4-methyl-N-((1S,2S)-2-(4-(5-methylcyclohexa-1,4-dienyl)butylamino)-1,2-diphenylethyl)benzenesulfonamide | 1404469-11-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-methyl-N-((1S,2S)-2-(4-(5-methylcyclohexa-1,4-dienyl)butylamino)-1,2-diphenylethyl)benzenesulfonamide
• 英文别名: 4-methyl-N-((1S,2S)-2-(4-(5-methylcyclohexa-1,4-dienyl)buty lamino)-1,2-diphenylethyl)benzenesulfonamide；4-methyl-N-[(1S,2S)-2-[4-(5-methylcyclohexa-1,4-dien-1-yl)butylamino]-1,2-diphenylethyl]benzenesulfonamide
• CAS: 1404469-11-9
• 化学式: C₃₂H₃₈N₂O₂S
• 分子量: 514.732
• InChiKey: WQZKNYUJKLVQJR-ACHIHNKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  、 N,N-二异丙基乙胺 、 (1S,2S)-(+)-N-对甲苯磺酰基-1,2-二苯基乙二胺 在 silica gel 、 ethyl acetate n-hexane 作用下， 以 甲苯 为溶剂， 反应 14.0h， 以Thus, 9.31 g of the title compounds were obtained as a yellow oily substance的产率得到4-methyl-N-((1S,2S)-2-(4-(5-methylcyclohexa-1,4-dienyl)butylamino)-1,2-diphenylethyl)benzenesulfonamide
  参考文献：
  名称：

  Ruthenium-diamine complex and method for producing optically active compound

  摘要：

  提供的是一种例子为（1*）的钌配合物，可用作不对称还原催化剂。（在公式中，*代表不对称碳原子；R1代表芳烃磺酰基等；R2和R3代表苯基等；R10到R14从氢原子、C1-10烷基等中选择，但R10到R14不同时为氢原子；X代表卤素原子等；j和k分别为0或1；j+k为0或2。）

  公开号：

  US08987492B2

文献信息

• RUTHENIUM-DIAMINE COMPLEX AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
  申请人：Touge Taichiro

  公开号：US20140051871A1

  公开（公告）日：2014-02-20

  Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; R 1 is an arenesulfonyl group, and the like; R 2 and R 3 are a phenyl group, and the like; R 10 through R 14 are selected from a hydrogen atom, C 1-10 alkyl group, and the like, but R 10 through R 14 are not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.)

  提供一个钌配合物，其由通式(1*)表示，可用作不对称还原催化剂。 (在公式中，*是不对称碳原子；R1是芳基磺酰基团等；R2和R3是苯基团等；R10至R14选自氢原子、C1-10烷基团等，但R10至R14不同时为氢原子；X是卤素原子等；j和k都是0或1；j+k为0或2。)
• Oxo-Tethered Ruthenium(II) Complex as a Bifunctional Catalyst for Asymmetric Transfer Hydrogenation and H₂ Hydrogenation
  作者：Taichiro Touge、Tomohiko Hakamata、Hideki Nara、Tohru Kobayashi、Noboru Sayo、Takao Saito、Yoshihito Kayaki、Takao Ikariya

  DOI：10.1021/ja207283t

  日期：2011.9.28

  Newly developed oxo-tethered Ru amido complexes (R,R)-1 and their HCl adducts (R,R)-2 exhibited excellent catalytic performance for both asymmetric transfer hydrogenation and the hydrogenation of ketonic substrates under neutral conditions without any cocatalysts to give chiral secondary alcohols with high levels of enantioselectivity.

  新开发的氧系钌酰胺络合物 (R,R)-1 及其 HCl 加合物 (R,R)-2 对不对称转移氢化和酮底物在中性条件下的氢化均表现出优异的催化性能，无需任何助催化剂即可获得手性具有高水平对映选择性的仲醇。
• METHOD FOR PRODUCING DIAMINE COMPOUND
  申请人：Touge Taichiro

  公开号：US20140039220A1

  公开（公告）日：2014-02-06

  The present invention provides a method for producing a compound represented by general formula (1) (wherein R 1 , R 2 , R 3 , R 10 -R 14 , A 1 -A 3 , n 1 and n 2 are as defined in the description), which is characterized by reacting a compound represented by general formula (2) (wherein R 10 -R 14 , A 1 -A 3 , n 1 , n 2 and B are as defined in the description) with a diamine compound represented by general formula (3) (wherein R 1 -R 3 are as defined in the description). The present invention is a method for producing a diamine compound, which is useful for the formation of a ruthenium-diamine complex, under mild conditions, said method being able to be put in industrial practice.

  本发明提供了一种生产通式（1）所代表的化合物的方法（其中R1、R2、R3、R10-R14、A1-A3、n1和n2如说明书所定义），其特征在于将通式（2）所代表的化合物（其中R10-R14、A1-A3、n1、n2和B如说明书所定义）与通式（3）所代表的二胺化合物（其中R1-R3如说明书所定义）反应。本发明是一种生产二胺化合物的方法，该方法适用于在温和条件下形成钌-二胺配合物，且能够在工业实践中应用。
• US8901323B2
  申请人：——

  公开号：US8901323B2

  公开（公告）日：2014-12-02
• US8987492B2
  申请人：——

  公开号：US8987492B2

  公开（公告）日：2015-03-24