10-decenyl isocyanate | 13231-76-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 10-decenyl isocyanate
• 英文别名: dec-9-enylisocyanate；10-isocyanatodecene；9-decenyl isocyanate；9-n-Decenylisocyanat；9-Decenyl-isocyanat；10-Isocyanatodec-1-ene
• CAS: 13231-76-0
• 化学式: C₁₁H₁₉NO
• 分子量: 181.278
• InChiKey: RDKLNZXBKGJRIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-decenyl isocyanate 在 chloroplatinic acid 1,1,3,3-tetramethyl-1,3-divinyldisiloxane complex 作用下， 以 乙腈 为溶剂， 反应 6.0h， 生成 9-fluorenylmethyl 1-[(triethoxysilyldecyl)aminocarbonyl]-2-hydrazinecarboxylate
  参考文献：
  名称：

  通过肽与功能化多分散二氧化硅颗粒的位点特异性连接制备的混合生物有机-无机材料

  摘要：

  我们描述了氨基脲或乙醛酰官能化的多分散二氧化硅颗粒的合成及其在制备混合多肽-二氧化硅材料中的用途。通过位点特异性 α-氧腙或缩氨基脲连接将肽连接到功能化二氧化硅的表面。发现氨基脲二氧化硅与模型乙醛肽的反应在化学计量条件下非常有效，并导致约 90% 的连接产率。乙醛基二氧化硅和肼基乙酰肽的使用导致较低的产率。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

  DOI：

  10.1002/ejoc.200400839
• 作为产物：
  描述：

  2-十一烯酸 在 二苯基磷酸 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以92%的产率得到10-decenyl isocyanate
  参考文献：
  名称：

  Biomimetic Design of Reversibly Unfolding Cross-Linker to Enhance Mechanical Properties of 3D Network Polymers

  摘要：

  We report here a biomimetic design of a reversibly unfolding modular cross-linker to enhance mechanical properties of 3D network polymers. The inspiration comes from the modular biopolymers observed in nature. A cyclic modular cross-linker based on the quadruple hydrogen bonding 4-ureido-2-pyrimidone (UPy) motif was synthesized via multistep organic synthesis. The modular crosslinker was incorporated into poly(n -butyl acrylate) by free radical polymerization. Stress-strain measurements show that the samples containing our modular cross-linker exhibit significantly enhanced mechanical properties over the control samples. Most strikingly, with increasing cross-linker density, both modulus and tensile strength are significantly improved without sacrificing extensibility. The enhanced tensile properties are attributed to the increased energy dissipating ability of the reversibly unfolding cross-linker. This introduces a novel biomimetic concept to enhance network mechanical properties through design of molecularly engineered cross-linkers.

  DOI：

  10.1021/ja0742176

文献信息

• Substituted hydroxyureas
  申请人：Ortho Pharmaceutical Corporation

  公开号：US05066658A1

  公开（公告）日：1991-11-19

  The present invention relates to substituted hydroxyureas. These compounds inhibit the enzyme 5-lipoxygenase. In addition, certain of the compounds also inhibit the enzyme-cyclooxygenase. The compounds are useful for treating asthma, allergies, arthritis, posoriasis, ischemia, dermatitis, inflammation and/or broncho-constriction and/or inflammatory diseases of the eye.

  本发明涉及取代脲醇。这些化合物抑制5-脂氧合酶酶。此外，其中某些化合物还抑制酶-环氧合酶。这些化合物用于治疗哮喘、过敏、关节炎、银屑病、缺血、皮炎、炎症和/或支气管收缩和/或眼部炎症性疾病。
• Epoxy-Terminated Self-Assembled Monolayers Containing Internal Urea or Amide Groups
  作者：Michaël A. Ramin、Gwénaëlle Le Bourdon、Karine Heuzé、Marie Degueil、Thierry Buffeteau、Bernard Bennetau、Luc Vellutini

  DOI：10.1021/la5049375

  日期：2015.3.10

  internal amide or urea groups possessing an epoxy-terminal group and trimethoxysilyl-anchoring group. The structural characterizations of the corresponding self-assembled monolayers (SAMs) were performed by polarization modulation infrared reflection adsorption spectroscopy (PM–IRRAS). The molecular assembly is mainly based on the intermolecular hydrogen-bonding between adjacent amide or urea groups in the

  我们报道了具有内部酰胺基或脲基的新型偶联剂的合成，所述酰胺基或脲基具有环氧基端基和三甲氧基甲硅烷基-锚定基团。相应的自组装单分子层（SAMs）的结构表征是通过偏振调制红外反射吸收光谱法（PM-IRRAS）进行的。分子组装主要基于单层中相邻酰胺或脲基团之间的分子间氢键。由于酰胺或脲基的空间位阻，烷基链之间的距离太大而无法建立范德华相互作用，从而引起它们的紊乱。通过与荧光探针反应成功地研究了环氧基末端基团的反应性。22）缩水甘油基封端的SAM。
• Amidinoureas
  申请人：Sterling Drug Inc.

  公开号：US03988370A1

  公开（公告）日：1976-10-26

  Antibacterial and antifungal mono- and disubstituted amidinoureas and amidinothioureas are obtained by interaction of guanidines and isocyanates or isothiocyanates.

  抗菌和抗真菌的单取代和双取代的胍脲和胍硫脲是通过胍胺和异氰酸酯或异硫氰酸酯的相互作用获得的。
• BACTERIOSTATS: III. OXYAMINES AND THEIR DERIVATIVES
  作者：A. F. McKay、D. L. Garmaise、G. Y. Paris、S. Gelblum

  DOI：10.1139/v60-050

  日期：1960.3.1

  A number of benzyloxyamines were prepared for conversion into urea and thiourea derivatives. The benzyloxyamine hydrochlorides on treatment with phosgene gave a mixture of the corresponding benzyl 4-(benzyloxy)-allophanate and benzyloxycarbamyl chloride. Triethylamine converted the benzyloxycarbamyl chlorides into the corresponding 1,3,5-tri-(benzyloxy)-isocyanuric acids. The reactions of the allophanates with amines and sodium hydroxide are described.

  为合成脲和硫脲衍生物，制备了一系列苄氧胺。苄氧胺盐酸盐与光气处理后生成相应的苄基4-(苄氧基)-异尿酸酯和苄氧基氨基甲酰氯的混合物。三乙胺将苄氧基氨基甲酰氯转化为相应的1,3,5-三-(苄氧基)-异氰酸酸。描述了异尿酸酯与胺和氢氧化钠的反应。
• Anti-Inflammatory Agents
  申请人：Grainger David John

  公开号：US20080227724A1

  公开（公告）日：2008-09-18

  The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof; wherein X is —CO—R 1 or —SO 2 —R 2 , and R 1 and R 2 are carbonaceous substituents.

  本发明涉及使用3-氨基己内酯衍生物制备用于预防或治疗炎症性疾病的药物，使用一般式(I)的化合物或其药学上可接受的盐；其中X为—CO—R1或—SO2—R2，而R1和R2为碳取代基。