3,3-二甲基丙烯酸三甲基硅酯 | 25436-25-3

• 物质功能分类: 生物 - 细胞培养 - 培养基
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 中文名称: 3,3-二甲基丙烯酸三甲基硅酯
• 中文别名: 3，3-二甲基丙烯酸三甲基硅酯
• 英文名称: trimethylsilyl 3,3-dimethylacrylate
• 英文别名: Crotonic acid, 3-methyl-, trimethylsilyl ester；trimethylsilyl 3-methylbut-2-enoate
• CAS: 25436-25-3
• 化学式: C₈H₁₆O₂Si
• 分子量: 172.299
• InChiKey: KNFZPFSOTLGZEE-UHFFFAOYSA-N

物化性质

• 沸点：
  63 °C (13 mmHg)
• 保留指数：
  1002.7;1007.2;1015
• 稳定性/保质期：
  遵循规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 储存条件：
  存储于0至6°C的阴凉干燥处。

SDS

Name:	TRIMETHYLSILYL 3 3-DIMETHYLACRYLATE Material Safety Data Sheet
Synonym:
CAS:	25436-25-3

Section 1 - Chemical Product MSDS Name:TRIMETHYLSILYL 3 3-DIMETHYLACRYLATE Material Safety Data Sheet
Synonym:

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
25436-25-3	TRIMETHYLSILYL 3,3-DIMETHYLACRYLATE		unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation.
Chronic:
Not available.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use extinguishing media most appropriate for the surrounding fire.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

---

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a tightly closed container. Keep refrigerated. (Store below 4C/39F.)

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 25436-25-3: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 63 deg C @ 13.00mm
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight: 172.30

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 25436-25-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
TRIMETHYLSILYL 3,3-DIMETHYLACRYLATE - Not listed by ACGIH, IARC, or NTP.

---

Section 12 - ECOLOGICAL INFORMATION

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 25436-25-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 25436-25-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 25436-25-3 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,3-二甲基丙烯酸三甲基硅酯 在 盐酸 、 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 为溶剂， 反应 25.5h， 生成 大黄素
  参考文献：
  名称：

  An Expedient and Efficient Synthesis of Naturally Occurring Hydroxy Substituted Anthraquinones

  摘要：

  报道了一种通过Diels-Alder反应高产率合成天然蒽醌的通用方法。

  DOI：

  10.1055/s-1994-25452
• 作为产物：
  描述：

  三甲基氯硅烷 、 3,3-二甲基丙烯酸 在 吡啶 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以90%的产率得到3,3-二甲基丙烯酸三甲基硅酯
  参考文献：
  名称：

  Silicon in Organic Synthesis: An Improved 4-Bromination of 2-Alkenoic Acids

  摘要：

  DOI：

  10.1055/s-1983-30497

文献信息

• A New and Efficient Esterification Reaction via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid
  作者：Mitsutomo Miyashita、Isamu Shiina、So Miyoshi、Teruaki Mukaiyama

  DOI：10.1246/bcsj.66.1516

  日期：1993.5

  In the presence of a catalytic amount of Lewis acid, various carboxylic esters or S-phenyl carbothioates are prepared in excellent yields by the respective reactions of equimolar amounts of silyl carboxylates and alkyl silyl ethers or phenyl silyl sulfides with 4-trifluoromethylbenzoic anhydride.

  在催化量的路易斯酸存在下，通过等摩尔量的甲硅烷基羧酸酯和烷基甲硅烷基醚或苯基甲硅烷基硫化物与4-三氟甲基苯甲酸酐的相应反应，以极好的收率制备各种羧酸酯或S-苯基硫代碳酸酯。
• An Efficient Method for the Preparation of Carboxylic Esters via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid
  作者：Teruaki Mukaiyama、Isamu Shiina、Mitsutomo Miyashita

  DOI：10.1246/cl.1992.625

  日期：1992.4

  Various carboxylic esters are prepared in excellent yields by the reaction of nearly equimolar amounts of silyl derivatives of carboxylic acids and alcohols with p-trifluoromethylbenzoic anhydride in the presence of a catalytic amount of Lewis acid.

  在催化量的路易斯酸存在下，通过几乎等摩尔量的羧酸和醇的甲硅烷基衍生物与对三氟甲基苯甲酸酐反应，可以以极好的收率制备各种羧酸酯。
• Aizpurua, Jesus Mari; Palomo, Claudio, Synthesis, 1982, # 8, p. 684 - 686
  作者：Aizpurua, Jesus Mari、Palomo, Claudio

  DOI：——

  日期：——
• Brady, William T.; Agho, Michael O., Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 501 - 506
  作者：Brady, William T.、Agho, Michael O.

  DOI：——

  日期：——
• Zaitseva,G.S. et al., Journal of general chemistry of the USSR, 1978, vol. 48, p. 1249 - 1253
  作者：Zaitseva,G.S. et al.

  DOI：——

  日期：——

表征谱图