2,2-bis(azidomethyl)trimethylene carbonate | 1266359-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2,2-bis(azidomethyl)trimethylene carbonate
• 英文别名: 5,5-bis(azidomethyl)-1,3-dioxane-2-one；AzDXO；5,5-Bis(azidomethyl)-1,3-dioxan-2-one
• CAS: 1266359-20-9
• 化学式: C₆H₈N₆O₃
• 分子量: 212.168
• InChiKey: JZOFRECICSBFEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  二溴新戊二醇 在 sodium azide 、 三乙胺 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 16.0h， 生成 2,2-bis(azidomethyl)trimethylene carbonate
  参考文献：
  名称：

  [EN] MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY (ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS
  [FR] MONOMÈRES ET POLYMÈRES POUR POLYCARBONATES ET POLY(ESTER-CARBONATES) FONCTIONNELS ET HYDROGELS DE PEG-CO-POLYCARBONATE

  摘要：

  这项发明通常涉及功能性聚合物和水凝胶。更具体地，该发明提供了具有明确定义功能的多用途单体和聚合物，例如聚碳酸酯和聚（酯碳酸酯），以及它们的组合物，以及制备和使用它们的方法。该发明还提供了细胞相容性的聚乙二醇-共聚碳酸酯水凝胶（例如，通过无铜、应变促进的“点击”化学交联）。

  公开号：

  WO2012116250A1

文献信息

• Monomers and polymers for functional polycarbonates and poly(ester-carbonates) and peg-co-polycarbonate hydrogels
  申请人：University of Massachusetts Medical School

  公开号：US10752614B2

  公开（公告）日：2020-08-25

  The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. The invention also provides cytocompatible poly(ethylene glycol)-co-polycarobonate hydrogels (e.g., crosslinked by copper-free, strain-promoted “click” chemistry).

  本发明一般涉及功能性聚合物和水凝胶。更具体地说，本发明提供了具有明确功能性的多功能单体和聚合物，例如聚碳酸酯和聚（酯-碳酸酯）、其组合物以及制造和使用它们的方法。本发明还提供了细胞相容性聚（乙二醇）-共聚碳酸酯水凝胶（例如，通过无铜、应变促进的 "点击 "化学法交联）。
• Preparation of Azido Polycarbonates and Their Functionalization via Click Chemistry
  作者：Xiaojin Zhang、Zhenlin Zhong、Renxi Zhuo

  DOI：10.1021/ma200137a

  日期：2011.4.12
• A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester−carbonates)
  作者：Jianwen Xu、Fioleda Prifti、Jie Song

  DOI：10.1021/ma200021m

  日期：2011.4.26

  Despite the increasing demands for functional degradable biomatetials, strategies for generating materials with modular compositions and well-defined functionalities from common building blocks are still lacking. Here we report an azido-functionalized cyclic carbonate monomer, AzDXO, that exhibited controlled/"living" ring-opening polymerization kinetics under the catalysis of 1,8-diazabicyclo[5.4.0]undec-7-ene. Homopolymerization of AzDXO and copolymerization of AzDXO with lactide resulted in polycarbonate and poly-(ester-carbonate) with well-defined composition and narrow polydispersity. Further side-chain functioalizations of these polymers were accomplished under facile conditions via copper-catalyzed or copper-flee strain-promoted azido-allcyne cyclcoaddition. This versatile monomer building block, obtainable in two steps without tedious purifications, provides a practical solution to the preparation of well-defined functional polycarbonates and poly(ester-carbonates).
• MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY (ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS
  申请人：University of Massachusetts Medical School

  公开号：EP2678326B1

  公开（公告）日：2017-08-02
• MONOMERS AND POLYMERS FOR FUNCTIONAL POLYCARBONATES AND POLY(ESTER-CARBONATES) AND PEG-CO-POLYCARBONATE HYDROGELS
  申请人：Song Jie

  公开号：US20140058058A1

  公开（公告）日：2014-02-27

  The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. The invention also provides cytocompatible poly(ethylene glycol)-co-polycarobonate hydrogels (e.g., crosslinked by copper-free, strain-promoted “click” chemistry).