的整数;以及其药学上可接受的盐。化合物(I)及其药学上可接受的盐表现出支气管扩张和抗过敏活性,并且对于治疗支气管哮喘等呼吸系统疾病非常有用。