乙基 2-巯基乙基碳酸酯 | 5628-96-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: 乙基 2-巯基乙基碳酸酯
• 中文别名: 乙基2-巯基乙基碳酸酯
• 英文名称: ethyl 2-mercaptoethyl carbonate
• 英文别名: Aethyl-<2-mercapto-aethyl>-carbonat；Carbonic acid, ethyl 2-mercaptoethyl ester；ethyl 2-sulfanylethyl carbonate
• CAS: 5628-96-6
• 化学式: C₅H₁₀O₃S
• mdl: MFCD00053519
• 分子量: 150.199
• InChiKey: MXPRJNWZZIMYNN-UHFFFAOYSA-N

物化性质

• 沸点：
  74-80 °C(Press: 7 Torr)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  36.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙基 2-巯基乙基碳酸酯 、 苯胺 在 sodium methylate 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以54%的产率得到2-(苯基氨基)-乙硫醇
  参考文献：
  名称：

  Champseix, A.; Chanet, J.; Etienne, A., Bulletin de la Societe Chimique de France, 1985, # 3, p. 463 - 472

  摘要：

  DOI：
• 作为产物：
  描述：

  氯甲酸乙酯 、 2-巯基乙醇 生成 乙基 2-巯基乙基碳酸酯
  参考文献：
  名称：

  Mercaptoethylation. IV. Preparation and Some Reactions of Alkyl 2-Hydroxyethylthiolcarbonates

  摘要：

  DOI：

  10.1021/jo01070a081

文献信息

• Polyhalo ethyl-and polyhalo vinyl-dithioethyl carbonates and thio carbonates
  申请人：BOYCHEM CORPORATION

  公开号：US03683000A1

  公开（公告）日：1972-08-08

  Compounds are prepared having one of the formulas WHERE A is selected from the group consisting of di to tetrahaloethyl and di to trihalovinyl; B is selected from the group consisting of hydrogen and -CH2OH; D is selected from the group consisting of hydrogen and E is selected from the group consisting of hydrogen and G is selected from the group consisting of hydrogen and N IS 0 OR 1, X is selected from the group consisting of oxygen and sulfur except that when n is 0 in formula (2) X must be oxygen; Q is halogen; R1 is selected from the group consisting of alkyl, phenyl, lower alkyl phenyl, halo lower alkyl, halophenyl, naphthyl, lower alkyl naphthyl and lower alkyl halophenyl; R2 and R3 individually are the same as R1 or hydrogen with the proviso that not more than one of R2 and R3 is hydrogen and collectively together with the adjacent nitrogen atom form a five to six membered heterocyclic ring having up to 1 oxygen atom therein; R4 is R1 or OR PHENYL ETHYLENE OR HALOPHENOXYMETHYL HAVING UP TO 3 HALOGENS AND UP TO 1 METHYL GROUP ON THE AROMATIC RING; K is selected from the group consisting of J is selected from the group consisting of hydrogen and ASSCH2CH2-; m is an integer from 0 to 2 inclusive, and all halogen atoms in the compounds have an atomic weight of 35 to 80.

  化合物制备的公式之一为：其中A选自二至四卤乙基和二至三卤乙烯基组成的群体；B选自氢和-CH2OH组成的群体；D选自氢；E选自氢；G选自氢；N为0或1；X选自氧和硫，但在公式（2）中当n为0时，X必须为氧；Q为卤素；R1选自烷基、苯基、低烷基苯基、卤代低烷基、卤代苯基、萘基、低烷基萘基和低烷基卤代苯基组成的群体；R2和R3分别与R1相同或为氢，但R2和R3中最多只有一个为氢，且与相邻氮原子共同形成含有最多1个氧原子的五至六元杂环环；R4为R1或苯基乙烯基或卤代苯氧基甲基，其芳香环上最多有3个卤原子和1个甲基基团；K选自J；J选自氢和ASSCH2CH2-；m为0至2的整数，化合物中的所有卤素原子的原子量为35至80。
• Steroid derivatives of cysteamine and cysteine
  作者：Owen H. Wheeler、Cesar Reyes-Zamora

  DOI：10.1139/v69-019

  日期：1969.1.1

  A number of androstenone, estrone, and pregnenone derivatives of cysteamine have been prepared by reacting the steroid amines with ethylene monothiolcarbonate. The amides of androstenone carboxylic acid with mercaptoethylamine and cysteine have also been prepared.

  已经通过类固醇胺与亚乙基单硫醇碳酸酯反应制备了许多半胱胺的雄烯酮、雌酮和孕烯酮衍生物。还制备了雄烯酮羧酸与巯基乙胺和半胱氨酸的酰胺。
• 4-Benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists
  申请人：Warner-Lambert Company

  公开号：US06284774B1

  公开（公告）日：2001-09-04

  Novel 4-Benzyl piperidine alkylsulfoxide heterocycles are disclosed and their use as subtype selective NMDA receptor antagonists, particularly for the treatment of Parkinson's disease, most preferably in combination with L-DOPA.

  揭示了新型的4-苄基哌啶烷基亚砜杂环化合物，以及它们作为亚型选择性NMDA受体拮抗剂的用途，特别适用于帕金森病的治疗，最好是与L-DOPA结合使用。
• Carbonates and thio carbonates of polyhalodisulfide alcohols
  申请人：CHEMAGRO CORPORATION

  公开号：US03629312A1

  公开（公告）日：1971-12-21
• US3784563
  申请人：——

  公开号：——

  公开（公告）日：——