1,4-二(吡啶-4-基甲基)哌嗪 | 357429-12-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1,4-二(吡啶-4-基甲基)哌嗪
• 英文名称: 1,4-bis(pyridin-4-ylmethyl)piperazine
• 英文别名: bis(4-pyridylmethyl)piperazine；N,N'-bis(4-pyridylmethyl)piperazine；4-bpmp；1,4-bis(4-pyridylmethyl)piperazine；bpmp；1,4-bis(4-pyridinylmethyl)piperazine；1,4-bis(4-pyridylmethy) piperazine
• CAS: 357429-12-0
• 化学式: C₁₆H₂₀N₄
• 分子量: 268.362
• InChiKey: PVAQSGXNQUFOMY-UHFFFAOYSA-N

物化性质

• 熔点：
  180 °C
• 沸点：
  421.3±40.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cis-(2,2'-bipyridine)dinitratopalladium(II) 、 1,4-二(吡啶-4-基甲基)哌嗪 以 乙腈 为溶剂， 反应 5.0h， 以93%的产率得到[Pd₂(2,2′-bipyridyl)₂(bis(4-pyridylmethyl)piperazine)₂](NO₃)₄
  参考文献：
  名称：

  Toppled Molecular-Domino Sets by Self-Assembly of Self-assembly: The π-Polymers

  摘要：

  A series of designed binuclear palladium(II)-based self-assemblies, [Pd-2(en)(2)(L)(2)](NO3)(4), 1a; [Pd-2-(tmeda)(2)(L)(2)](NO3)(4), 2a; [Pd-2(bpy)(2)(L)(2)](NO3)(4), 3a; and [Pd-2(phen)(2)(L)(2)](NO3)(4), 4a, are synthesized. These complexes are obtained in good to excellent yields by equimolar combination of the nonchelating bidentate ligand bis(4-pyridylmethyl)piperazine, L, with the corresponding cis-protected palladium(II) component, that is, Pd(N-N)(NO3)(2), under suitable reaction conditions. The cis-protecting N-N units used are ethylenediamine (en), tetramethylethylenediamine (tmeda), 2,2'-bipyridyl (bpy), and 1,10-phenanthroline (phen). The complexes 1a-4a are well-characterized by H-1 NMR, H-H COSY, and HSQC, and the molecular compositions have been established by ESI-MS. The molecular structures are confirmed for the complexes [Pd-2(tmeda)(2)(L)(2)](ClO4)(4), 2b; [Pd-2(bpy)(2)(L)(2)](ClO4)(4), 3b; and [Pd-2(phen)(2)(L)(2)](NO3)(4), 4a, by the single-crystal X-ray diffraction technique. In the cases of the complexes 3b and 4a, the crystal packing diagrams display a unique one-dimensional predefined organization of molecules by intermolecular pi-pi interactions using the strategically located pi-surfaces of the cis-protecting units. This organization resembles a set of toppled dominos. A given set exhibits further interactions with the neighboring sets in the packing pattern that are influenced by the nature of the N-N moiety, for example, bpy or phen. However, no such arrangement is observed in the case of the complex 2b due to the lack of a pi-surface at the cis-protecting moiety.

  DOI：

  10.1021/cg400781x
• 作为产物：
  描述：

  哌嗪 、 4-氯甲基吡啶盐酸盐 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 1,4-二(吡啶-4-基甲基)哌嗪
  参考文献：
  名称：

  由双（4-吡啶基甲基）哌嗪和间苯二甲酸衍生物合成的发光镉配位聚合物

  摘要：

  摘要硝酸镉，5-取代的间苯二甲酸衍生物和长跨度的双（4-吡啶基甲基）哌嗪（4-bpmp）配体的水热反应提供了一系列晶体配位聚合物，其拓扑结构和互穿方式关键取决于性质。 5位取代基的R 2。{[Cd（mip）（4-bpmp）（H 2 O）]·3H 2 O} n（1，mip = 5-间苯二甲酸甲酯）和{[Cd（nip）（4-bpmp）（H 2 O）] ·3H 2 O} n（2，nip = 5-硝基间苯二甲酸酯）均显示（4,4）网格拓扑。{[Cd 4（hip）4（H 2 O）4（4-bpmpH）2]（hip）·15H 2 O} n（3，hip = 5-羟基间苯二甲酸酯）也表现出（4,4）网格拓扑，但基于{Cd 2 O 2}和{Cd 2（OCO）2}二聚体单元。[Cd（meoip）（4-bpmp）] n（4，meoip = 5-甲氧基间苯二甲酸酯）显示了仅基于{Cd 2（OCO）2}二聚体单元的（4

  DOI：

  10.1016/j.ica.2017.01.009

文献信息

• A series of coordination polymers based on terphenyl tetracarboxylates and bis-pyridyl ligands with water vapor sorption properties
  作者：Ling Li、Lei Lv、Ru-Dan Huang

