fac-[RuH(1,5-cod)(NH₂NMe₂)₃](PF₆) | 61042-65-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: fac-[RuH(1,5-cod)(NH₂NMe₂)₃](PF₆)
• 英文别名: {(η4-cycloocta-1,5-diene)RuH(NH2NMe2)3}PF6；(cyclo-octa-1,5-diene)tris(N',N'-dimethylhydrazine)hydridorutheniumhexafluorophosphate；(η4-C8H12)RuH(NH2NMe2)3PF6；(1Z,5Z)-cycloocta-1,5-diene;1,1-dimethylhydrazine;ruthenium(1+) monohydride;hexafluorophosphate
• CAS: 61042-65-7
• 化学式: C₁₄H₃₇N₆Ru*F₆P
• 分子量: 535.522
• InChiKey: CGAYOABRCWSGLY-IVCCQKQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  fac-[RuH(1,5-cod)(NH₂NMe₂)₃](PF₆) 在 lithium chloride 作用下， 以 甲醇 为溶剂， 生成 [(RuClH(cyclo-octa-1,5-diene))2NH2NMe2]
  参考文献：
  名称：

  阳离子钌（II）系统。第1部分。二烯（肼）钌（II）阳离子的制备，反应性以及氨基键合complex配合物的形成

  摘要：

  聚合物质[{RuCl 2（diene）} n ]（1; n > 2）和适当的肼已用于制备盐[Ru（diene）（N 2 H 4）4 ] [BPh 4 ] 2 { 2; 二烯=双环[2.2.1]庚-2,5-二烯（nbd）或环辛-1,5-二烯（cod）} [Ru（cod）（NH 2 NHMe）4 ] [PF 6 ] 2， [RuH（cod）（NH 2 NRR'）3 ] X [R = R'= Me，X = BPh 4（3）或X = PF 6（4）; R = H，R'= H或Me，X = BPh 4（5）]。（2;二烯=鳕鱼）在回流的丙酮-乙醇混合物中的溶液给出化学计量的复合物[Ru（BPh 4）（cod）]（6），并且在存在配体L的情况下，[Ru（cod）L 4 ] [BPh 4 ] 2 [L =吡啶（py），Me 2 SO（dmso）或MeCN]，[RuL 6 ] [BPh 4 ] 2（L =

  DOI：

  10.1039/dt9770001809
• 作为产物：
  描述：

  偏二甲肼 、 dichloro(1,5-cyclooctadiene)ruthenium(II) 、 ammonium hexafluorophosphate 以 甲醇 、 水 为溶剂， 反应 13.75h， 以4.9 g的产率得到fac-[RuH(1,5-cod)(NH₂NMe₂)₃](PF₆)
  参考文献：
  名称：

  [EN] HDAC6 INHIBITORS AND IMAGING AGENTS
  [FR] INHIBITEURS DE HDAC6 ET AGENTS D'IMAGERIE

  摘要：

  本文提供了一些有用的化合物，用于结合一个或多个组蛋白去乙酰化酶（HDACs）。本申请进一步提供了用作HDAC位置发射断层扫描成像的放射标记化合物。还提供了制备未标记和标记化合物的方法，诊断方法，以及治疗与HDAC相关疾病的方法。

  公开号：

  WO2018191360A1

文献信息

• Chiral Mono- and Bis-annelated Cyclopentadienyl Ligands Derived from Tartaric Acid:  Synthesis of [(η⁵-Cyclopentadienyl)RuCl(cod)] and [(η⁵-Cyclopentadienyl)(η⁶-benzene)Ru]PF₆ Derivatives
  作者：Gerard P. McGlacken、Ciara T. O'Brien、Adrian C. Whitwood、Ian J. S. Fairlamb

  DOI：10.1021/om700393b

  日期：2007.7.1

  The synthesis of chiral mono- and bis-annelated 1,3-cyclopentadienes derived from tartaric acid, a chiral pool starting material, is described. In addition to known functionalized chiral 1,3-cyclopentadienes, new derivatives have also been structurally characterized by X-ray crystallographic and NMR spectroscopic studies. Neutral and cationic ruthenium(II) complexes, containing a mono-annelated chiral

  描述了衍生自酒石酸（一种手性池起始材料）的手性单和双退火的1，3-环戊二烯的合成。除已知的官能化手性1,3-环戊二烯外，新衍生物还通过X射线晶体学和NMR光谱研究进行了结构表征。已经成功制备了含有单退火手性环戊二烯基配体（1）的中性和阳离子钌（II）配合物。的X射线晶体结构[（η 5 -Cp '）的Ru（η 6 -苯）] [PF 6 ]中，Cp'= 1，已被确定。
• Formation of a homoleptic unbridged metal–metal bonded isocyanide dimer of ruthenium(<scp>I</scp>) by metal–carbon bond cleavage in [Ru(1–2,5-η-C₈H₁₃)(CN-xylyl)₄]PF₆: the X-ray structure determination of [Ru₂(CN-xylyl)₁₀][BPh₄]₂
  作者：Anthony A. Chalmers、David C. Liles、Elsie Meintjies、Hester E. Oosthuizen、Jan A. Pretorius、Eric Singleton

  DOI：10.1039/c39850001340

  日期：——

  Refluxing [Ru(1–2,5-η-C8H13)(CN-xylyl)4]PF6 in [2H6]acetone gives C8H13D and [Ru2(CN-xylyl)10][PF6]2; an X-ray structure determination of [Ru2(CN-xylyl)10][BPh4]2 shows the cation to be an unbridged, metal–metal bonded dimer of ruthenium(I) containing eclipsed 2,6-dimethylphenyl isocyanide ligands.

