1-amino-7-nitroindazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1-amino-7-nitroindazole
• 英文别名: 7-Nitroindazol-1-amine；7-nitroindazol-1-amine
• 化学式: C₇H₆N₄O₂
• 分子量: 178.15
• InChiKey: KIVIXINPOOLXOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-amino-7-nitroindazole 在 氧气 、 氧化亚氮 作用下， 以 乙腈 为溶剂， 反应 0.08h， 以92%的产率得到7-硝基吲唑
  参考文献：
  名称：

  Radical Scavenging by N -Aminoazaaromatics

  摘要：

  N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00118-8
• 作为产物：
  描述：

  7-硝基吲唑 在 2,4,6-三甲基苯磺酰羟胺 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 1-amino-7-nitroindazole
  参考文献：
  名称：

  Radical Scavenging by N -Aminoazaaromatics

  摘要：

  N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00118-8

文献信息

• Radical Scavenging by N -Aminoazaaromatics
  作者：Takashi Itoh、Michiko Miyazaki、Hiromi Maeta、Yûji Matsuya、Kazuhiro Nagata、Akio Ohsawa

  DOI：10.1016/s0968-0896(00)00118-8

  日期：2000.8

  N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. (C) 2000 Elsevier Science Ltd. All rights reserved.