  DOI：10.1039/c6ra25319a

  日期：——

  Six new coordination polymers, namely, [Mn2(L1)(bpfp)(H2O)2]·6H2O·(CH3OH)}n (1), [Mn4(μ3-O)2(L1)2(bpe)2(H2O)2]·2H2O}n (2), [Ni(HL1)(Hbpmp)(H2O)2]n (3), [Co2(μ2-OH)(HL1)(bpmp)(H2O)4]n (4), [Co2(L2)(bpfp)(H2O)2]·4H2O}n (5), [Co2(L2)2(bpe)2(H2O)2·2H2O]·(NH4)4}n (6) (H4L1 = [1,1′:4′,1′′-terphenyl]-2,2′′,5,5′′-tetracarboxylic acid, H4L2 = [1,1′:4′,1′′-terphenyl]-3,3′′,5,5′′-tetracarboxylic acid, bpfp

  六个新的配位聚合物，即，[锰2（L1）（bpfp）（H 2 O）2 ]·6H 2 O·（CH 3 OH）} Ñ（1），[锰4（μ 3 -O）2（L1）2（bpe）2（H 2 O）2 ]·2H 2 O} n（2），[Ni（HL1）（Hbpmp）（H 2 O）2 ] n（3），[Co 2（ μ 2 -OH）（HL1）（的Bpmp）（H 2 O）4 ] ñ（4），[Co 2（L2）（bpfp）（H 2 O）2 ]·4H 2 O} n（5），[Co 2（L2）2（bpe）2（H 2 O）2 · 2H 2 O]·（NH 4）4 } n（6）（H 4 L1 = [1,1'：4'，1''-三联苯] -2,2''，5,5''-四羧酸，H 4 L2 = [1,1'：4'，1''-三联苯] -3,3''，5,5''-四羧酸，bpfp =双（4-吡啶基甲酰基）哌嗪，bpe = 1， 2-双（吡啶-4-基）乙烷和bpmp
• Structural and functional studies on coordination polymers based on 5-tert-butylisophthalic acid and N,N′-bis-(4-pyridylmethyl) piperazine
  作者：Bo Xu、Yi-Qiang Sun、Jie Li、Cun-Cheng Li

  DOI：10.1039/c4ra03569k

  日期：——

  By using 5-tert-butylisophthalic acid (H2tbip) and N,N′-bis-(4-pyridylmethyl) piperazine (bpmp), three coordination polymers formulated as [Co(bpmp)(tbip)]·H2O}n (1), [Ni(bpmp)1.5(tbip)(H2O)]·H2O}n (2), and [Cd(bpmp)1.5(tbip)]·3H2O}n (3) have been synthesized under hydrothermal conditions. All complexes were characterized by single crystal X-ray diffraction analysis, powder X-ray diffraction analysis, elemental analysis, infrared spectroscopy and thermogravimetric analysis. The results show that complex 1 presents a 3D 6-connected network. Complex 2 shows a three-fold interpenetrating framework based on subunits with 46.64}-bnn hexagonal BN topology while complex 3 shows a 2D → 3D polycatenation framework containing 2D bilayer motifs as the fundamental building units. The photocatalytic properties of complexes 1 and 2 have been evaluated and the results show that they are active as a catalyst for the decomposition of Rhodamine B under visible light. The photoluminescence properties of complex 3 were also assessed in the solid state at room temperature.

  通过使用5-叔丁基异苯二酸（H₂tbip）和N,N'-双（4-吡啶甲基）哌嗪（bpmp），在水热条件下合成了三种配位聚合物，分别为[Co(bpmp)(tbip)]·H₂O}n（1），[Ni(bpmp)1.5(tbip)(H₂O)]·H₂O}n（2），和[Cd(bpmp)1.5(tbip)]·3H₂O}n（3）。所有复合物均通过单晶X射线衍射分析、粉末X射线衍射分析、元素分析、红外光谱和热重分析进行了表征。结果表明，复合物1呈现出一个3D 6连接网络。复合物2基于具有46.64}-bnn六角形BN拓扑的子单元，表现出一种三重相互渗透的框架，而复合物3则展示了一种包含2D双层结构作为基本构建单元的2D→3D多链框架。复合物1和2的光催化性能得到了评估，结果显示它们在可见光照射下作为催化剂对罗丹明B的分解具有活性。复合物3的光致发光性质也在室温下的固态中进行了评估。
• Silver nitrate molecular species and coordination polymers with divergent supramolecular morphology constructed from hydrogen-bonding capable dipyridyl ligands
  作者：Gregory A. Farnum、Warren R. Knapp、Robert L. LaDuca

  DOI：10.1016/j.poly.2008.10.028

  日期：2009.2

  coordination polymers and one discrete cationic species with diverse silver coordination spheres. [Ag(NO3)(4,4′-dpk)]n (1, 4,4′-dpk = 4,4′-dipyridylketone), [Ag(4-bpmp)](NO3) · 6H2O} (2, 4-bpmp = bis(4-pyridylmethyl)piperazine) and [Ag2(NO3)(3-bpmp)(H2O)2]NO3}n (3, 3-bpmp = bis(3-pyridylmethyl)piperazine) all display 1-D coordination polymer chain or ribbon motifs. Long-range Ag⋯O interactions and/or hydrogen-bonding