  回流的[Ru（1-2.5-η-C 8 H ^ 13）（CN二甲苯基）4 ] PF 6中[ 2 ħ 6 ]丙酮给出了C语言8 ħ 13 d和的[Ru 2（CN二甲苯基）10 ] [PF 6 ] 2；[Ru 2（CN-二甲苯基）10 ] [BPh 4 ] 2的X射线结构测定表明，该阳离子为钌（I）的未桥接，金属与金属键合的二聚体，其中含有黯淡的2,6-二甲基苯基异氰化物配体。
• Cationic ruthenium systems. Part 2. Synthesis, characterization, and X-ray structure of hydridopentakis(dimethylphenylphosphine)-ruthenium(II) hexafluorophosphate: a discussion of the effects of steric strains on the reactivity of the complex
  作者：Terence V. Ashworth、Magriet J. Nolte、Eric Singleton、Michael Laing

  DOI：10.1039/dt9770001816

  日期：——

  The complex [RuH(PMe2Ph)5][PF6] has been prepared by treatment of a methanolic solution of [RuH(cod)(NH2-NMe2)3][PF6](cod = cyclo-ocata-1,5-diene) with PMe2Ph under argon and has been characterized by microanalytical, i.r., and 1H n.m.r. data and by a three-dimensional X-ray structure determination. The colourless crystals of [RuH(PMe2Ph)5][PF6], M= 938, are orthorhombic, space group P212121, a= 21

  络合物[期RuH（PME 2 PH）5 ] [PF 6 ]已编制处理的甲醇溶液[期RuH（COD）（NH 2 -NMe 2）3 ] [PF 6 ]（COD =环ocata- 1,5-二烯）与PMe 2 Ph在氩气下，通过显微分析，红外光谱和1 H nmr数据以及三维X射线结构测定来表征。的[期RuH（PME的无色晶体2 PH）5 ] [PF 6 ]，中号= 938，是斜方晶系，空间群P 2 1 2 1 21，一个= 21.55（3）， b = 19.08（3）， C ^ = 10.38（2）埃， û = 4 269埃3， d米= 1.48， d Ç =1.46克厘米-3， Ž = 4。结构已经解决由heavyatom方法和通过最小二乘精制， - [R 0.061使用石墨单色化钼收集在衍射仪1层954观察到的反射ķ α辐射。关于钌的配合是扭曲的八面体。与膦反式键的键长氢化物配体（Ru–P 2
• Ashworth, Terence V.; Chalmers, Anthony A.; Liles, David C., Organometallics, 1987, vol. 6, # 7, p. 1543 - 1552
  作者：Ashworth, Terence V.、Chalmers, Anthony A.、Liles, David C.、Meintjies, Elsie、Singleton, Eric

  DOI：——

  日期：——
• The dominant steric effect in the synthesis of ammine hydrido- and chlorido-Ru(II)- N , N -dimethylhydrazine and mixed alkyl–aryl phosphine complexes: Novel methyldiazene reduction intermediates
  作者：Frederick P. Malan、Afsar Ali、Eric Singleton、Reinout Meijboom

  DOI：10.1016/j.ica.2015.08.019

  日期：2015.10

  Novel cationic hydrido complexes [RuH(1,5-cod)(NH3)(NH2NMe2)(2)](X) (X = PF6, BPh4) and chloridoammine complexes [RuCl(1,5-cod)(NH3)(2)(NH2NMe2)](X) (X = PF6, BPh4), were isolated from the reaction of the polymeric [RuCl2(1,5-cod)](x) with NH2NMe2. Reaction of the hydrido complexes with the phosphine ligands PMe3, PMe2Ph, P(OMe)(2)Ph resulted in the formation of monohydrido-phosphine complexes, whereas reaction with the bulkier PMePh2 ligand gave dihydrido-phosphine complexes. Similar reactions of the chlorido-ammine complexes with the phosphine ligands PMe3, PMe2Ph, P(OMe)(2)Ph, and PMePh2 all sequentially substituted the NH2NMe2 and the 1,5-cod ligands to give the chlorido-ammine phosphine complexes. All complexes were fully characterised and the single crystal X-ray structures were determined for [RuHP(OMe)(2)Ph}(5)](BPh4), [RuH2(PMePh2)(4)], [Ru(PMe2Ph)(3)}(2)(mu-F)(3)](PF6), fac-[RuCl (NH3) (2)(PMe2Ph)(3)](PF6), and [RuCl(NH3)(PMe2Ph)(4)](PF6). Intramolecular strain between coordinated sigma-donor ligands in the Ru(II)-NH2NMe2 precursor complexes as well as the relative steric bulk of incoming r-donor ligands were found to be chemically directing in the formation of monohydrido-, bishydrido, mono-ammine, and bis-ammine ruthenium(II) complexes. (C) 2015 Elsevier B.V. All rights reserved.