ethyl 3-(4-trityloxyphenoxy)benzyl butylphosphonate | 955120-80-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: ethyl 3-(4-trityloxyphenoxy)benzyl butylphosphonate
• 英文别名: 1-[(Butyl-ethoxy-oxidophosphaniumyl)oxymethyl]-3-(4-trityloxyphenoxy)benzene；1-[(butyl-ethoxy-oxidophosphaniumyl)oxymethyl]-3-(4-trityloxyphenoxy)benzene
• CAS: 955120-80-6
• 化学式: C₃₈H₃₉O₅P
• 分子量: 606.698
• InChiKey: BYLVMQXMUJPNOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  44
• 可旋转键数：
  15
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  60
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 3-(4-trityloxyphenoxy)benzyl butylphosphonate 在 溶剂黄146 作用下， 反应 7.5h， 以72%的产率得到ethyl 3-(4-hydroxyphenoxy)benzyl butylphosphonate
  参考文献：
  名称：

  Synthesis of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors

  摘要：

  All three isomers of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors were synthesized from 3-bromobenzoic acid using Ullman diaryl ether synthesis combined with benzyl- and trityl protection strategy for the phenol hydroxyl groups. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.078
• 作为产物：
  描述：

  4-苄氧基苯酚 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 、 sodium hydride 、 三乙胺 、 copper(l) chloride 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 9.0h， 生成 ethyl 3-(4-trityloxyphenoxy)benzyl butylphosphonate
  参考文献：
  名称：

  Synthesis of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors

  摘要：

  All three isomers of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors were synthesized from 3-bromobenzoic acid using Ullman diaryl ether synthesis combined with benzyl- and trityl protection strategy for the phenol hydroxyl groups. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.07.078

文献信息

• Synthesis of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors
  作者：Rok Frlan、Stanislav Gobec、Danijel Kikelj

  DOI：10.1016/j.tet.2007.07.078

  日期：2007.10

  All three isomers of ethyl 3-(hydroxyphenoxy)benzyl butylphosphonates as potential antigen 85C inhibitors were synthesized from 3-bromobenzoic acid using Ullman diaryl ether synthesis combined with benzyl- and trityl protection strategy for the phenol hydroxyl groups. (C) 2007 Elsevier Ltd. All rights reserved.