  摘要硝酸银与各种具有氢键结合能力的二吡啶基配体发生固溶反应，生成了三种一维配位聚合物和一种具有多种银配位球的离散阳离子。[Ag（NO3）（4,4'-dpk）] n（1，4,4'-dpk = 4,4'-dipyridylketone），[Ag（4-bpmp）]（ ）·6 }（2 ，4-bpmp =双（4-吡啶基甲基）哌嗪）和[Ag2（ ）（3-bpmp）（H2O）2] } n（3，3-bpmp =双（3-吡啶基甲基）哌嗪）全部显示一维配位聚合物链或丝带图案。远距离的Ag⋯O相互作用和/或氢键促进形成不同的超分子聚集体，例如1中的2-D双层平板，2中的三重互穿的3-D Diamondoid网络和2-D单层图3中的化合物2在其初始空隙中显示出“无限”的1-DT（5）2水分子带。[Ag（2，4'-pmpp）2]（ ）· }（4，2,4'-pmpp = 2-吡啶基（4
• Nitroaromatic-detecting cadmium cyclohexyldicarboxylate coordination polymers with bis(4-pyridylmethyl)piperazine coligands and unprecedented 2D and 3D topologies
  作者：Andrew R. LaDuca、Robert L. LaDuca

  DOI：10.1039/c8ce01041b

  日期：——

  Hydrothermal reaction of cadmium nitrate, bis(4-pyridylmethyl)piperazine (4-bpmp), and a variety of cyclohexyldicarboxylate ligands generated three new coordination polymer solids that were structurally characterized via single-crystal X-ray diffraction. [Cd(cis-13cdc)(4-bpmp)]n (1, cis-13cdc = cis-1,3-cyclohexanedicarboxylate) shows a sawtooth (4,4) grid topology. [Cd2(trans-12cdc)2(4-bpmp)]n (2,

  硝酸镉，双（4-吡啶基甲基）哌嗪（4-bpmp）和各种环己基二羧酸酯配体的水热反应生成了三种新的配位聚合物固体，通过单晶X射线衍射对其结构进行了表征。[Cd（顺式-13cdc）（4-bpmp）] n（1，顺式-13cdc =顺式-1,3-环己烷二甲酸）显示锯齿状（4,4）网格拓扑。[Cd 2（反式-12cdc）2（4-bpmp）] n（2，反式-12cdc =反式-1,2-环己烷二羧酸酯）显示独特的4,5-连接层状（4 6）（4 6 6 4）拓扑，具有嵌入的[Cd 2（trans -12cdc）2 ]色带图案。[Cd（顺式-12chedc）（4-bpmp）]·0.25H 2 O} n（3，顺式-12chedc =顺式-1,2-环己-4-烯二羧酸酯）表示3D 3,5-连接的自-以前所未有的（4 2 6）（4 2 6 5 8 3）拓扑渗透网络。讨论了这三种新材料的热分解，发光和硝基芳族化合物的检测特性。
• Diverse interpenetration schemes and topologies in cobalt coordination polymers constructed from 2-carboxycinnamic acid and a long-spanning dipyridylpiperazine ligand
  作者：Alec D. Shrode、Robert L. LaDuca

  DOI：10.1016/j.molstruc.2018.06.067

  日期：2018.11

  interpenetrated 4-connected 6 6 dia network. Use of the dipyridylamide bis(4-pyridylformyl)piperazine (4-bpfp) produced a crystalline mixture of the major product 3D 6-connected 4 12 6 3 pcu network coordination polymer [Co(cca)(4-bpfp)]·2H 2 O} n ( 2 ) and the minor product 1D chain coordination polymer [Co(dibf) 2 (4-bpfp)(H 2 O) 2 ] n ( 3, dibf = 3-dihydro-3-oxo-1-isobenzofuranacetate). The in situ rearrangement

  摘要 硝酸钴、2-羧基肉桂酸 (H 2 cca) 和长跨度联吡啶型配体的水热反应产生了三种配位聚合物，这些聚合物通过单晶 X 射线衍射表征并表现出不同的结构拓扑和互穿方案。[Co(cca)(4-bpmp)(H 2 O) 2 ]·4H 2 O} n ( 1 , 4-bpmp = bis(4-pyridylmethyl)piperazine) 显示 2-fold 互穿 4-connected 6 6迪亚网络。使用二吡啶基酰胺双(4-吡啶基甲酰基)哌嗪 (4-bpfp) 产生了主要产物 3D 6-connected 4 12 6 3 pcu 网络配位聚合物 [Co(cca)(4-bpfp)]·2H 的结晶混合物2 O} n ( 2 ) 和次要产物一维链配位聚合物 [Co(dibf) 2 (4-bpfp)(H 2 O) 2 ] n ( 3, dibf = 3-dihydro-3-oxo-1-isobenzofuranacetate