氯二溴氟甲烷 | 353-55-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 中文名称: 氯二溴氟甲烷
• 英文名称: dibromochlorofluoromethane
• 英文别名: fluorochlorodibromomethane；chlorodibromofluoromethane；dibromo-chloro-fluoro-methane；Dibrom-chlor-fluor-methan；freon-11B₂；dibromo-chloro-fluoromethane
• CAS: 353-55-9
• 化学式: CBr₂ClF
• mdl: MFCD00010606
• 分子量: 226.27
• InChiKey: HEDKQVNHJZBFQR-UHFFFAOYSA-N

物化性质

• 沸点：
  79-80 °C(lit.)
• 密度：
  2.317 g/mL at 25 °C(lit.)
• 闪点：
  None
• 稳定性/保质期：
  避免与不相容的材料接触。

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xn,Xi
• 安全说明：
  S27,S36/37/39,S45
• 危险类别码：
  R20/21/22
• 海关编码：
  2903799090
• 储存条件：
  密封保存，应储存在阴凉干燥的仓库中。

SDS

Name:	Chlorodibromofluoromethane tech. 90% Material Safety Data Sheet
Synonym:	None Known
CAS:	353-55-9

Section 1 - Chemical Product MSDS Name:Chlorodibromofluoromethane tech. 90% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
353-55-9	Chlorodibromofluoromethane	90%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 353-55-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Clear liquid
Color: yellow to brown
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 79 - 80 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 2.3170g/cm3
Molecular Formula: ClCBr2F
Molecular Weight: 226.28

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, strong acids, strong bases.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, carbon dioxide, hydrogen fluoride gas, hydrogen bromide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 353-55-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Chlorodibromofluoromethane - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 353-55-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 353-55-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 353-55-9 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  氯二溴氟甲烷 在 difluorosilylene 、 silicon tetrafluoride 作用下， 生成
  参考文献：
  名称：

  Reactions of Difluorosilylene with Amines, Phosphines and Halomethanes The First Evidence of the Insertion of Difluorosilylene into Tetrafluorosilane

  摘要：

  AbstractThe reactions of SiF2/SiF4 with amines, phosphines and various halomethanes were studied. The results show that in the presence of strong Lewis base (Et3N, HNEt2, PR3, PR2Cl), SiF2 inserts initially into SiF4 to form Si2F6, which was followed by subsequent reactions leading to products containing SiF3 groups. This is the first report of the insertion of SiF2 into SiF4. When the reactants were a weaker base (such as RPCl2, CX3Br, X=F, Cl), insertion of SiF2 into P‐Cl and C‐Br bonds became predominant.

  DOI：

  10.1002/jccs.199900061
• 作为产物：
  描述：

  二氯氟甲烷 在 溴 作用下， 生成 氯二溴氟甲烷
  参考文献：
  名称：

  Production of dibromochlorofluoromethane from dichlorofluoromethane

  摘要：

  公开号：

  US02755314A1

文献信息

• Reactions of trifluoromethylthiocopper with halomethanes
  作者：S. Munavalli、D.I. Rossman、D.K. Rohrbaugh、C.P. Ferguson、H.D. Durst

  DOI：10.1016/0022-1139(95)03332-7

  日期：1996.1

  The reaction of trifluoromethylthiocopper with halomethanes, namely di- and triiodo-, dibromodichloro-, dibromochlorofluoro-, dibromo-difluoro-,bromochlorofluoro-, phenyltrichloro-, bromocyano- and dibromofluoro-methanes, has been investigated in detail. In addition to the expected compounds, the formation of unusual products such as bis(trifluoromethyl)trithiocarbonate, dimethyl(trifluoromethylthio)benzene

  已经详细研究了三氟甲基硫代铜与卤代甲烷，即二和三碘甲烷，二溴二氯甲烷，二溴氯氟氟烃，二溴二氟甲烷，溴氯氟氟甲烷，苯基三氯甲烷，溴氰基甲烷和二溴氟甲烷的反应。除了预期的化合物外，还会生成不寻常的产物，例如双（三氟甲基）三硫代碳酸酯，二甲基（三氟甲基硫代）苯，双（三氟甲基硫代）氟甲烷，（三氟甲基硫代）羰基氟，二硫化碳，四氯化碳，三氟甲基硫代苯甲酸酯等。被观测到。在某些情况下，已使用双（三氟甲基硫代）汞代替三氟甲基硫代铜。描述了各种产物的形成机理及其质谱碎裂行为。
• Preparation of fluorohalomethylmagnesium halides using highly active magnesium metal and their reactions
  作者：Jaroslav Kvíčala、Jan Štambaský、Martin Skalický、Oldřich Paleta

  DOI：10.1016/j.jfluchem.2005.07.016

  日期：2005.10

  Highly active magnesium (Rieke magnesium) reacts with fluorohalomethanes at −100 °C forming the corresponding fluorohalomethylmagnesium halides, which undergo nucleophilic substitution with silyl halides or nucleophilic addition with aldehydes or ketones. Whereas the stability of dibromofluoromethylmagnesium bromide (2a) was sufficient to provide acceptable product yields with dimethylphenylsilyl chloride

  高活性镁（里克镁）在-100°C下与氟代卤甲烷反应，形成相应的氟代卤代甲基镁卤化物，然后将其卤化为甲硅烷基卤化物，或与醛或酮进行亲核加成反应。而dibromofluoromethylmagnesium溴（稳定性2A）为足以提供二甲基苯基氯化铵，苯甲醛，丁醛或苯乙酮作为亲电子，其他fluoroorganomagnesium卤化物，bromodifluoromethylmagnesium溴（上可接受的产物产率图2b），溴化bromochlorofluoromethylmagnesium（2C）和碘化trifluoromethylmagnesium（2D）仅显示出非常有限的稳定性，因此与亲电试剂的相应产率较低。
• Chlorofluorocarbene from reaction of fluorotrichloromethane with reduced titanium. Synthesis of 1-chloro-1-fluorocyclopropanes
  作者：William R. Dolbier、Conrad R. Burkholder

  DOI：10.1021/jo00289a038

  日期：1990.1
• Sasson, Y.; Kitson, F.; Webster, O, W., Bulletin de la Societe Chimique de France, 1993, vol. 130, p. 599 - 600
  作者：Sasson, Y.、Kitson, F.、Webster, O, W.

  DOI：——

  日期：——
• 817. The reactions of metallic salts of acids with halogens. Part III. Some reactions of salts of fluorohalogenoacetates and of perfluoro-acids
  作者：R. N. Haszeldine

  DOI：10.1039/jr9520004259

  日期：——

表征谱图