2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid | 383661-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid
• 英文别名: (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-1-(3-acetoxy-2,2-dimethylpropyl)-2-oxo-4,1-benzoxazepin-3-acetic acid；(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid；(3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-acetic acid；2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetic acid
• CAS: 383661-55-0
• 化学式: C₂₆H₃₀ClNO₈
• 分子量: 519.979
• InChiKey: XDYXHEVDYHBTIF-FYYLOGMGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid 在 1-羟基-1H-苯并三唑铵盐 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 13.0h， 生成 3-[(3R,5S)-3-(2-amino-2-oxoethyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-2,3-dihydro-4,1-benzoxazepin-1(5H)-yl]-2,2-dimethylpropyl acetate
  参考文献：
  名称：

  EP1650201

  摘要：

  公开号：
• 作为产物：
  描述：

  (3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid 以90.0的产率得到2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid
  参考文献：
  名称：

  Highly Selective Novel Amidation Method

  摘要：

  本发明提供了一种工业生产方法，该方法具有短工艺流程，高产率，用廉价的缩合剂进行功能基选择性反应，不需要通过酯化来保护羧基，即将羧酸和三级羧酸卤化物反应得到羧酸酐，然后与具有羧基的脂环状二级胺反应。

  公开号：

  US20070238721A1

文献信息

• Benzoxazepinones and their use as squalene synthase inhibitors
  申请人：——

  公开号：US20030078251A1

  公开（公告）日：2003-04-24

  There is disclosed a compound represented by the formula [I]: 1 wherein R 1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, —X 1 —X 2 —Ar—X 3 —X 4 —COOH (wherein X 1 and X 4 are a bond or alkylene group, X 2 and X 3 are a bond, —O—, —S—, Ar is divalent aromatic group etc.), R 2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R 3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.

  披露了一种由公式[I]表示的化合物： 1 其中R 1 是可选地取代的1-羧乙基，可选地取代的烷基亚磺酰基，可选地取代的(羧基环烷基)-烷基，—X 1 —X 2 —Ar—X 3 —X 4 —COOH(其中X 1 和X 4 是键或亚烷基，X 2 和X 3 是键，—O—，—S—，Ar是二价芳香族等)，R 2 是可选地由酰氧基和/或羟基取代的烷基，R 3 是烷基，W是卤素原子等，或其盐。该化合物具有降低胆固醇活性和降低甘油三酯活性，用于预防或治疗高脂血症。
• [EN] HIGHLY SELECTIVE NOVEL AMIDATION METHOD<br/>[FR] PROCÉDÉ D'UNE NOUVELLE AMIDATION TRÈS SÉLECTIVE
  申请人：TAKEDA PHARMACEUTICAL

  公开号：WO2005121133A1

  公开（公告）日：2005-12-22

  The present invention provides an industrial production method with a short process having a high yield of an aliphatic cyclic carboxamide having carboxyl group, which comprises reacting functional group-selectively using an inexpensive condensing agent without protecting the carboxyl group by esterification, that is, reacting carboxylic acid anhydride obtained by reacting carboxylic acid and tertiary carboxylic acid halide with aliphatic cyclic secondary amine having carboxyl group.

  本发明提供了一种工业生产方法，该方法具有短流程、高产率，用于制备含有羧基的脂肪族环状酰胺，其特点在于使用廉价的缩合剂对功能团进行选择性反应，而不通过酯化保护羧基，即通过将由羧酸与叔羧酸卤化物反应得到的羧酸酐与含有羧基的脂肪族环状仲胺进行反应。
• Preventives/remedies for organ functional disorders and organ dysfunction
  申请人：——

  公开号：US20040204500A1

  公开（公告）日：2004-10-14

  The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

  本发明提供了一种用于预防或治疗器官功能障碍的药剂、用于预防或治疗器官功能障碍的药剂以及用于预防或治疗肥胖和其中的脱水症的药剂，每种药剂均包含具有增加泛醌或其盐或其前药的效果的化合物；以及一种增加泛醌的剂量，包括具有角鲨烷合成酶抑制作用或其盐或前药的化合物。
• Agent for preventing or treating organ functional disorders and organ dysfunction
  申请人：Sugiyama Yasuo

  公开号：US20060241096A1

  公开（公告）日：2006-10-26

  The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.

  本发明提供了一种预防或治疗器官功能障碍的药剂、一种预防或治疗器官功能失调的药剂，以及一种预防或治疗肥胖和其代谢障碍的药剂，每种药剂均包含具有增加泛醌或其盐或其前药的效果的化合物；以及一种增加泛醌的药剂，包括具有角鲨烷合酶抑制作用或其盐或其前药的化合物。
• Benzoxazepine Compound
  申请人：Marui Shogo

  公开号：US20080227770A1

  公开（公告）日：2008-09-18

  A compound represented by the formula [1]: wherein ring A and ring B each represent an optionally substituted benzene ring; ring C represents an optionally further substituted aromatic ring; R 1 represents a lower alkyl group optionally substituted with an optionally substituted hydroxyl group; X 1a represents a bond or optionally substituted lower alkylene; X 1b represents a bond or optionally substituted lower alkylene; x 2 represents a bond, —O— or —S—; X 3 represents a bond or an optionally substituted divalent hydrocarbon group; Y represents an optionally esterified or amidated carboxyl group, or a salt thereof. The compound of the formula [I] is safer and has more potent lipid lowering activity such as squalene synthase inhibitory activity (cholesterol lowering activity) and triglyceride lowering activity, and thus it is a compound useful as an agent for preventing or treating hyperlipemia.

  一种由公式[1]表示的化合物：其中环A和环B分别表示可选择性取代的苯环；环C表示可选择性进一步取代的芳香环；R1表示可选择性取代的较低的烷基，其中还可选择性地取代有一个或多个羟基基团；X1a表示一个键或可选择性取代的较低的烷基烯；X1b表示一个键或可选择性取代的较低的烷基烯；x2表示一个键，-O-或-S-；X3表示一个键或可选择性取代的双价碳氢基团；Y表示可选择性酯化或酰胺化的羧基，或其盐。公式[I]的化合物更安全，并具有更强的降脂活性，如角鲨烷合酶抑制活性（降低胆固醇活性）和三酰甘油降低活性，因此它是一种有用的化合物，可用作预防或治疗高脂血症的药物。