2-(3-chloropropoxy)naphthalene | 56231-42-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(3-chloropropoxy)naphthalene
• 英文别名: 3-(2-naphthyloxy)-1-chloropropane
• CAS: 56231-42-6
• 化学式: C₁₃H₁₃ClO
• 分子量: 220.699
• InChiKey: QPVWDIOTNVVIDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-chloropropoxy)naphthalene 在 hexaethylene glycol bis(3-hexaethylene glycol imidazolium) dimesylate 、 potassium carbonate 作用下， 以 水 为溶剂， 反应 24.0h， 以90%的产率得到3-(2-萘基氧基)-1-丙醇
  参考文献：
  名称：

  Nucleophilic Hydroxylation in Water Media Promoted by a Hexa-Ethylene Glycol-Bridged Dicationic Ionic Liquid

  摘要：

  Hexaethylene glycol bis(3-hexaethylene glycol imidazolium) dimesylate ionic liquid (hexaEG-DHIM) was designed and prepared as a highly efficient promoter for the nucleophilic hydroxylation of alkyl halides to the corresponding alcohol products in neat water media. It was observed that hexaEG-DHIM promoter enhanced the nucleophilicity of water significantly in the reaction. In addition, the hexaEG-DHIM could be reused several times without loss of activity. Moreover, the hydroxylation reactions of base-sensitive and/or polar alkyl halide substrates proceeded highly chemoselectively in excellent yields.

  DOI：

  10.1021/acs.joc.5b00901
• 作为产物：
  描述：

  3-(2-萘基氧基)-1-丙醇 在 吡啶 、 氯化亚砜 作用下， 生成 2-(3-chloropropoxy)naphthalene
  参考文献：
  名称：

  Kirner; Richter, Journal of the American Chemical Society, 1929, vol. 51, p. 3414

  摘要：

  DOI：

文献信息

• The Synthesis of Li⁺-selective Polyether Carriers and Thier Behavior in Cation Transport through Liquid Membranes
  作者：Kazuhisa Hiratani、Kazuhiro Taguchi、Hideki Sugihara、Kokoro Iio

  DOI：10.1246/bcsj.57.1976

  日期：1984.7

  Noncyclic polyethers exhibiting lithium ion selectivity have been synthesized. Their competitive alkalimetal-ion transport through liquid membranes has been investigated, and the influence of their structures on the rates and selectivities of cation transport has been demonstrated. It has been found that the introduction of the oxytrimethylene chain on the polyethers is significant for the appearance

  已经合成了表现出锂离子选择性的非环状聚醚。已经研究了它们通过液膜的竞争性碱金属离子传输，并证明了它们的结构对阳离子传输速率和选择性的影响。已经发现，在聚醚上引入氧三亚甲基链对于锂离子高选择性的出现具有重要意义，而且端基的种类可能在决定阳离子传输速率或对锂离子的选择性。与具有未取代的喹啉基的聚醚相比，在聚醚的喹啉端基的2-位引入甲基大大提高了对锂离子的选择性。
• N-substituted alpha-arylazacycloalkylmethanamines and their use as
  申请人：A. H. Robins Company Incorporated

  公开号：US05198449A1

  公开（公告）日：1993-03-30

  Novel compounds of the formula below wherein W is azetidine, pyrrolidine or piperidine, Q is a straight chain hydrocarbon radical of 1-4 carbons and may contain a double bond, and ##STR1## Ar is phenyl, pyridinyl or pyrimidinyl, a process for their preparation, and novel intermediates are disclosed. The novel compounds and the pharmaceutical compositions of this invention are useful in the treatment of hypertension, arrhythmias and angina.

  以下是该公式的新化合物，其中W为氮杂环丙烷、吡咯烷或哌嗪，Q为含有1-4个碳原子的直链烃基，可能含有双键，Ar为苯基、吡啶基或嘧啶基。公开了它们的制备方法和新型中间体。该发明的新化合物和药物组合物在治疗高血压、心律失常和心绞痛方面具有用途。
• Synthesis and Antimicrobial Activity of Dithiocarbamates of ω-Substituted (2-naphthyloxy)alkanes
  作者：Sadaf Zaidi、Devdutt Chaturvedi、Mridula Saxena、Richa Srivastava

  DOI：10.14233/ajchem.2019.22090

  日期：2019.9.10

  A series of dithiocarbamates of ω-substituted (2-naphthyloxy) alkanes was developed through condensation of 2-(2-chloro-alkoxy)-naphthalene to various kinds of aliphatic, aromatic, alicyclic, heterocyclic primary and secondary amines employing benzyl trimethyl ammonium hydroxide in catalytic quantity (Triton-B/CS2 system) afforded desired products in high yields (82-98 %). The complete series of synthesized compounds (4-48) were evaluated for antimicrobial activity through microdilution method using various bacterial and fungal strains. The antifungal and antibacterial values were estimated as MIC values. Fluconazole and ciprofloxacin [16 to 0.03 μg/mL] were used as the standard antifungal and antibacterial drug, respectively. Out of series of evaluated compounds, some of these compounds such as compounds 28, 29, 30, 31, 32, 33 have displayed maximum potency which is comparable to standard drugs.

  一系列的ω-取代(2-萘氧基)烷基二硫代氨基甲酸盐是通过将2-(2-氯烷氧基)-萘烷基与各种脂肪、芳香、脂环、杂环的一级和二级胺进行缩合反应而制备的，使用苄基三甲基铵水氧化物作为催化剂(Triton-B/CS2系统)，产率高(82-98%)。合成的完整系列化合物(4-48)通过微稀释法对各种细菌和真菌菌株进行抗菌活性评估。抗真菌和抗菌活性值被估计为MIC值。分别使用氟康唑和环丙沙星[16至0.03 μg/mL]作为标准抗真菌和抗菌药物。在评估的化合物系列中，一些化合物如化合物28、29、30、31、32、33表现出与标准药物相当的最大效力。
• [EN] OMEGA-SUBSTITUTED-NAPHTHYLOXYALKLAMINO DERIVATIVES AS ANTIHYPERGLYCEMIC AGENTS AND PREPARATION<br/>[FR] DERIVES NAPHTYLOXYALKYLAMINO OMEGA-SUBSTITUES A TITRE D'AGENTS ANTIHYPERGLYCEMIQUES, ET LEUR PREPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2005042465A1

  公开（公告）日：2005-05-12

  This invention relates to novel o-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid-lowering effects.

  本发明涉及新型的o-取代-萘氧基-氨基烷烃，其制备和用作降血糖药物以及用于治疗和预防心血管疾病（CVS）如降脂效果。
• Alpha-substituted naphthyloxy omega-substituted alkyl/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20040192688A1

  公开（公告）日：2004-09-30

  This invention relates to novel overscore (&ohgr;)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid lowering effects.

  这项发明涉及新颖的overscore (&ohgr;)}-取代-萘氧基氨基烷烃，它们的制备和用作降糖药物以及用于治疗和预防心血管疾病（CVS）如降脂效果。