1-巯基-2-(4-羟基苯基)乙烷 | 67382-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 1-巯基-2-(4-羟基苯基)乙烷
• 英文名称: 1-mercapto-2-(4-hydroxyphenyl)ethane
• 英文别名: 4-(2-mercaptoethyl)phenol；4-ethylmercaptophenol；4-(2-sulfanylethyl)phenol
• CAS: 67382-72-3
• 化学式: C₈H₁₀OS
• 分子量: 154.233
• InChiKey: RUUIFRGVMIQIBM-UHFFFAOYSA-N

物化性质

• 沸点：
  125 °C(Press: 1 Torr)
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  21.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险类别：
  9
• 危险性防范说明：
  P280,P301+P312+P330,P305+P351+P338+P310
• 危险品运输编号：
  3082
• 危险性描述：
  H302,H315,H318,H410
• 包装等级：
  III

反应信息

• 作为反应物：
  描述：

  1-巯基-2-(4-羟基苯基)乙烷 、 quinolin-4-yl((1S,2S,4S,5R)-5-vinyl-quinuclidin-2-yl)methanol 在 偶氮二异丁腈 作用下， 以 氯仿 为溶剂， 以94%的产率得到4-(2-(2-((4S,8R)-2-((S)-hydroxy(quinolin-4-yl)methyl)quinuclidin-8-yl)ethylthio)ethyl)phenol
  参考文献：
  名称：

  （+）辛可宁装饰的树状聚合物作为可回收的有机催化剂

  摘要：

  已经制备了在表面上装饰有（+）-辛可宁部分的第一代和第四代磷树枝状聚合物，以用作有机催化剂。第一代枝晶在几种β-二羰基化合物的α-胺化反应中显示出最高的活性和对映选择性。观察到积极的树突效果。证明了它在10个周期内的恢复和重用，而没有任何活动损失。已对反应范围进行了初步研究。

  DOI：

  10.1002/cctc.201500580
• 作为产物：
  描述：

  对羟基苯乙醇 在 吡啶 、 硫脲 作用下， 以 乙醇 为溶剂， 反应 19.5h， 生成 1-巯基-2-(4-羟基苯基)乙烷
  参考文献：
  名称：

  Snow, Arthur W.; Foos, Edward E., Synthesis, 2003, # 4, p. 509 - 512

  摘要：

  DOI：

文献信息

• [EN] DIAMIDE INHIBITORS OF CYTOCHROME P450<br/>[FR] DIAMIDES INHIBITEURS DU CYTOCHROME P450
  申请人：SEQUOIA PHARMACEUTICALS INC

  公开号：WO2009105776A1

  公开（公告）日：2009-08-27

  Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.

  提供了抑制细胞色素P450酶的方法，可用于改善疾病的治疗，防止细胞色素P450酶降解药物或其他分子。提供了可作为增强剂的药物组合物，可改善药物的药代动力学，增强生物利用度，并增强通过细胞色素P450酶在体内降解的药物的治疗效果。
• Aliphatic thioacetate deprotection using catalytic tetrabutylammonium cyanide
  作者：Brian T. Holmes、Arthur W. Snow

  DOI：10.1016/j.tet.2005.09.092

  日期：2005.12

  A series of thiol-functionalized organic compounds were selected to analyze the scope and efficiency of a new thioacetate deprotection method using catalytic tetrabutylammonium cyanide (TBACN) to effect the transformation of a thioacetate group to a free thiol in the presence of a protic solvent. Particularly attractive are the mild reaction and workup conditions, reduced byproduct formation typically seen using literature methods and yields of greater than 80% for the free aliphatic thiols. This method is effective on aliphatic thiols with trityl, benzyl, p-halo-benzyl, phenethyl, phenoxyethyl, and cyclohexylethyl structural moieties, but it is not effective with thiophenols. Published by Elsevier Ltd.
• Acid-catalyzed solvolysis of N-sulfonyl- and N-acyl-O-arylhydroxylamines. Phenoxenium ions
  作者：Yasuyuki Endo、Koichi Shudo、Toshihiko Okamoto

  DOI：10.1021/ja00387a040

  日期：1982.11
• Process for producing vinyl alcohol polymer
  申请人：Kuraray Co., Ltd.

  公开号：EP0757060B1

  公开（公告）日：1999-10-20
• PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PHOTOSENSITIVE DRY FILM, METHOD OF MANUFACTURING PATTERNED RESIST FILM, METHOD OF MANUFACTURING SUBSTRATE WITH TEMPLATE AND METHOD OF MANUFACTURING PLATED ARTICLE
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US20200292939A1

  公开（公告）日：2020-09-17

  A photosensitive resin composition; a photosensitive dry film which includes a photosensitive resin layer formed from the composition; a method of manufacturing the photosensitive dry film; a method of manufacturing a patterned resist film using the composition; a method of manufacturing a substrate with a template using the composition; and a method of manufacturing a plated article using the substrate with the template. In a photosensitive resin composition containing a resin which includes a (meth)acrylic polymer including a carboxy group, a specific amount of compound including a phenolic hydroxyl group and/or a mercapto group is contained together with a polyfunctional vinyl ether monomer.