1-[5-(1-benzylindazol-3-yl)furan-2-yl]-N-methylmethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-[5-(1-benzylindazol-3-yl)furan-2-yl]-N-methylmethanamine
• 化学式: C₂₀H₁₉N₃O
• 分子量: 317.39
• InChiKey: WYZYPYOMWUQPAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  43
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(5-羟基甲基-2-呋喃基)-1-苯基吲哚 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 1-[5-(1-benzylindazol-3-yl)furan-2-yl]-N-methylmethanamine
  参考文献：
  名称：

  1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis

  摘要：

  Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)-indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.

  DOI：

  10.1021/jm020070b

文献信息

• Method of treating sepsis
  申请人：Yung Shin Pharmaceutical Ind. Co., Ltd.

  公开号：EP1331223B1

  公开（公告）日：2008-02-13
• 1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis
  作者：Jin-Cherng Lien、Fang-Yu Lee、Li-Jiau Huang、Shiow-Lin Pan、Jih-Hwa Guh、Che-Ming Teng、Sheng-Chu Kuo

  DOI：10.1021/jm020070b

  日期：2002.11.1

  Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)-indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.