(2-ethoxy-ethanesulfonyl)-ethene | 17700-26-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: (2-ethoxy-ethanesulfonyl)-ethene
• 英文别名: 1-Ethenylsulfonyl-2-ethoxyethane
• CAS: 17700-26-4
• 化学式: C₆H₁₂O₃S
• 分子量: 164.225
• InChiKey: FIORWHRNHCKGOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-ethoxy-ethanesulfonyl)-ethene 、 二正丙胺 生成 <2-Dipropylamino-ethyl>-<2-ethoxy-ethyl>-sulfon
  参考文献：
  名称：

  Prilezhaeva,E.N.; Shapiro,E.S., Doklady Chemistry, 1967, vol. 174, p. 579 - 582

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙烯基砜 、 乙醇 在 苄基三甲基氢氧化铵 作用下， 生成 (2-ethoxy-ethanesulfonyl)-ethene
  参考文献：
  名称：

  Prilezhaeva,E.N.; Shapiro,E.S., Doklady Chemistry, 1967, vol. 174, p. 579 - 582

  摘要：

  DOI：

文献信息

• Nucleophile-mediated oxa-Michael addition reactions of divinyl sulfone – a thiol-free option for step-growth polymerisations
  作者：Simone Strasser、Christian Slugovc

  DOI：10.1039/c5cy01527h

  日期：——

  Triphenylphosphine and 4-dimethylaminopyridine promote the oxa-Michael addition reaction of alcohols and divinyl sulfone. Under solvent-free conditions, the reaction is particularly fast and allows for the preparation of polymers.

  三苯基膦和4-二甲基氨基吡啶促进了醇与二乙烯基砜的氧杂-迈克尔加成反应。在无溶剂条件下，反应特别快，可以制备聚合物。
• BRYOSTATIN ANALOGUES AND METHODS OF MAKING AND USING THEREOF
  申请人：Keck Gary E.

  公开号：US20110269713A1

  公开（公告）日：2011-11-03

  Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.

  本文描述的是三环大环内酯。这些大环内酯对蛋白激酶C（PKC）具有很高的结合亲和力。本文描述的化合物可用于多种治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文描述的化合物还可以用于治疗记忆丧失。本文还描述了生产大环内酯的方法。这些方法允许在更少的步骤中以更高的置换度和特异性高产合成大环内酯。
• POLYMER CONJUGATES OF GLP-1
  申请人：Bossard Mary J.

  公开号：US20100210505A1

  公开（公告）日：2010-08-19

  Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached to a water-soluble polymer, wherein the GLP-I moiety possesses an N-methyl substituent. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-I moiety is glycosylated at a site separate from the polymer attachment site.

  GLP-I基团的共轭物可以共价地附加在一个或多个水溶性聚合物上。例如，GLP-I聚合物共轭物可以包括一个GLP-I基团可释放地附着在其N-末端到水溶性聚合物上。GLP-I聚合物共轭物可以包括一个GLP-I基团共价附着在水溶性聚合物上，其中GLP-I基团具有一个N-甲基取代基。GLP-I聚合物共轭物可以包括一个GLP-I基团共价附着在聚合物附着位点到水溶性聚合物上，其中GLP-I基团在与聚合物附着位点分离的位点被糖基化。
• POLYMER CONJUGATES OF KISS1 PEPTIDES
  申请人：Minamitani Elizabeth Louise

  公开号：US20110171160A1

  公开（公告）日：2011-07-14

  The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.

  本发明提供了通过共价连接水溶性寡聚体进行化学修饰的肽。本发明的结合物在通过多种给药途径进行给药时，表现出与未连接水溶性寡聚体的肽不同的特性。
• CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS
  申请人：McManus Samuel P.

  公开号：US20120100096A1

  公开（公告）日：2012-04-26

  The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.

  本发明涉及小干扰核酸（siNA）的结合物。本发明描述了适用于向患者施用的siNA组成物。还描述了传递这些组成物的方法。