17α-hydroxyprogesterone-3-carboxymethyloxime | 53260-10-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17α-hydroxyprogesterone-3-carboxymethyloxime
• 英文别名: 17α-Hydroxyprogesteron-3-(O-carboxymethyl)oxim；2-[[(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-ylidene]amino]oxyacetic acid
• CAS: 53260-10-9
• 化学式: C₂₃H₃₃NO₅
• 分子量: 403.519
• InChiKey: NMRMMCZURGCYED-JZTHCNPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  96.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  17α-hydroxyprogesterone-3-carboxymethyloxime 在 三乙胺 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 反应 4.5h， 生成
  参考文献：
  名称：

  Development of a plasma 17α-hydroxyprogesterone time resolved-fluorescence immunoassay involving a new biotinylated tracer

  摘要：

  A biotinylated 17 alpha-hydroxyprogesterone probe (3) was prepared from 17 alpha-hydroxyprogesterone-3-carboxymethyloxime and conjugate obtained by acylation of biotinylaminopropylammonium trifluroacetate. This new tracer was used in the development of a 17 alpha-hydroxyprogesterone time-resolved fluoroimmunoassay using streptavidin-europium. The new method was compared to a long-standing radioimmunoassay method and found to be more sensitive and economical. (C) 2000 Elsevier Science Inc. All rights reserved.

  DOI：

  10.1016/s0039-128x(99)00089-6
• 作为产物：
  描述：

  17Alpha-羟基黄体酮 、 羧甲基羟胺半盐酸盐 生成 17α-hydroxyprogesterone-3-carboxymethyloxime
  参考文献：
  名称：

  Selective 3-(O-carboxymethyl)oxime formation in steroidal 3,20-diones for hapten immunospecificity

  摘要：

  DOI：

  10.1016/0039-128x(74)90140-8

文献信息

• Selective 3-(O-carboxymethyl)oxime formation in steroidal 3,20-diones for hapten immunospecificity
  作者：Alfonso H Janoski、Franklyn C Shulman、George E Wright

  DOI：10.1016/0039-128x(74)90140-8

  日期：1974.1
• Development of a plasma 17α-hydroxyprogesterone time resolved-fluorescence immunoassay involving a new biotinylated tracer
  作者：Ahmed Boudi、Frank Giton、Hervé Galons、Bertrand Eulry、Jean-Marie Villette、Hany Soliman、Philippe Boudou、Jean Fiet

  DOI：10.1016/s0039-128x(99)00089-6

  日期：2000.2

  A biotinylated 17 alpha-hydroxyprogesterone probe (3) was prepared from 17 alpha-hydroxyprogesterone-3-carboxymethyloxime and conjugate obtained by acylation of biotinylaminopropylammonium trifluroacetate. This new tracer was used in the development of a 17 alpha-hydroxyprogesterone time-resolved fluoroimmunoassay using streptavidin-europium. The new method was compared to a long-standing radioimmunoassay method and found to be more sensitive and economical. (C) 2000 Elsevier Science Inc. All rights reserved.