1-(m-Hydroxy-phenylazo)-2-naphthol | 20708-56-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(m-Hydroxy-phenylazo)-2-naphthol
• 英文别名: 2-Naphthalenol, 1-[(3-hydroxyphenyl)azo]-；1-[(3-hydroxyphenyl)diazenyl]naphthalen-2-ol
• CAS: 20708-56-9
• 化学式: C₁₆H₁₂N₂O₂
• 分子量: 264.283
• InChiKey: OOUMACCEQUNYKX-UHFFFAOYSA-N

物化性质

• 沸点：
  519.3±35.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(m-Hydroxy-phenylazo)-2-naphthol 生成 1-(3,4-Dihydroxyphenylazo)-2-naphthol
  参考文献：
  名称：

  Identification of 1-(3,4-Dihydroxyphenylazo)-2-hydroxynaphthalene as the Product of Oxidation of 1-Phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) by Rat Liver Microsomes

  摘要：

  致癌的偶氮染料1-苯基偶氮-2-羟基萘（苏丹I，溶剂黄14）被大鼠肝微粒体氧化为多种含偶氮代谢物。迄今为止未知结构的其中一种产物已被证实与1-(3,4-二羟基苯基偶氮)-2-羟基萘相同。该产物的鉴定完成了微粒体细胞色素P-450对苏丹I氧化的主要产物的模式。

  DOI：

  10.1135/cccc19942727
• 作为产物：
  描述：

  间硝基苯酚 生成 1-(m-Hydroxy-phenylazo)-2-naphthol
  参考文献：
  名称：

  Alfonso,L.; Kravtsov,D.N., Doklady Chemistry, 1968, vol. 179, p. 216 - 219

  摘要：

  DOI：

文献信息

• [EN] NANOPIGMENTS<br/>[FR] NANOPIGMENTS
  申请人：NVA IP HOLDINGS PTY LTD

  公开号：WO2010054441A1

  公开（公告）日：2010-05-20

  The present invention relates to a dye monomer of general formula (I): A - X - R - O - C(O) - O - CH2- C(H) = CH2,wherein A is a dye molecule and both X and R are optional linkers. The present invention also relates to particles comprising a copolymer of said dye monomer and an ethylenically unsaturated monomer, to a method of producing said particles, to the use of said particles as nanopigments and to polymer dispersions comprising said particles as nanopigments.

  本发明涉及一种一般式(I)的染料单体：A - X - R - O - C(O) - O - CH2- C(H) = CH2，其中A是染料分子，X和R均为可选的连接物。本发明还涉及包含所述染料单体和乙烯基不饱和单体的共聚物的颗粒，以及制备所述颗粒的方法，以及将所述颗粒用作纳米颜料的用途，以及包含所述颗粒作为纳米颜料的聚合物分散体。
• Aza-boronic acids as non-β-lactam inhibitors of AmpC-β-lactamase
  作者：Valentina Buzzoni、Jesus Blazquez、Stefania Ferrari、Samuele Calò、Alberto Venturelli、M.Paola Costi

  DOI：10.1016/j.bmcl.2004.05.054

  日期：2004.8

  With the aim of improving the ability of non-p-lactam inhibitors to inhibit AmpC-beta-tactamase, a series of 3-aza-phenyl-boronic acid derivatives was obtained using in parallel synthesis. The molecules were tested against Escherichia coli AmpC-beta-lactamase. The best inhibitors, 3-(2-hydroxy-naphthalen-1-ylazo)-phenyl-boronic acid (12) and 3-(2,4-dihydroxy-naphthalen-1-ylazo)-phenyl-boronic acid (14), showed apparent inhibition constant values (K-i) of 0.3 and 0.45 muM and increased the potency of the semi-synthetic cephalosporin antibiotic, ceftazidime, lowering its minimum inhibitory concentration (MIC) value of 50%, against Gram-negative bacteria strains, producing high levels of AmpC-p-lactamase. (C) 2004 Elsevier Ltd. All rights reserved.
• 59. Structure of the copper lakes of azo-dyes
  作者：H. D. K. Drew、J. K. Landquist

  DOI：10.1039/jr9380000292

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cu: MVol.B4, 186, page 1861 - 1863
  作者：

  DOI：——

  日期：——
• Identification of 1-(3,4-Dihydroxyphenylazo)-2-hydroxynaphthalene as the Product of Oxidation of 1-Phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) by Rat Liver Microsomes
  作者：Marie Stiborová、Befekadu Asfaw、Eva Frei、Heinz H. Schmeiser、Manfred Wiessler

  DOI：10.1135/cccc19942727

  日期：——

  The carcinogenic azo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14) is oxidized by rat liver microsomes to a number of azo-containing metabolites. One of the products of hitherto unknown structure has been shown to be identical with 1-(3,4-dihydroxyphenylazo)-2-hydroxynaphthalene. The identification of this product completed the pattern of major products of Sudan I oxidation by microsomal cytochrome P-450.

  致癌的偶氮染料1-苯基偶氮-2-羟基萘（苏丹I，溶剂黄14）被大鼠肝微粒体氧化为多种含偶氮代谢物。迄今为止未知结构的其中一种产物已被证实与1-(3,4-二羟基苯基偶氮)-2-羟基萘相同。该产物的鉴定完成了微粒体细胞色素P-450对苏丹I氧化的主要产物的模式。