2-[4-(1,3-benzothiazol-2-yl)phenyl]-1,3-dihydro-2H-isoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[4-(1,3-benzothiazol-2-yl)phenyl]-1,3-dihydro-2H-isoindole-1,3-dione
• 英文别名: 2-[4-(1,3-Benzothiazol-2-yl)phenyl]isoindole-1,3-dione
• 化学式: C₂₁H₁₂N₂O₂S
• 分子量: 356.404
• InChiKey: STNMLKNNNPSEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氨基苯甲醛 在 硼酸 作用下， 反应 2.0h， 生成 2-[4-(1,3-benzothiazol-2-yl)phenyl]-1,3-dihydro-2H-isoindole-1,3-dione
  参考文献：
  名称：

  PEG-600-Mediated Efficient and Environmentally Sustainable Synthesis of N-[4-(1H-Benzazole-2-yl)phenyl]phthalimides

  摘要：

  An economically and environmentally sustainable protocol has been proposed for the synthesis ofN-[4-(1H-benzazole-2-yl)phenyl]phthalimides via stepwise and tandem reactions of phthalic anhydride, 4-aminobenzaldehyde, ando-phenylenediamine,N-methyl-o-phenylenediamine, 2-aminobenzenethiol, or 2-aminophenol in PEG-600 for 2-3 h in the presence of boric acid as catalyst. Binding of the synthesized molecules to the tubulin protein (PDB ID: 5CA1) was simulated using AutoDock. All molecules showed good binding energies as compared to Nocodazole. This simple methodology could be useful for environmentally sustainable chemistry with the advantages including shorter reaction time, nontoxic and nonhazardous catalyst, and mild conditions.

  DOI：

  10.1134/s1070428020070246

文献信息

• 一种基于苯并噻唑的可视化检测肼的荧光探针及其制备方法和用途
  申请人：湖北理工学院

  公开号：CN107880034A

  公开（公告）日：2018-04-06

  本发明提供了一种基于苯并噻唑的可视化检测肼的荧光探针ZY9及其制备方法和用途。这种荧光探针ZY9可通过2‑(4‑氨基苯基)苯并噻唑和邻苯二甲酸酐按照一定的比例反应得到，合成、纯化简单，产率较高，成本低廉；本发明的肼荧光探针是一种荧光增强型荧光探针，它对肼具有较高的选择性和灵敏度，抗干扰能力强，响应快，能够通过荧光颜色的明显变化实现对肼的可视化检测；该探针稳定性好，可长期保存使用；另外，该探针适合对细胞中的肼含量进行检测，实现在活细胞水平中肼的荧光成像，而且探针试纸也可检测一定浓度水溶液中的肼。使用本发明的肼检测方法有操作简便，易于推广等优点，在环境和生物科学领域将具有广阔的应用前景。
• PEG-600-Mediated Efficient and Environmentally Sustainable Synthesis of N-[4-(1H-Benzazole-2-yl)phenyl]phthalimides
  作者：P. Karunakar、C. N. S. S. P. Kumar

  DOI：10.1134/s1070428020070246

  日期：2020.7

  An economically and environmentally sustainable protocol has been proposed for the synthesis ofN-[4-(1H-benzazole-2-yl)phenyl]phthalimides via stepwise and tandem reactions of phthalic anhydride, 4-aminobenzaldehyde, ando-phenylenediamine,N-methyl-o-phenylenediamine, 2-aminobenzenethiol, or 2-aminophenol in PEG-600 for 2-3 h in the presence of boric acid as catalyst. Binding of the synthesized molecules to the tubulin protein (PDB ID: 5CA1) was simulated using AutoDock. All molecules showed good binding energies as compared to Nocodazole. This simple methodology could be useful for environmentally sustainable chemistry with the advantages including shorter reaction time, nontoxic and nonhazardous catalyst, and mild conditions.