Hexahydrocannabinol | 1972-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Hexahydrocannabinol
• 英文别名: 6,6,9-trimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol；6,6,9-trimethyl-3-pentyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
• CAS: 1972-09-4；6692-85-9
• 化学式: C₂₁H₃₂O₂
• 分子量: 316.484
• InChiKey: XKRHRBJLCLXSGE-UHFFFAOYSA-N

物化性质

• 沸点：
  390.2±31.0 °C(Predicted)
• 密度：
  0.993±0.06 g/cm3(Predicted)
• 保留指数：
  2407

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol 在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 25.0~50.0 ℃ 、500.01 kPa 条件下， 生成 Hexahydrocannabinol
  参考文献：
  名称：

  WO2023/4414

  摘要：

  公开号：

文献信息

• Oral solid cannabinoid formulations, methods for producing and using thereof
  申请人：GELPELL AG

  公开号：US10555906B2

  公开（公告）日：2020-02-11

  Provided are solid oral/per os formulations that include a single cannabinoid, combination of cannabinoids, cannabis extract and combination of cannabis plant constituents. Also provided are methods of making the formulations, as well as therapeutic applications in the treatment and alleviation of various human disorders and/or conditions.

  所提供的固体口服/口服制剂包括单一大麻素、大麻素组合、大麻提取物和大麻植物成分组合。还提供了制作这些制剂的方法，以及在治疗和缓解人类各种疾病和/或病症方面的治疗应用。
• Methods and compositions for treating cancer
  申请人：Sutter West Bay Hospitals

  公开号：US11344527B2

  公开（公告）日：2022-05-31

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.

  本公开提供了用于治疗包括癌症在内的细胞增殖性疾病的组合物和方法。本公开提供了大麻二酚衍生物及其单独或与四氢大麻酚或其衍生物结合使用的组合物。
• Murphy, William S.; Culhane, Anne; Duffy, Brian, Journal of the Chemical Society. Perkin transactions I, 1992, # 24, p. 3397 - 3400
  作者：Murphy, William S.、Culhane, Anne、Duffy, Brian、Tuladhar, Sudersan Man

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR TREATING CANCER
  申请人：McAllister Sean D.

  公开号：US20100204312A1

  公开（公告）日：2010-08-12

  This disclosure provides compositions and method useful for treating cell proliferative disorders including cancer. The disclosure provides cannabidiol derivatives and compositions thereof either alone or in combination with THC or a derivative thereof.
• ORAL SOLID CANNABINOID FORMULATIONS, METHODS FOR PRODUCING AND USING THEREOF
  申请人：GELPELL AG

  公开号：US20180078504A1

  公开（公告）日：2018-03-22

  Provided are solid oral/per os formulations that include a single cannabinoid, combination of cannabinoids, cannabis extract and combination of cannabis plant constituents. Also provided are methods of making the formulations, as well as therapeutic applications in the treatment and alleviation of various human disorders and/or conditions.

表征谱图