methyl chlorodithioformate | 16696-91-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫基化合物
• 英文名称: methyl chlorodithioformate
• 英文别名: Methylchlordithioformat；Chlordithioameisensaeure-methylester；methyl chloromethanedithioate
• CAS: 16696-91-6
• 化学式: C₂H₃ClS₂
• 分子量: 126.631
• InChiKey: CRPQEIZIDRUDJK-UHFFFAOYSA-N

物化性质

• 沸点：
  50-52 °C(Press: 15 Torr)
• 密度：
  1.378±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  methyl chlorodithioformate 、 丝裂霉素 C 在 三乙胺 作用下， 以 乙二醇二甲醚 为溶剂， 反应 1.0h， 以95%的产率得到7-amino-9a-methoxy-1a-<(methylthio)thiocarbonyl>mitosane
  参考文献：
  名称：

  Synthesis and antineoplastic activity of 1a-formyl and 1a-thioformyl derivatives of mitomycin C and 2-methylaziridine

  摘要：

  A select number of 1-formyl- and 1-thioformyl-2-methylaziridine derivatives and the corresponding 1a-substituted mitomycin C analogues were synthesized and tested for antineoplastic activity by using an in vivo test with murine P388 leukemia. Select compounds were also tested in vivo with murine melanoma B16. Several of the mitomycin C derivatives displayed activity and some of the mitomycin C analogues were comparable in activity to the parent compound.

  DOI：

  10.1021/jm00393a015
• 作为产物：
  描述：

  硫光气 、 甲硫醇 以 苯 为溶剂， 生成 methyl chlorodithioformate
  参考文献：
  名称：

  The Synthesis of Organic Trithiocarbonates¹

  摘要：

  DOI：

  10.1021/jo01068a097

文献信息

• A convenient one-step procedure for the synthesis of ketene O,S- and ketene S,S-acetals via thioacylation of malononitrile
  作者：N.H. Nilsson

  DOI：10.1016/s0040-4020(01)97571-4

  日期：1974.1

  (XO) in the presence of two equivalents of sodium hydride followed by alkylation of the intermediate thiolate anion 3. In a similar manner a number of unsymmetrical ketene S,S-acetals were synthesised via thioacylation of 1 with chlorodithioformate esters 2 (XS). The reaction of the ketene O,S-acetals with secondary amines was investigated.

  通过在两个当量的氢化钠存在下将丙二腈1与氯代硫代甲酸酯2（X = O）缩合，然后将中间体硫醇盐阴离子3烷基化，制备了酮O，S-乙缩醛。以类似的方式，通过1与氯二硫代甲酸酯2（X = S）的硫酰化反应，合成了许多不对称的乙烯酮S，S-缩醛。研究了烯酮O，S-缩醛与仲胺的反应。
• Acrylonitrile compounds, process for their production and pesticides containing them
  申请人：Ishihara Sangyo Kaisha Ltd.

  公开号：US06187944B1

  公开（公告）日：2001-02-13

  Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. wherein Q is Y is ═C(R4)— or ═N—, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen, alkyl which may be substituted, alkenyl which may be substituted, etc., R4 is hydrogen, halogen, alkyl or haloalkyl, 1 is from 1 to 4, m is from 0 to 5, n is from 0 to 3, q is from 0 to 4, when 1 is 2 or more, a plurality of R2 may be the same or different, when each of m, n and q is 2 or more, a plurality of R3 may be the same or different.

  具有杀虫活性的丙烯腈化合物的化学式（I）及其盐。其中Q是Y是═C(R4)—或═N—，R1是烷基，卤代烷基等，R2和R3中的每一个是卤素，可能被取代的烷基，可能被取代的烯基等，R4是氢，卤素，烷基或卤代烷基，1为1至4，m为0至5，n为0至3，q为0至4，当1为2或更多时，多个R2可能相同或不同，当m、n和q中的每一个为2或更多时，多个R3可能相同或不同。
• Synthesis of [1,3,5]thiadiazino[3,2-a]benzimidazole-2,4(3H)-diones and their sulphur analogues
  作者：Peter D. Howes、Max Pianka

  DOI：10.1039/p19800000762

  日期：——

  Benzimidazol-2-yl di- or tri-thiocarbonates and iso- or isothio-cyanates give, on heating in the presence of triethylamine, the novel [1,3,5]thiadiazino[3,2-a]benzimidazole-2,4(3H)-diones (11; X = Y = O) or their sulphur analogues (11; X = S, Y = O; or X = Y = S).

  在三乙胺存在下加热，苯并咪唑-2-基二硫代或三硫代碳酸酯和异硫氰酸酯或异硫氰酸酯生成新型[1,3,5]噻二嗪[3,2 - a ]苯并咪唑-2,4 （3 H）-二酮（11; X = Y = O）或它们的硫类似物（11; X = S，Y = O;或X = Y = S）。
• A Simple Route to 2-Alkenethioic<i>O</i>-Esters and 2-Alkenedithioic Esters [Thiono- and Dithioesters, 37]
  作者：K. Hartke、O. Kunze、W. Hoederath

  DOI：10.1055/s-1985-31402

  日期：——

  The reaction of the copper(I) derivative of dimethyl methanephosphonic ester with O-alkyl carbonochloridothioates affords O-alkyl (dimethoxyphosphinyl)-thioacetates. These compounds as well as the corresponding dithioesters react with aldehydes in a Horner-Emmons reaction to give O-alkyl 2-alkenethioates or alkyl 2-alkenedithioates, respectively.

  二甲基甲烷膦酸铜(I)衍生物与 O-烷基碳酰氯硫代酸酯反应生成 O-烷基（二甲氧基膦酰基）硫代酸酯。这些化合物以及相应的二硫代酯与醛发生 Horner-Emmons 反应，分别生成 O-烷基 2-亚烷基硫代酸酯或 O-烷基 2-亚烷基硫代酸酯。
• α,β-acetylenic dithio and thiono esters
  作者：Klaus Hartke、Hans-Dieter Gerber、Ulrich Roesrath

  DOI：10.1016/s0040-4039(01)80363-4

  日期：1989.1

  The α,β-acetylenic dithio and thiono esters and have been prepared by thiolysis of the iminium salts , by a palladium (II) catalyzed condensation of the acetylenes with the thiocarbonyl chlorides or , and by a thiocarbonylation of the magnesium acetylides with the thionocarbonyl chloride .

  α，β-炔属二硫代和硫代酸酯，是通过亚胺盐的硫解，钯（II）催化的乙炔与硫代羰基氯化物的缩合反应或乙炔化镁与硫代羰基氯化物的硫代羰基化反应制得的。。