4-(Phenethyl)benzoyl chloride | 173781-70-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 4-(Phenethyl)benzoyl chloride
• 英文别名: 4-(2-phenylethyl)benzoyl chloride
• CAS: 173781-70-9
• 化学式: C₁₅H₁₃ClO
• 分子量: 244.721
• InChiKey: RYMYBKISLVMPIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  植物甾醇 、 4-(Phenethyl)benzoyl chloride 在 吡啶 作用下， 生成
  参考文献：
  名称：

  胆固醇和β-谷甾酸酯的热性质：刚性核对胆甾型和近晶A相的热稳定性的影响

  摘要：

  DOI：

  10.1021/j100276a037
• 作为产物：
  描述：

  苯甲酸,4-(2-苯基乙基)-,甲基酯 在 sodium hydroxide 、 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 16.0h， 生成 4-(Phenethyl)benzoyl chloride
  参考文献：
  名称：

  4-Aminoquinolines:  Novel Nociceptin Antagonists with Analgesic Activity

  摘要：

  Small-molecule nociceptin antagonists were synthesized to examine their therapeutic potential. After a 4-aminoquinoline derivative was found to bind with the human ORL1 receptor, a series of 4-aminoquinolines and related compounds were synthesized and their binding was evaluated. Elucidation of structure-activity relationships eventually led to the optimum compounds. One of the se compounds, N-(4-amino-2-methylquinolin-6-yl) -2-(4-ethylphenoxymethyl)benzamide hydrochloride (11) not only antagonized nociceptin-induced allodynia in mice but also showed analgesic effect in a hot plate test using mice and in a formalin test using rats. Its analgesic effect was not antagonized by the opioid antagonist naloxone. These results indicate that this nociceptin antagonist has the potential to become a novel type of analgesic that differs from mu -opioid agonists.

  DOI：

  10.1021/jm0002073

文献信息

• Novel Compounds Modulating The Hedgehog Protein Signaling Pathway, Marked Forms Thereof, And Applications
  申请人：Centre National De La Recherche Scientifique

  公开号：US20140228441A1

  公开（公告）日：2014-08-14

  The invention relates to compounds of formula (I), and the use thereof as a drug, particularly for the treatment of tumors associated with hyperactivation of the hedgehog protein signaling pathway, treatment of neurodegenerative diseases, treatment of diseases related to cerebral development (holoprosencephaly), for stem cell monitoring treatment of cerebrovascular accidents and cardiovascular accidents, treatment of diseases involving oligodendrocytes and diseases involving neurolemmocytes, for application thereof in vitro for modulating human or animal stem cell renewal, and for the treatment of diabetes. The invention also relates to pharmaceutical compositions having a compound of formula (I). The invention also relates to a method for radio-marking compounds having formula (I), the marked compounds, and the use of the compounds as research tools, and method for screening and/or identifying ligands in the Smoothened receptor (Smo) binding sites, methods for identifying agonists and antagonists of the Smoothened receptor, and a method for identifying cells.

  该发明涉及式(I)的化合物，以及其作为药物的用途，特别是用于治疗与刺刺蛋白信号通路的高活化相关的肿瘤，治疗神经退行性疾病，治疗与脑发育相关的疾病（全脑前脑发育不全），用于干细胞监测治疗脑血管事故和心血管事故，治疗涉及寡脂髓细胞和涉及神经鞘细胞的疾病，用于体外应用以调节人类或动物干细胞更新，并用于治疗糖尿病。该发明还涉及具有式(I)化合物的药物组合物。该发明还涉及一种标记具有式(I)的化合物的方法，标记的化合物，以及将化合物用作研究工具的用途，以及筛选和/或识别Smoothened受体（Smo）结合位点中配体的方法，识别Smoothened受体的激动剂和拮抗剂的方法，以及识别细胞的方法。
• Symmetrische fl�ssigkristalline Bibenzyl-4,4?-diylbisbenzoate, Synthese und Charakterisierung [1,2]
  作者：Joachim Ku�erow、Friedrich Boberg

  DOI：10.1002/prac.19943360711

  日期：——
• EP0758268A4
  申请人：——

  公开号：EP0758268A4

  公开（公告）日：1999-04-28
• POLYMER CEMENT COMPOSITIONS AND INITIATORS FOR USE IN THE PREPARATION THEREOF
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0758268A1

  公开（公告）日：1997-02-19
• NOUVEAUX COMPOSÉS MODULATEURS DE LA VOIE DE SIGNALISATION DES PROTÉINES HEDGEHOG, LEURS FORMES MARQUÉES, ET APPLICATIONS
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2758369B1

  公开（公告）日：2016-03-23