2,2'-(十六烷基亚胺)二乙醇 | 18924-67-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2,2'-(十六烷基亚胺)二乙醇
• 英文名称: 2,2'-(hexadecylazanediyl)diethanol
• 英文别名: N-Hexadecyl diethanolamine；2-[hexadecyl(2-hydroxyethyl)amino]ethanol
• CAS: 18924-67-9
• 化学式: C₂₀H₄₃NO₂
• 分子量: 329.567
• InChiKey: MJWIPTSHMLSLFE-UHFFFAOYSA-N

物化性质

• 熔点：
  49-51 °C
• 沸点：
  254-256 °C(Press: 1 Torr)
• 密度：
  0.913±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  23
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• 储存条件：
  2-8℃

反应信息

• 作为反应物：
  描述：

  2,2'-(十六烷基亚胺)二乙醇 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 bis-(2-chloro-ethyl)-hexadecyl-amine
  参考文献：
  名称：

  Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

  摘要：

  Among the different PLA(2)s identified to date, the group IIA secretory PLA(2) (sPLA(2) GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 mu M). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.077
• 作为产物：
  描述：

  1-十六烷醇 在 盐酸 、 zinc(II) chloride 作用下， 以 异丙醇 为溶剂， 生成 2,2'-(十六烷基亚胺)二乙醇
  参考文献：
  名称：

  Antimicrobial and surface-active properties of cationic surfactants based on chloroalkanes and alkylbenzenes

  摘要：

  DOI：

  10.1007/bf00779905

文献信息

• Additives and products including oligoesters
  申请人：——

  公开号：US20030199593A1

  公开（公告）日：2003-10-23

  The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

  本发明涉及寡酯及其用途或添加剂的制备。含有寡酯的添加剂和/或寡酯本身可用于配制药物制剂、化妆品或个人护理产品，如洗发水和护发素。这些寡酯对于制备能够赋予调理、长效性和/或紫外线保护的多功能添加剂特别有用。描述了单独的寡酯和寡酯混合物。
• [EN] LIQUID PHOSPHITE COMPOSITION DERIVED FROM META-CRESOLS<br/>[FR] COMPOSITION LIQUIDE DE PHOSPHITES ISSUE DE MÉTA-CRÉSOLS
  申请人：CHEMTURA CORP

  公开号：WO2011014211A1

  公开（公告）日：2011-02-03

  A composition at least two different phosphites, one of which is derived from an alkylated m-cresol, wherein the composition is a liquid at ambient conditions. The other phosphites may be derived from alkylated cresol, alkylated phenol or other alkylated hydroxyaryl compounds. The cresol may be mono-alkylated or di-alkylated with a C1-C18 alkyl group.

  一种至少含有两种不同亚磷酸盐的组成物，其中一种来自烷基化间甲酚，该组成物在常温常压下为液态。其他亚磷酸盐可以来自烷基化甲酚、烷基化酚或其他烷基化羟基芳香族化合物。甲酚可以是单烷基化或二烷基化，并具有C1-C18烷基基团。
• RESIN COMPOSITION AND MOLDED PRODUCT OBTAINED BY MOLDING THE RESIN COMPOSITION
  申请人：Shibuya Atsushi

  公开号：US20100074083A1

  公开（公告）日：2010-03-25

  Provided are a resin composition comprising 100 parts by mass of the polymer having an alicyclic structure at least in a part of a repeating structural unit and 0.05 to 5 parts by mass of a hindered amine compound having a carbon atom at a ratio of from 67% by weight to 80% by weight in the molecular structure and having a molecular weight of from 500 to 3500, a novel piperidine derivative having a piperidylaminotriazine skeleton, a molded product such as an optical component obtained by molding the resin composition, and an optical pickup device which employs the optical component.

  提供的是一种树脂组合物，包括100质量部分具有环脂环结构的聚合物和0.05至5质量部分的分子结构中至少有部分碳原子的受阻胺化合物，其分子结构中碳原子占比从67%到80%。分子量在500至3500之间，一种具有哌啶氨基三嗪骨架的新型哌啶衍生物，以及通过模压树脂组合物获得的光学元件等成型产品，以及采用该光学元件的光学拾取器件。
• Alkaline Hydrolysis of Substituted Phenyl Acetates Catalyzed by Quaternary Ammonium Salts
  作者：Jiří Kulič、Jiří Sussenbek、Aleš Ptáček

  DOI：10.1135/cccc19932891

  日期：——

  Alkaline hydrolysis if the phenyl acetates CH₃COOC₆H₄X (X = 4-NO₂, 3-NO₂, 3-Cl, H, 4-CH₃, 3-CH₃, and 4-OCH₃) in the presence of hexadecyltris(2-hydroxyethyl)ammonium chloride, bis(2-hydroxyethyl)hexadecyl(methyl)ammonium bromide, and hexadecyltrimethylammonium bromide has been studied. Comparison of the rates of the hydrolysis for the above tenzides showed that the most efficient catalyst is the hexadecyltris(2-hydroxyethyl)ammonium chloride. In all cases, the rate data correlated well with structure effects by the Hammett equation.

  碱水解在十六烷基三(2-羟乙基)铵盐、双(2-羟乙基)十六烷基(甲基)铵溴化物和十六烷基三甲基铵溴化物存在下，研究了苯乙酸酯CH3COOC6H4X（X = 4-NO2、3-NO2、3-Cl、H、4-CH3、3-CH3和4-OCH3）的水解。比较了上述十种表面活性剂的水解速率，结果显示最有效的催化剂是十六烷基三(2-羟乙基)铵盐。在所有情况下，速率数据与Hammett方程的结构效应相关良好。
• The Surface Activity of Borate Surfmers with Different Hydrophobic Chain Length and Their Mixing Effect with Hexadecyl Trimethyl Ammonium Bromide
  作者：Zhengyong Liang、Lijuan Ma、Chunxu Lü、Yujia Zhai

  DOI：10.1007/s11743-011-1296-x

  日期：2012.3

  with the increase in the hydrophobic chain length and solution pH. Meanwhile, the inorganic salt addition had no obvious impact on it. The effect of chain length on the mixed system was demonstrated through regular solution theory. The synergistic interaction between borate surfmers and CTAB was studied. The chain growth favored the increase in |βm| of the mixed system, indicating a strengthening interaction

  通过表面张力法研究了不同链长，溶液pH值和无机盐添加量对合成硼酸盐表面活性剂在水溶液中表面活性的影响。硼酸盐表面活性剂与十六烷基或十六烷基三甲基溴化铵（CTAB）的混合效果受到很大的重视。结果表明，所合成的硼酸surfmers具有以最小的溶液γ优异的表面活性CMC MN 28.6·米-1（pH = 7，298 K）。硼酸盐表面活性剂的表面活性倾向于随着疏水链长度和溶液pH值的增加而增强。同时，添加无机盐对其没有明显影响。通过规则解理论证明了链长对混合体系的影响。研究了硼酸盐冲浪者与CTAB之间的协同相互作用。链增长赞成的增加|β米| 混合系统的相互作用，表明这两个组分之间的相互作用增强。