2-(2-氯吩噻嗪-10-基)-N,N-二甲基乙胺盐酸盐 | 2095-24-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 2-(2-氯吩噻嗪-10-基)-N,N-二甲基乙胺盐酸盐
• 英文名称: chlorfenethazine
• 英文别名: Chlorphenethazine；2-(2-chlorophenothiazin-10-yl)-N,N-dimethylethanamine
• CAS: 2095-24-1
• 化学式: C₁₆H₁₇ClN₂S
• 分子量: 304.843
• InChiKey: ILROKGAXBGPFAI-UHFFFAOYSA-N

物化性质

• 密度：
  1.1899 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  31.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 铜 作用下， 生成 2-(2-氯吩噻嗪-10-基)-N,N-二甲基乙胺盐酸盐
  参考文献：
  名称：

  DE1011887

  摘要：

  公开号：

文献信息

• A method of sensitizing multidrug resistant cells to antitumor agents
  申请人：YALE UNIVERSITY

  公开号：EP0361485A2

  公开（公告）日：1990-04-04

  A method for sensitizing multidrug resistant cells to antitumor agents comprising contacting multidrug resistant cells, with an effective amount of a compound of the formula wherein n is 1, 2 or 3, X is CF₃, -O-CH₃, Br, I, Cl, H, W and S-CH₃ and R¹ and R², independently of each other are -CH₃-CH₂-CH₃, CH₂CH₂OHCH₂OH, or NR¹ R² form a ring wherein R³ is -CH₃, CH₂-CH₃,-H, CH₂OH and CH₂CH₂OH.

  一种使耐多药细胞对抗肿瘤药物敏感的方法，包括使耐多药细胞与有效量的式化合物接触 其中 n 为 1、2 或 3、 X 是 CF₃、-O-CH₃、Br、I、Cl、H、W 和 S-CH₃ R¹ 和 R² 相互独立地为-CH₃-CH₂-CH₃、CH₂CH₂OHCH₂OH 或 NR¹ R² 形成一个环 其中 R³ 是 -CH₃、CH₂-CH₃、-H、CH₂OH 和 CH₂CH₂OH。
• Treatment of infectious diseases with combinations of a thioxanthene derivative with an anti-infective agent
  申请人：BKG Pharma ApS

  公开号：EP2260870A2

  公开（公告）日：2010-12-15

  The present invention is directed to chemosensitising compounds, in particular thioxanthene derivatives, for treatment of infectious diseases in combination with an anti-infective agent. The invention furthermore relates to compositions comprising said chemosensitising compounds and anti-infective agents.

  本发明涉及化敏化合物，特别是噻吨烷衍生物，用于与抗感染剂结合治疗传染病。本发明还涉及由上述化敏化合物和抗感染剂组成的组合物。
• US2645640
  申请人：——

  公开号：——

  公开（公告）日：——
• A Focused Library of Psychotropic Analogues with Neuroprotective and Neuroregenerative Potential
  作者：Elisa Uliassi、Luis Emiliano Peña-Altamira、Aixa V. Morales、Francesca Massenzio、Sabrina Petralla、Michele Rossi、Marinella Roberti、Loreto Martinez Gonzalez、Ana Martinez、Barbara Monti、Maria Laura Bolognesi

  DOI：10.1021/acschemneuro.8b00242

  日期：2019.1.16

  Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting simultaneously neuroprotection and neuroregeneration. In the studies reported herein, we sought to identify small molecules that might exert neuroprotective and neuroregenerative potential as tools against neurodegenerative diseases. In doing so, we started from the reported neuroprotective/neuroregenerative mechanisms of psychotropic drugs featuring a tricyclic alkylamine scaffold. Thus, we designed a focused-chemical library of 36 entries aimed at exploring the structural requirements for efficient neuroprotective/neuroregenerative cellular activity, without the manifestation of toxicity. To this aim, we developed a synthetic protocol, which overcame the limited applicability of previously reported procedures. Next, we evaluated the synthesized compounds through a phenotypic screening pipeline, based on primary neuronal systems. Phenothiazine 2Bc showed improved neuroregenerative and neuroprotective properties with respect to reference drug desipramine (2Aa). Importantly, we have also shown that 2Bc outperformed currently available drugs in cell models of Alzheimer's and Parkinson's diseases and attenuates microglial activation by reducing iNOS expression.
• TREATMENT OF INFECTIOUS DISEASES
  申请人：Bkg Pharma Aps

  公开号：EP1744781A1

  公开（公告）日：2007-01-24